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INPP5B Antibody, Biotin conjugated

  • 中文名稱:
    INPP5B兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA011734LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) INPP5B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    4 antibody; 5-trisphosphate 5-phosphatase antibody; 5PTase antibody; 75 kDa inositol polyphosphate 5 phosphatase antibody; 75 kDa inositol polyphosphate-5-phosphatase antibody; 75kDa antibody; EC 3.1.3.36 antibody; I5P2_HUMAN antibody; Inositol polyphosphate 5-phosphatase II antibody; Inositol polyphosphate-5-phosphatase B antibody; Inositol polyphosphate-5-phosphatase; 75kDa antibody; INPP5B antibody; Inpp5b protein antibody; INPP5P antibody; MGC65156 antibody; MGC71303 antibody; OTTHUMP00000004726 antibody; OTTHUMP00000004727 antibody; OTTHUMP00000004728 antibody; Phosphoinositide 5 phosphatase antibody; Phosphoinositide 5-phosphatase antibody; Type II inositol 1,4,5 trisphosphate 5 phosphatase antibody; Type II inositol-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Type II inositol 1,4,5-trisphosphate 5-phosphatase protein (78-178AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
  • 基因功能參考文獻:
    1. OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells PMID: 25305077
    2. The crystal structures of human INPP5B in complex with phosphoinositide substrate analogs revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer. PMID: 24704254
    3. study found mouse Inpp5b and human INPP5B differ in their transcription, splicing and amino acid sequence; observations form foundation for analyzing the functional basis for the difference in how Inpp5b and INPP5B compensate for loss of Ocrl function PMID: 20872266
    4. The homologous phosphatase Inpp5b was unable to complement the Ocrl1-dependent cell migration defect. PMID: 19700499
    5. INPP5B is also localised to the early secretory pathway including the Golgi apparatus and ER-to-Golgi intermediate compartment (ERGIC). PMID: 17956944
    6. The NH2-terminal region of OCRL, but not of INPP5B, binds clathrin heavy chain. PMID: 19536138

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  • 亞細胞定位:
    Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane. Golgi apparatus.
  • 蛋白家族:
    Inositol 1,4,5-trisphosphate 5-phosphatase type II family
  • 組織特異性:
    Platelets.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6077

    OMIM: 147264

    KEGG: hsa:3633

    STRING: 9606.ENSP00000362115

    UniGene: Hs.449942



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