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IDH3A Antibody

  • 中文名稱：
    IDH3A兔多克隆抗體
  • 貨號：
    CSB-PA005463
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of MCF-7 HT29 mouse brain mouse heart mouse colon mouse kidney mouse skeletal muscle cells using IDH3A Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    IDH3A
  • 別名：
    H IDH alpha antibody; HIDH alpha antibody; IDH3A antibody; IDH3A_HUMAN antibody; Isocitrate dehydrogenase (NAD+) alpha chain precursor antibody; Isocitrate dehydrogenase [NAD] subunit alpha antibody; Isocitrate dehydrogenase [NAD] subunit alpha mitochondrial antibody; Isocitrate dehydrogenase 3 (NAD+) alpha antibody; Isocitrate dehydrogenase antibody; Isocitric dehydrogenase antibody; Isocitric dehydrogenase subunit alpha antibody; mitochondrial antibody; NAD antibody; NAD(+)-specific ICDH subunit alpha antibody; NAD(H) specific isocitrate dehydrogenase alpha subunit precursor antibody; NAD+ specific ICDH antibody; NADsubunit alpha mitochondrial precursor antibody; OTTHUMP00000184906 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human IDH3A.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
  • 基因功能參考文獻(xiàn)：
    1. The silencing of IDH3a significantly delayed tumor growth by suppressing the HIF-1-mediated Warburg effect and angiogenesis. PMID: 25531325
    2. for IDH, a normal alpha subunit is required for catalytic activity and alpha-Arg88 likely participates in the isocitrate site, whereas the beta and gamma subunits have roles in the nucleotide functions of this allosteric enzyme PMID: 14555658
    3. active sites of the human NAD-IDH are shared between alpha and gamma subunits and between alpha and beta subunits PMID: 16737955
    4. Asp181 is essential for nicotinamide-adenine dinucleotide (NAD)-specific IDH alpha subunit catalysis and may also facilitate the binding of substrates. PMID: 17432878
  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    Isocitrate and isopropylmalate dehydrogenases family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5384

    OMIM: 601149

    KEGG: hsa:3419

    STRING: 9606.ENSP00000299518

    UniGene: Hs.591110



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