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  4. ING3 Antibody

ING3 Antibody

  • 中文名稱：
    ING3兔多克隆抗體
  • 貨號：
    CSB-PA011714GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ING3
  • 別名：
    ING3 antibody; HSPC301 antibody; Inhibitor of growth protein 3 antibody; p47ING3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ING3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
  • 基因功能參考文獻：
    1. results reveal the molecular mechanism of H3K4me3 selection by the ING3PHD and suggest that this interaction is important for mediating ING3 tumor suppressive activities. PMID: 27281824
    2. High ING3 expression is associated with prostate cancer. PMID: 26803516
    3. ING3 levels may serve as a surrogate for growth rate, and suggest possible roles for ING3 in growth and self renewal and related diseases such as cancer. PMID: 25819753
    4. Downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. PMID: 24927342
    5. that ING3 may be an important marker for human hepatocellular carcinoma progression and prognosis, as well as a potential therapeutic target. PMID: 22550337
    6. Data show that ING3 is degraded by the ubiquitin-proteasome pathway through the SCF(Skp2) complex. PMID: 19935701
    7. we have isolated a novel ING family gene, p47ING3, which modulates p53-mediated transcription, cell cycle control, and apoptosis. The p47ING3 gene is located at chromosome 7q31.3 and consists of 12 exons that encode 418 amino acids PMID: 12545155
    8. ING3 may be an important marker for human melanoma progression and prognosis as well as a potential therapeutic target. PMID: 17634537
    9. ING3 would function as a potential tumor suppressor molecule and that low levels of ING3 may indicate an aggressive nature of head and neck cancer. PMID: 18081876
    10. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. PMID: 12080476

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  • 相關疾病：
    Squamous cell carcinoma of the head and neck (HNSCC)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    ING family
  • 組織特異性：
    Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.
  • 數據庫鏈接：

    HGNC: 14587

    OMIM: 275355

    KEGG: hsa:54556

    STRING: 9606.ENSP00000320566

    UniGene: Hs.489811



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