在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ITGB5 Antibody, HRP conjugated

  • 中文名稱:
    ITGB5兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA011889LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ITGB5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ITGB5; Integrin beta-5
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Integrin beta-5 protein (431-637AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.
  • 基因功能參考文獻:
    1. High ITGB5 expression is associated with cervical cancer. PMID: 26758421
    2. FAK activity regulates beta5 integrin expression and anchorage-independent cell growth in ovarian carcinoma. PMID: 24899686
    3. FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1 PMID: 25448675
    4. Immunohistochemical analysis for alphavbeta3, alphavbeta5 and alphavbeta6 integrin subunits was performed and correlated with Ki67 and hypoxia-inducible factor (HIF)-1alpha indexes PMID: 25150423
    5. Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration PMID: 24997346
    6. we demonstrated via antibody blocking experiments that aV b5 and a6 significantly promoted hESC attachment in 2%oxygen only, whereas blockage of CD44 inhibited cell attachment in 21% O2 alone PMID: 24455718
    7. Brain metastases ITGB5 expression exhibits considerable heterogeneity according to tumor origin. PMID: 24294359
    8. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. PMID: 24036928
    9. molecular model of integrin b5 structure was prepared and stereo chemical model quality was checked. Integrin b5 active sites were identified based on insilico analysis tools. PMID: 23962022
    10. BDNF enhances the migration of chondrosarcoma by increasing beta5 integrin expression through a signal transduction pathway that involves the TrkB receptor, PI3K, Akt, and NF-kappaB. PMID: 23874483
    11. The top primary GWAS association of Airway hyperresponsiveness was in rs848788(P-value 7.2E-07) located within the ITGB5 genes. PMID: 23984888
    12. Depletion of integrin beta5 in triple-negative breast carcinoma cells markedly reduced tumor take, growth and tumor angiogenesis, whereas reexpression of integrin beta5 rescued this phenotype; findings show a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells PMID: 22824793
    13. High beta5-integrin protein expression is associated with aggressive behavior in gastric cancer. PMID: 22561002
    14. Letter: loss of integrin beta5 in polyomavirus positive Merkel cell carcinoma may influence cell adhesion/migration. PMID: 22503669
    15. Cysteine-rich protein Cyr61 activates interleukin (IL)-6 production via the alphavbeta5/Akt/NF-kappaB signaling pathway in rheumatoid arthritis. PMID: 22547695
    16. The beta5-integrin adhesions contribute to the TGFbeta-induced EMT and the tumorigenic potential of carcinoma cells. PMID: 20404485
    17. p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration PMID: 20507994
    18. Src kinase-mediated activation of STAT3 and subsequent angiogenic gene expression mediate the effects of integrin alpha v beta 5 and may be exploited to enhance the paracrine activities of circulating angiogenic cells. PMID: 20431064
    19. Overexpression of the beta5 integrin in hematopoietic cells was associated with the inhibition of cell proliferation and apoptosis. PMID: 11877043
    20. different beta5 integrins: repeated-FNK (FNKFNK764-769) and single-FNK (FNK764-766) amino acid sequences in the cytoplasmic domain. PMID: 15979906
    21. Our studies suggest that the phagocytic function of beta5 integrin is regulated by an unconventional NPxY-talin-independent activation signal and argue for the existence of molecular switches in the beta5 cytoplasmic tail for adhesion and phagocytosis. PMID: 17963729

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Integrin beta chain family
  • 數據庫鏈接:

    HGNC: 6160

    OMIM: 147561

    KEGG: hsa:3693

    STRING: 9606.ENSP00000296181

    UniGene: Hs.13155



主站蜘蛛池模板: 一区二区三区在线 | 欧| 亚洲の无码国产の无码步美| 亚洲精品无amm毛片| 国产亚洲人成a在线v网站| 国产精品久人妻精品| 美国特级a毛片免费网站| 人妻体验按摩到忍不住哀求继续| 国产成人精品亚洲日本在线| 国产高清视频一区三区| 97人妻无码专区| 久久久久久夜精品精品免费啦| 国产在线精品一区二区三区不卡| 国产午夜福利100集发布| 一本大道久久香蕉成人网| 无码大潮喷水在线观看| 国产99视频精品免费视看6| 欧美不卡一区二区三区| 97人妻天天爽夜夜爽二区| 中文字幕久精品免费视频| 伊人精品成人久久综合97| 国产乱子伦农村xxxx| 精品无码久久久久久国产| 99精品产国品一二三产区| 国产精品女丝袜白丝袜| 人妻 日韩 欧美 综合 制服| 狠狠色噜噜狠狠狠狠888奇禾| 亚洲精品av一区在线观看| 拍摄av现场失控高潮数次| 亚洲精品97久久中文字幕无码| 欧美日韩无套内射另类| 无码人妻一区、二区、三区免费视频| 5858s亚洲色大成网站www| 人妻另类 专区 欧美 制服| 日本高清va在线播放| 伊人久久精品无码二区麻豆 | 日本xxxx片免费观看| 怡红院a∨人人爰人人爽| 国内精品久久久久久久久齐齐| 久久超碰极品视觉盛宴| 国产精品盗摄!偷窥盗摄| 亚洲精品自产拍在线观看|