在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. IPO11 Antibody

IPO11 Antibody

  • 中文名稱：
    IPO11兔多克隆抗體
  • 貨號：
    CSB-PA011775GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    IPO11
  • 別名：
    Imp11 antibody; Importin 11 antibody; Importin-11 antibody; IPO11 antibody; IPO11_HUMAN antibody; Ran binding protein 11 antibody; Ran-binding protein 11 antibody; RanBP11 antibody; SLRN antibody; Synleurin antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human IPO11
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBE2E3, and of RPL12.
  • 基因功能參考文獻：
    1. High IPO11 expression is associated with migration, invasion, and progression of bladder cancer. PMID: 29602637
    2. IPO11 copy number amplification and importin-11 overexpression are promising biomarkers for predicting the progression and poor prognosis of patients with NMIBC. PMID: 27689332
    3. IPO11 provides protection in another way, the researchers found. The transport receptor also shuttles UBE2E1, an enzyme necessary for PTEN ubiquitination, into the nucleus. Thanks to IPO11, normal cells keep all of their UBE2E1 in the nucleus, allowing PTEN to continue functioning in the cytoplasm. In cells lacking IPO11, UBE2E1 remains in the cytoplasm and promotes the destruction of PTEN. PMID: 28258103
    4. IPO11-HTR1A is a significant risk gene region for attention deficit hyperactivity disorder in Caucasians. PMID: 26079129
    5. Data indicate that ubiquitin-conjugating enzyme UBE2E3 and importin 11 (Imp-11)promote the nuclear accumulation and activity of transcription factor NF-E2 (Nrf2) by restricting the transcription factor from partitioning to the mitochondria PMID: 25378586

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Importin beta family
  • 數據庫鏈接：

    HGNC: 20628

    OMIM: 610889

    KEGG: hsa:51194

    STRING: 9606.ENSP00000386992

    UniGene: Hs.482269



主站蜘蛛池模板： 综合久久—本道中文字幕| 国产午夜精品理论片| 日本丰满熟妇videossex| 久久精品成人免费观看97| 欧美xxxx做受视频| 国产精品久线在线观看| 熟妇人妻无码xxx视频| 亚洲人禽杂交av片久久| 亚洲毛片多多影院| 欧美高清在线精品一区| 亚洲中文字幕乱码电影| 国产欧美日韩亚洲精品专区| 亚洲色欲色欲www在线观看| 特级毛片爽www免费版| 国产精品国产三级国av麻豆| 日本乱人伦aⅴ精品| 粉嫩av国产一区二区三区| 98国产精品综合一区二区三区| 久久精品人人爽人人爽| 奇米影视7777狠狠狠狠影视| 欧美牲交a欧牲交aⅴ久久| 香蕉伊蕉伊中文视频在线 | 亚洲卡一卡二卡三新区乱码| 亚洲а∨精品天堂在线| 另类内射国产在线| 国产美女爽到尿喷出来视频| 香蕉在线 亚洲 欧美 专区| 精品国产av 无码一区二区三区| 无码毛片视频一区二区本码| 亚洲国产av高清无码| 伊在人天堂亚洲香蕉精品区| 亚洲精品专区成人网站| 精品欧美一区二区三区久久久| 久热这里只有精品视频6| 120秒试看无码体验区| 精品人妻va出轨中文字幕| 亚洲熟熟妇xxxx| 欧美xxxx做受欧美69| 成人精品v视频在线| 粗了大了 整进去好爽视频| 国产区又黄又硬高潮的视频|