在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KCNE3 Antibody, Biotin conjugated

  • 中文名稱:
    KCNE3兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA22569D0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KCNE3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KCNE3
  • 別名:
    KCNE3 antibody; Potassium voltage-gated channel subfamily E member 3 antibody; MinK-related peptide 2 antibody; Minimum potassium ion channel-related peptide 2 antibody; Potassium channel subunit beta MiRP2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Potassium voltage-gated channel subfamily E member 3 protein (1-57AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.
  • 基因功能參考文獻:
    1. Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4 has been reported. PMID: 27922120
    2. Structural, computational, biochemical, and electrophysiological studies lead to an atomically explicit integrative structural model of the KCNE3-KCNQ1 complex that explains how KCNE3 induces the constitutive activation of KCNQ1 channel activity, a crucial component in K(+) recycling. PMID: 27626070
    3. Reported here are previously undiscovered protein-coding regions in exon 1 of hKCNE3 and hKCNE4 that extend their encoded extracellular domains by 44 and 51 residues, which yields full-length proteins of 147 and 221 residues, respectively. PMID: 27162025
    4. Based on current evidence from published studies, neither of the two variants from KCNE was significantly associated with the risk of Meniere's disease--{REVIEW} PMID: 26890422
    5. Data show that voltage-gated potassium channel KCNE3 directly affects the S4 movement in potassium channel KCNQ1. PMID: 26668384
    6. KCNQ1/KCNE3 channels make only a small contribution to basolateral conductance in normal colonic crypts, with increased channel activity in UC appearing insufficient to prevent colonic cell depolarization in this disease. PMID: 26718405
    7. KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation PMID: 26410412
    8. A KCNE3 T4A mutation was identified in a Japanese patient presenting Brugada-pattern ECG and neurally mediated syncope. PMID: 22987075
    9. Allele frequencies are studied for 11 known variants of KCNE3 gene, of which two (F66F and R83H) are polymorphic but are not associated with chronic tinnitus. PMID: 21899751
    10. The results of this study indicated that Kv7.5 contributes to the spatial regulation. PMID: 22190306
    11. 2 of the 8 MiRP2 extracellular domain acidic residues (D54 and D55) are important for KCNQ1-MiRP2 constitutive activation. PMID: 20040519
    12. data show that SNPs in KCNE1 and KCNE3 are not associated with Meniere disease in Caucasians PMID: 20034061
    13. The KCNE3 protein within the micellesis in monomeric form and acquires mainly alpha-helical conformation. PMID: 19961415
    14. Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. PMID: 11956246
    15. The authors found MiRP2-R83H in 3 of 321 control subjects and in 5 unaffected related individuals. Provocation of an unaffected carrier with glucose or KCl did not induce weakness. PMID: 15037716
    16. interaction of MiRP2-72 with KCNQ1-338; and MinK-59,58 with KCNQ1-339, 340 PMID: 16308347
    17. The result indicates that 112G/A SNP in the KCNE1 gene and 198T/C SNP in the KCNE3 gene could determine an increased susceptibility to develop MD. PMID: 16374062
    18. The characterization of a missense mutation in MiRP2 that affects its phosphorylation and consequent interactions with Kv3.4 is reported. PMID: 16449802
    19. KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2 PMID: 16782062
    20. Up-regulation and incrased activity of KV3.4 channels and their accessory subunit Mirp2 induced by amyloid peptide are involved in apoptotic neuronal death. PMID: 17495071
    21. Abnormalities in the KCNE3 gene is a potential genetic risk factor for initiation and/or maintenance of atrial fibrillation. PMID: 18209471
    22. KCNE3 plays a functional role in the modulation of I(to) in the human heart and suggest that mutations in KCNE3 can underlie the development of BrS. PMID: 19122847

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cytoplasm. Perikaryon. Cell projection, dendrite. Membrane raft.
  • 蛋白家族:
    Potassium channel KCNE family
  • 組織特異性:
    Expressed in hippocampal neurons (at protein level). Widely expressed with highest levels in kidney and moderate levels in small intestine.
  • 數據庫鏈接:

    HGNC: 6243

    OMIM: 604433

    KEGG: hsa:10008

    STRING: 9606.ENSP00000310557

    UniGene: Hs.523899



主站蜘蛛池模板: 少妇人妻av无码专区| 国产一卡2卡3卡四卡精品app| 中文无码日韩欧免费视频| 国产精品视频永久免费播放| 国产精品乱码一区二区三 | 中国猛少妇色xxxxx| 久久久久久久久无码精品亚洲日韩 | 在线天堂最新版资源| 国产suv精品一区二区69| 欧美亚洲国产成人一区二区三区 | 国产女人高潮抽搐叫床视频| 日韩亚洲国产高清免费视频| 久久精品国产精品亚洲艾草网| 日本不卡一区二区三区在线| 日韩精品人涩人| 熟妇的奶头又大又长奶水视频| 亚洲人成亚洲人成在线观看| 精品久久久久国产免费| 337p日本大胆欧久久| 日韩中文无码有码免费视频| 久久99热人妻偷产国产| 中文字幕乱码中文乱码777| 亚洲综合av色婷婷| 国内精品自线在拍2020不卡 | 亚洲国产精品无码久久98| 亚洲无线观看国产精品| 色伦专区97中文字幕| 天堂а在线中文在线新版| 无码专区男人本色| 亚洲偷自拍国综合色帝国| 久久久久久亚洲精品a片成人| 亚洲最大成人网站| 久久综合色鬼综合色| 国产麻豆精品福利在线| 一区一区三区产品乱码| 中文字幕在线亚洲精品| 欧洲熟妇色xxxxx视频| 国产成人三级在线视频网站观看| 日本丰满熟妇videos| 欧美乱大交av片久久123| 亚洲精品无码少妇30p|