在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ICK Antibody

  • 中文名稱:
    ICK兔多克隆抗體
  • 貨號(hào):
    CSB-PA010955GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    ICK
  • 別名:
    CILK1 antibody; ICK antibody; KIAA0936Serine/threonine-protein kinase ICK antibody; EC 2.7.11.1 antibody; Ciliogenesis associated kinase 1 antibody; Intestinal cell kinase antibody; hICK antibody; Laryngeal cancer kinase 2 antibody; LCK2 antibody; MAK-related kinase antibody; MRK antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ICK
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Required for ciliogenesis. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a key role in the development of multiple organ systems and particularly in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity.
  • 基因功能參考文獻(xiàn):
    1. Our data provide evidence that heterozygous variants in ICK caused juvenile myoclonic epilepsy in 7% of the patients included in our analysis. Variant ICK affects cell processes that help explain microdysgenesis and polyspike networks observed on EEG in juvenile myoclonic epilepsy. PMID: 29539279
    2. These data identify ICK as an short rib polydactyly syndromes (SRPS)-associated gene and reveal that abnormalities in signalling pathways contribute to defective skeletogenesis PMID: 27466187
    3. findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress. PMID: 25184386
    4. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. PMID: 24244486
    5. In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation. PMID: 23743448
    6. High ICK expression is associated with prostate cancer. PMID: 22761715
    7. an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor Thr-908. PMID: 22356909
    8. ICK may play a role in the development of multiple organ systems. R272Q has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function since the R272Q mutant fails to localize at the nucleus and has diminished kinase activity PMID: 19185282
    9. Findings demonstrate an important role for ICK in proliferation and differentiation of intestinal epithelial cells. PMID: 19696144
    10. ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. PMID: 20459822
    11. PP5 (protein phosphatase 5)and CCRK (cell cycle-related kinase) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe, an essential regulator of proliferation and apoptosis during mammalian development. PMID: 16954377
    12. ICK plays an important role in the regulation of proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating expression of cell cycle regulators cyclin D1, c-Myc and p21Cip1. PMID: 19696144
    13. ICK is the prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs. PMID: 15988018

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Endocrine-cerebroosteodysplasia (ECO)
  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.; [Isoform 2]: Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 組織特異性:
    Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 21219

    OMIM: 612325

    KEGG: hsa:22858

    STRING: 9606.ENSP00000263043

    UniGene: Hs.417022



主站蜘蛛池模板: 国产无夜激无码av毛片| 一区二区三区四区在线不卡高清| 无码纯肉动漫在线观看| 国语对白嫖老妇胖老太| 亚洲欧洲国产成人综合在线观看| 国产三级在线观看完整版| 无码精品视频一区二区三区| 男女啪啪做爰高潮免费网站| 女人被狂c到高潮视频网站| 在线视频免费无码专区| 一边吃奶一边添p好爽高清视频| 欧美成人国产精品高潮| 无码专区人妻系列日韩精品少妇| a片在线免费观看| 国产欧美在线一区二区三 | 无码三级中文字幕在线观看| 日本在线视频www色| 欧美日韩色另类综合| 亚洲精品一区中文字幕乱码| 少妇激情av一区二区三区| 在线观看高清黄网站观看| 免费观看又色又爽又湿的软件 | 国产精品va无码二区| 影音先锋每日av色资源站| 久久无码人妻精品一区二区三区 | 久久天天躁狠狠躁夜夜爽| 国产啪精品视频网站| 色妞色视频一区二区三区四区| 国产成人综合亚洲色就色| 国产精品乱子伦xxxx| 中文字幕欧美亚州视频免费 | 天天爽夜夜爽人人爽免费| 欧美老妇与zozoz0交| 老牛精品亚洲成av人片| 孕妇怀孕高潮潮喷视频孕妇| 亚洲色无码专区在线观看| 丝袜 亚洲 另类 欧美 变态| 国产欧美综合一区二区三区| 免费高清av一区二区三区| 无遮挡18禁啪啪免费观看| 精品成人av一区二区三区|