在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ITGB5 Antibody

  • 中文名稱:
    ITGB5兔多克隆抗體
  • 貨號:
    CSB-PA546880
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA546880(ITGB5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA546880(ITGB5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ITGB5; Integrin beta-5
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human ITGB5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.
  • 基因功能參考文獻(xiàn):
    1. High ITGB5 expression is associated with cervical cancer. PMID: 26758421
    2. FAK activity regulates beta5 integrin expression and anchorage-independent cell growth in ovarian carcinoma. PMID: 24899686
    3. FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1 PMID: 25448675
    4. Immunohistochemical analysis for alphavbeta3, alphavbeta5 and alphavbeta6 integrin subunits was performed and correlated with Ki67 and hypoxia-inducible factor (HIF)-1alpha indexes PMID: 25150423
    5. Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration PMID: 24997346
    6. we demonstrated via antibody blocking experiments that aV b5 and a6 significantly promoted hESC attachment in 2%oxygen only, whereas blockage of CD44 inhibited cell attachment in 21% O2 alone PMID: 24455718
    7. Brain metastases ITGB5 expression exhibits considerable heterogeneity according to tumor origin. PMID: 24294359
    8. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. PMID: 24036928
    9. molecular model of integrin b5 structure was prepared and stereo chemical model quality was checked. Integrin b5 active sites were identified based on insilico analysis tools. PMID: 23962022
    10. BDNF enhances the migration of chondrosarcoma by increasing beta5 integrin expression through a signal transduction pathway that involves the TrkB receptor, PI3K, Akt, and NF-kappaB. PMID: 23874483
    11. The top primary GWAS association of Airway hyperresponsiveness was in rs848788(P-value 7.2E-07) located within the ITGB5 genes. PMID: 23984888
    12. Depletion of integrin beta5 in triple-negative breast carcinoma cells markedly reduced tumor take, growth and tumor angiogenesis, whereas reexpression of integrin beta5 rescued this phenotype; findings show a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells PMID: 22824793
    13. High beta5-integrin protein expression is associated with aggressive behavior in gastric cancer. PMID: 22561002
    14. Letter: loss of integrin beta5 in polyomavirus positive Merkel cell carcinoma may influence cell adhesion/migration. PMID: 22503669
    15. Cysteine-rich protein Cyr61 activates interleukin (IL)-6 production via the alphavbeta5/Akt/NF-kappaB signaling pathway in rheumatoid arthritis. PMID: 22547695
    16. The beta5-integrin adhesions contribute to the TGFbeta-induced EMT and the tumorigenic potential of carcinoma cells. PMID: 20404485
    17. p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration PMID: 20507994
    18. Src kinase-mediated activation of STAT3 and subsequent angiogenic gene expression mediate the effects of integrin alpha v beta 5 and may be exploited to enhance the paracrine activities of circulating angiogenic cells. PMID: 20431064
    19. Overexpression of the beta5 integrin in hematopoietic cells was associated with the inhibition of cell proliferation and apoptosis. PMID: 11877043
    20. different beta5 integrins: repeated-FNK (FNKFNK764-769) and single-FNK (FNK764-766) amino acid sequences in the cytoplasmic domain. PMID: 15979906
    21. Our studies suggest that the phagocytic function of beta5 integrin is regulated by an unconventional NPxY-talin-independent activation signal and argue for the existence of molecular switches in the beta5 cytoplasmic tail for adhesion and phagocytosis. PMID: 17963729

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Integrin beta chain family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6160

    OMIM: 147561

    KEGG: hsa:3693

    STRING: 9606.ENSP00000296181

    UniGene: Hs.13155



主站蜘蛛池模板: 美女张开腿黄网站免费| 人妻精品动漫h无码中字| a亚洲va欧美va国产综合| 一区二区三区国产亚洲网站| 国产激情无码视频在线播放| 人妻熟女一区二区aⅴ水野朝阳| 嫩草伊人久久精品少妇av| 国产午夜视频在线观看| 亚洲国产成人久久综合碰| 亚洲欧美日韩综合一区在线| 曰批视频免费30分钟成人| 麻豆精品一区二区综合av| 日日摸天天碰中文字幕你懂的| 在线天堂资源www在线污| 果冻传媒18禁免费视频| 色婷婷av99xx| 天天躁日日躁狠狠躁2018| 亚洲国产精品成人精品无码区| 国产午夜精品无码一区二区| 236宅宅理论片免费| 中文字幕三级人妻无码视频| 国产成人综合一区人人| 精品久久久无码中文字幕| 中日韩高清无专码区2021| 免费观看在线a毛片| 人妻av乱片av出轨av| 欧美激情肉欲高潮视频| 亚洲狠狠成人网| 亚洲精品av网站在线观看| 国产偷窥熟女精品视频大全| 久久人人爽人人爽人人av东京热| 日韩人妻无码免费视频一二区 | 国产欧美日本亚洲精品一5区| 久久久日韩精品一区二区| 色天天天综合色天天| 日本老熟妇乱子伦视频| 人妻互换一二三区激情视频 | 亚洲妇女行蜜桃av网网站| 欧美精品v欧洲精品| 成人综合婷婷国产精品久久蜜臀 | 1000部又爽又黄无遮挡的视频|