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IPPK Antibody

  • 中文名稱:
    IPPK兔多克隆抗體
  • 貨號:
    CSB-PA050062
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    3 antibody; 4 antibody; 5 antibody; 6)P5 2-kinase antibody; 6-pentakisphosphate 2-kinase antibody; bA476B13.1 (novel protein) antibody; bA476B13.1 antibody; C9orf12 antibody; inositol 1,3,4,5,6 pentakisphosphate 2 kinase antibody; Inositol pentakisphosphate 2 kinase antibody; Inositol-1 antibody; Inositol-pentakisphosphate 2-kinase antibody; Ins antibody; Ins(1 antibody; Ins(1,3,4,5,6)P5 2 kinase antibody; InsP5 2 kinase antibody; InsP5 2-kinase antibody; INSP5K2 antibody; IP5K antibody; IPK1 antibody; IPK1 homolog antibody; IPPK antibody; IPPK_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human InsP5 2-kinase.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.
  • 基因功能參考文獻:
    1. These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism. PMID: 29746542
    2. IP6 synthase, Ins(1,3,4,5,6)P5 2-kinase (IPPK/IP5K) binds to cullins. Depleting IP5K increases the percentage of neddylated, active Cul1 and Cul4A, and decreases levels of the Cul1/4A substrates p27 and p21. PMID: 26976604
    3. IPK1 substrate selection is linked to the ability of each potential substrate to stabilize IPK1. PMID: 24165122
    4. identified a genomic DNA sequence on chromosome 9 that encodes inositol 1,3,4,5,6-pentakisphosphate 2-kinase; characterization of the enzyme PMID: 12084730
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    IPK1 type 2 family
  • 組織特異性:
    Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
  • 數據庫鏈接:

    HGNC: 14645

    KEGG: hsa:64768

    STRING: 9606.ENSP00000287996

    UniGene: Hs.459896



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