在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ICK Antibody, Biotin conjugated

  • 中文名稱:
    ICK兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA891800LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ICK Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ICK
  • 別名:
    CILK1 antibody; ICK antibody; KIAA0936Serine/threonine-protein kinase ICK antibody; EC 2.7.11.1 antibody; Ciliogenesis associated kinase 1 antibody; Intestinal cell kinase antibody; hICK antibody; Laryngeal cancer kinase 2 antibody; LCK2 antibody; MAK-related kinase antibody; MRK antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Serine/threonine-protein kinase ICK protein (150-275AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Required for ciliogenesis. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a key role in the development of multiple organ systems and particularly in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity.
  • 基因功能參考文獻:
    1. Our data provide evidence that heterozygous variants in ICK caused juvenile myoclonic epilepsy in 7% of the patients included in our analysis. Variant ICK affects cell processes that help explain microdysgenesis and polyspike networks observed on EEG in juvenile myoclonic epilepsy. PMID: 29539279
    2. These data identify ICK as an short rib polydactyly syndromes (SRPS)-associated gene and reveal that abnormalities in signalling pathways contribute to defective skeletogenesis PMID: 27466187
    3. findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress. PMID: 25184386
    4. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. PMID: 24244486
    5. In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation. PMID: 23743448
    6. High ICK expression is associated with prostate cancer. PMID: 22761715
    7. an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor Thr-908. PMID: 22356909
    8. ICK may play a role in the development of multiple organ systems. R272Q has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function since the R272Q mutant fails to localize at the nucleus and has diminished kinase activity PMID: 19185282
    9. Findings demonstrate an important role for ICK in proliferation and differentiation of intestinal epithelial cells. PMID: 19696144
    10. ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. PMID: 20459822
    11. PP5 (protein phosphatase 5)and CCRK (cell cycle-related kinase) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe, an essential regulator of proliferation and apoptosis during mammalian development. PMID: 16954377
    12. ICK plays an important role in the regulation of proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating expression of cell cycle regulators cyclin D1, c-Myc and p21Cip1. PMID: 19696144
    13. ICK is the prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs. PMID: 15988018

    顯示更多

    收起更多

  • 相關疾病:
    Endocrine-cerebroosteodysplasia (ECO)
  • 亞細胞定位:
    Nucleus. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.; [Isoform 2]: Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 組織特異性:
    Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
  • 數據庫鏈接:

    HGNC: 21219

    OMIM: 612325

    KEGG: hsa:22858

    STRING: 9606.ENSP00000263043

    UniGene: Hs.417022



主站蜘蛛池模板: 天天弄天天模| 国产 国语对白 露脸| 乱人伦中文字幕成人网站在线 | 国产精品香蕉在线的人| 老司机久久99久久精品播放免费| 久久九九精品国产免费看小说| 国产精品久久久久久2021| 精品国产乱码久久久久久郑州公司 | 国产熟妇勾子乱视频| 亚洲美女高清aⅴ视频免费| 人妻无码中字在线a| 久久久久久久久久久久| 护士的小嫩嫩好紧好爽| 韩国19禁主播深夜福利视频| 国产99久久精品一区二区| 45分钟免费真人视频| 国产精品无码专区久久久| 成在人线av无码免费看网站直播| 亚洲精品一区二区三区中文字幕| 玩弄放荡人妻一区二区三区| 无码一区18禁3d| 在线观看免费视频网站a站| 青草草在线视频永久免费| 韩国三级hd中文字幕| 中文字幕精品亚洲无线码vr| 无码午夜人妻一区二区三区不卡视频 | 超碰97人人射妻| 亚洲欧美日韩在线码| 国语自产偷拍精品视频蜜芽| 豆国产95在线 | 亚洲| 日本肉体xxxx裸体137大胆| 99久久无码一区人妻a片潘金莲| 亚洲精品亚洲人成在线下载 | www婷婷av久久久影片| www国产成人免费观看视频| 狠人干练合综合网| 亚洲色无码播放| 免费精品国产人妻国语| 亚洲国产成人久久综合人| 亚洲s久久久久一区二区| 牛牛视频一区二区三区|