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  4. IYD Antibody, Biotin conjugated

IYD Antibody, Biotin conjugated

  • 中文名稱：
    IYD兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA754272LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) IYD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    IYD antibody; C6orf71 antibody; DEHAL1 antibody; Iodotyrosine deiodinase 1 antibody; IYD-1 antibody; EC 1.21.1.1 antibody; Iodotyrosine dehalogenase 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Iodotyrosine deiodinase 1 protein (24-147AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.
  • 基因功能參考文獻：
    1. The rate-limiting processes that contribute to the ability of flavin to promote reductive dehalogenation in human IYD. PMID: 26151430
    2. A switch between one- and two-electron chemistry of iodotyrosine deiodinase is controlled by substrate. PMID: 25395621
    3. Iodotyrosine deiodinase defect identified via genome-wide approach. PMID: 22535972
    4. high activity of human saliva peroxidase with iodide as a substrate may play a crucial role in the bioavailability and metabolism of biologically active iodide. PMID: 21870604
    5. Mutations in DEHAL1 leads to hypothyroidism, goiter and mental retardation (Review) PMID: 20298747
    6. molecular cloning and investigation of the localization and activity of DEHAL1 PMID: 15289438
    7. the cytoplasmic tail of DEHAL1 could play a role in the stability of the protein PMID: 16910871
    8. Diffuse cytoplasmatic localisation or downregulation of DEHAL1 expression in thyroid cancers suggests alteration or loss of DEHAL1 function during thyroid cell dedifferentiation. PMID: 17322488
    9. homozygous mutations in DEHAL1 appear to cause human iodotyrosine deiodinase deficiency, leading to hereditary hypothyroidism and goiter PMID: 18434651
    10. This study describes a functional mutation within IYD, demonstrating the molecular basis of the iodine wasting form of congenital hypothyroidism PMID: 18765512

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  • 相關疾病：
    Thyroid dyshormonogenesis 4 (TDH4)
  • 亞細胞定位：
    Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.
  • 蛋白家族：
    Nitroreductase family
  • 組織特異性：
    Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea.
  • 數據庫鏈接：

    HGNC: 21071

    OMIM: 274800

    KEGG: hsa:389434

    STRING: 9606.ENSP00000229447

    UniGene: Hs.310225



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