在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IGFBP6 Antibody

  • 中文名稱:
    IGFBP6兔多克隆抗體
  • 貨號:
    CSB-PA011100LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA011100LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA011100LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) IGFBP6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    IGFBP6
  • 別名:
    IBP 6 antibody; IBP-6 antibody; IBP6 antibody; IBP6_HUMAN antibody; IGF binding protein 6 antibody; IGF-binding protein 6 antibody; IGFBP 6 antibody; IGFBP-6 antibody; IGFBP6 antibody; Insulin like growth factor binding protein 6 antibody; Insulin-like growth factor-binding protein 6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Insulin-like growth factor-binding protein 6 protein (32-161AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,IGFBP6 Antibody (CSB-PA011100LA01HU),的標記方式是Non-conjugated。對于IGFBP6 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA011100LB01HU IGFBP6 Antibody, HRP conjugated ELISA
    FITC CSB-PA011100LC01HU IGFBP6 Antibody, FITC conjugated
    Biotin CSB-PA011100LD01HU IGFBP6 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.
  • 基因功能參考文獻:
    1. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug. PMID: 29577195
    2. IGFBP-6 could inhibit invasion and migration of colorectal carcinoma cells PMID: 29439316
    3. IGFBP6 might be an important regulator and prognostic factor for glioma. PMID: 27650075
    4. Results suggest that insulin like growth factor binding protein 6 (IGFBP6) may be an independent prognostic biomarker for nasopharyngeal carcinoma (NPC). PMID: 27623076
    5. We identified a novel SNP variant, Chr12:g.53494591T>C. c.T430C (p.S144P) in the insulin-like growth factor binding protein-6 (IGFBP6) gene. This variant was shared by all affected family members, but not by unaffected members. The c.T430C (p.S144P) variant of IGFBP6 was identified as the likely causal variant associated with increased risk of familial disc degeneration in the studied pedigree. PMID: 28829625
    6. We found that IGFBP6 and SATB2 were significantly down-regulated in HIV-infected CEM*174 cells and 3 different cohorts of HIV/AIDS patients while their promoters were predominantly hyper-methylated compared with normal controls. PMID: 26039376
    7. IGFBP6 attenuation in ACTH-secreting pituitary adenomas is associated with tumor growth, through activation of PI3K-AKT-mTOR pathway PMID: 24379119
    8. CCL-18 and IGFBP-6 were identified as new potential serum biomarkers for prostate cancer. PMID: 24747338
    9. When the concentrations of IGFBP-6 or KNG1 were greater than 98.5 pg/ml or 88.5 ng/ml, respectively, they predicted the proliferative vitreoretinopathy prognosis. PMID: 23808406
    10. Data indicate that IGFBP-6 binds to prohibitin-2 on the cell membrane, and knockdown of the latter abrogates IGFBP-6-induced migration. PMID: 24003225
    11. Review of the IGF system in physiology and disease with a focus on the regulation and actions of IGFBP-6, and its potential roles in cancer cells. PMID: 23126425
    12. These results suggest that the expression of IGFBP-6 in vascular endothelial cells is up-regulated by hypoxia and IGFBP-6 inhibits angiogenesis in vitro and in vivo PMID: 21618524
    13. IGFBP-6 acts as a inhibitory mediator of thyroid hormone effects in osteoblast differentiation PMID: 21997736
    14. TCDD at low concentrations may have a negative effect on cell apoptosis and down-regulate gene expression of IGFBP-6 in SaOS-2 cells. PMID: 18724896
    15. Hh pathway is aberrant activation in colorectal carcinoma cell line. Its inhibitor may be effectual agent for colorectal cancer chemoprevention. Gli1 maintained cell survival by binding promoter regions and facilitating transcription of IGFBP6 and Bcl-2. PMID: 21940310
    16. When IGFBP-6 gene expression was downregulated, cell proliferation was inhibited and apoptotic cell death was increased. PMID: 21820463
    17. Kininogen-1 and IGFBP-6 are expressed in serum and vitreous humor in proliferative vitreoretinopathy patients. PMID: 21054968
    18. IGFBP-6 inhibits osteoblastic differentiation mediated by vitamin d3 by directly binding the vitamin d receptor and inhibiting its function PMID: 21458526
    19. These results indicate that IGFBP-6 promotes Rh30 rhabdomyosarcoma chemotaxis in an IGF-independent manner, and that MAPK signaling pathways and their cross-talk play an important role in this process. PMID: 20432455
    20. Inhibition of human osteoblast marker gene expression by retinoids is mediated in part by insulin-like growth factor binding protein-6. PMID: 11914024
    21. may function as an antiproliferative molecule suppressing mitogenic effects of insulin-like growth factors on Malassez cells PMID: 12558805
    22. CCI-779 acts additively with IGFBP-6 to reduce rhabdomyosarcoma growth both in vitro and in vivo. PMID: 14710364
    23. C-domain of IGFBP-6 consists of a thyroglobulin type 1 fold comprising an alpha-helix followed by a loop, a three-stranded antiparallel beta-sheet incorporating a second loop, and a disulfide-bonded flexible third loop. PMID: 15308688
    24. A close correlation exists between residues of the carboxyl-terminal domain of IGFBP6 undergoing conformational change in 15N NMR spectroscopy studies with those that disappeared or broadened upon insulin-like growth factor (IGF-II) binding. PMID: 15366928
    25. The IGFBP-6 protein is synthesized as propeptides with a hydrophobic leader sequence, removal of which yields a mature protein composed of 3 recognizable domains of similar size. PMID: 15797461
    26. transgenic human IGFBP-6 mice may be considered a new tool for studies of the involvement of the brain IGF system in metabolism control and obesity. PMID: 15889232
    27. p38 MAPK is involved in IGFBP-6-induced IGF-independent rhabdomyosarcoma cell migration PMID: 17519236
    28. Toxic effect of TCDD on osteogenesis through altering IGFBP6 gene expression in osteoblasts is reported. PMID: 17978469
    29. IGFBP-6 is translocated to the nucleus with functional consequences, and different members of the IGFBP family have specific nuclear import mechanisms. PMID: 18039785
    30. These studies provide evidence that overexpression of IGFBP-6 suppresses human and murine osteoblast differentiation, that IGFBP-6 and LMP-1 physically interact, and supports the conclusion that this interaction may be functionally relevant. PMID: 18395833
    31. bexarotene increased the occupancy of the identified enhancer element in IGFBP-6 gene by RXRalpha, RARbeta, cJun, cFos, and p300 PMID: 18957410
    32. Data show that an increase in JNK activation in the presence of NFkappaB inhibition significantly increased the expression of IGFBP6. PMID: 18982452
    33. IGFBP-6 is the effector of tumor suppressor activity of SEMA3B. PMID: 18985860

