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  4. IPPK Antibody

IPPK Antibody

  • 中文名稱：
    IPPK兔多克隆抗體
  • 貨號：
    CSB-PA067183
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from RAW cells,K562 cells, LOVO cells and 3T3 cells, using IPPK antiobdy.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using IPPK antibody.
    • Immunofluorescence analysis of HepG2 cells, using IPPK antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) IPPK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human IPPK.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.
  • 基因功能參考文獻：
    1. These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism. PMID: 29746542
    2. IP6 synthase, Ins(1,3,4,5,6)P5 2-kinase (IPPK/IP5K) binds to cullins. Depleting IP5K increases the percentage of neddylated, active Cul1 and Cul4A, and decreases levels of the Cul1/4A substrates p27 and p21. PMID: 26976604
    3. IPK1 substrate selection is linked to the ability of each potential substrate to stabilize IPK1. PMID: 24165122
    4. identified a genomic DNA sequence on chromosome 9 that encodes inositol 1,3,4,5,6-pentakisphosphate 2-kinase; characterization of the enzyme PMID: 12084730
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    IPK1 type 2 family
  • 組織特異性：
    Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
  • 數據庫鏈接：

    HGNC: 14645

    KEGG: hsa:64768

    STRING: 9606.ENSP00000287996

    UniGene: Hs.459896



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