在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KCNE3 Antibody, HRP conjugated

  • 中文名稱:
    KCNE3兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào):
    CSB-PA22569B0Rb
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KCNE3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KCNE3
  • 別名:
    KCNE3 antibody; Potassium voltage-gated channel subfamily E member 3 antibody; MinK-related peptide 2 antibody; Minimum potassium ion channel-related peptide 2 antibody; Potassium channel subunit beta MiRP2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Potassium voltage-gated channel subfamily E member 3 protein (1-57AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.
  • 基因功能參考文獻(xiàn):
    1. Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4 has been reported. PMID: 27922120
    2. Structural, computational, biochemical, and electrophysiological studies lead to an atomically explicit integrative structural model of the KCNE3-KCNQ1 complex that explains how KCNE3 induces the constitutive activation of KCNQ1 channel activity, a crucial component in K(+) recycling. PMID: 27626070
    3. Reported here are previously undiscovered protein-coding regions in exon 1 of hKCNE3 and hKCNE4 that extend their encoded extracellular domains by 44 and 51 residues, which yields full-length proteins of 147 and 221 residues, respectively. PMID: 27162025
    4. Based on current evidence from published studies, neither of the two variants from KCNE was significantly associated with the risk of Meniere's disease--{REVIEW} PMID: 26890422
    5. Data show that voltage-gated potassium channel KCNE3 directly affects the S4 movement in potassium channel KCNQ1. PMID: 26668384
    6. KCNQ1/KCNE3 channels make only a small contribution to basolateral conductance in normal colonic crypts, with increased channel activity in UC appearing insufficient to prevent colonic cell depolarization in this disease. PMID: 26718405
    7. KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation PMID: 26410412
    8. A KCNE3 T4A mutation was identified in a Japanese patient presenting Brugada-pattern ECG and neurally mediated syncope. PMID: 22987075
    9. Allele frequencies are studied for 11 known variants of KCNE3 gene, of which two (F66F and R83H) are polymorphic but are not associated with chronic tinnitus. PMID: 21899751
    10. The results of this study indicated that Kv7.5 contributes to the spatial regulation. PMID: 22190306
    11. 2 of the 8 MiRP2 extracellular domain acidic residues (D54 and D55) are important for KCNQ1-MiRP2 constitutive activation. PMID: 20040519
    12. data show that SNPs in KCNE1 and KCNE3 are not associated with Meniere disease in Caucasians PMID: 20034061
    13. The KCNE3 protein within the micellesis in monomeric form and acquires mainly alpha-helical conformation. PMID: 19961415
    14. Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. PMID: 11956246
    15. The authors found MiRP2-R83H in 3 of 321 control subjects and in 5 unaffected related individuals. Provocation of an unaffected carrier with glucose or KCl did not induce weakness. PMID: 15037716
    16. interaction of MiRP2-72 with KCNQ1-338; and MinK-59,58 with KCNQ1-339, 340 PMID: 16308347
    17. The result indicates that 112G/A SNP in the KCNE1 gene and 198T/C SNP in the KCNE3 gene could determine an increased susceptibility to develop MD. PMID: 16374062
    18. The characterization of a missense mutation in MiRP2 that affects its phosphorylation and consequent interactions with Kv3.4 is reported. PMID: 16449802
    19. KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2 PMID: 16782062
    20. Up-regulation and incrased activity of KV3.4 channels and their accessory subunit Mirp2 induced by amyloid peptide are involved in apoptotic neuronal death. PMID: 17495071
    21. Abnormalities in the KCNE3 gene is a potential genetic risk factor for initiation and/or maintenance of atrial fibrillation. PMID: 18209471
    22. KCNE3 plays a functional role in the modulation of I(to) in the human heart and suggest that mutations in KCNE3 can underlie the development of BrS. PMID: 19122847

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein. Cytoplasm. Perikaryon. Cell projection, dendrite. Membrane raft.
  • 蛋白家族:
    Potassium channel KCNE family
  • 組織特異性:
    Expressed in hippocampal neurons (at protein level). Widely expressed with highest levels in kidney and moderate levels in small intestine.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 6243

    OMIM: 604433

    KEGG: hsa:10008

    STRING: 9606.ENSP00000310557

    UniGene: Hs.523899



主站蜘蛛池模板: a片免费视频在线观看| 四虎影库久免费视频| 久久国产成人精品av| 亚洲欧美另类久久久精品| 四虎影视国产精品久久| 天天躁夜夜躁狠狠躁2021| 在线看免费无码av天堂的| 亚洲色成人中文字幕网站| 无码任你躁久久久久久老妇| 奇米综合四色77777久久| 亚洲五月色丁香婷婷婷| 22222se男人的天堂| 国产成人亚洲精品狼色在线| 五月丁香啪啪激情综合色九色| 午夜影视免费x看| 夫妇交换性三中文字幕| 国产乱了真实在线观看| 少妇扒开双腿让我看个够| 97在线观看永久免费视频| 日本乱人伦在线观看| 欧美xxxx做受欧美1314 | 欧美成人精品a∨在线观看| 制服丝袜有码中文字幕在线| 天堂а√在线地址8| 无码少妇精品一区二区免费| 极品少妇被黑人白浆直流| 国产精品久人妻精品老妇| 国产精品99精品久久免费| 午夜片神马影院福利| 国产亚洲综合欧美视频| 久久久久国色av免费观看性色| 亚洲综合无码久久精品综合| 亚洲一区二区三区在线观看网站| 777米奇色狠狠俺去啦| 久久国产一区二区三区| 久久96国产精品久久久| 内射视频←www夜| 亚洲人成网7777777国产| 亚洲欧美日韩国产手机在线| 国产 校园 另类 小说区| 久久久久久久久久久综合日本 |