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 數據庫鏈接:

    HGNC: 5475

    OMIM: 146735

    KEGG: hsa:3489

    STRING: 9606.ENSP00000301464

    UniGene: Hs.274313



主站蜘蛛池模板: 日本一区二区在线播放| 欧美成人形色生活片| 人妻少妇久久中文字幕| 在线亚洲中文精品第1页| 真人作爱90分钟免费看视频| 午夜天堂精品久久久久| 国产一区二区三区在线蜜桃| 男女啪啪抽搐呻吟高潮动态图| 欧美国产日本高清不卡| 国产95在线 | 亚洲| 久久亚洲a片com人成| 亚洲аv电影天堂网| 国产成人剧情av麻豆果冻| 97精品尹人久久大香线蕉| 男女啪啪进出阳道猛进| 日韩精品久久无码中文字幕 | 精品人妻无码专区中文字幕| 最新版天堂资源中文官网| 午夜性刺激在线视频免费| 久久国产精品久久精品国产| 国产麻豆剧果冻传媒一区| 曰批免费视频播放免费直播| 少妇人妻精品无码专区视频| 国产热の有码热の无码视频| 浮妇高潮喷白浆视频| 人人狠狠久久亚洲综合88| 精品无码专区亚洲| 国产午夜视频在线观看| 精品亚洲国产成人a片app| 中文字幕av无码免费一区| 男男车车的车车网站w98免费| 国产精品久久久久久久| 国产精品人妻系列21p| 国产精品亚洲第一区在线观看| 色狠狠色狠狠综合天天| 人妻丰满熟妇av无码区hd| 亚洲熟妇av一区二区三区宅男| 久久久久久无码午夜精品直播 | 2021少妇久久久久久久久久| 亚洲另类激情综合偷自拍图| 波多野结衣一区二区三区高清|