在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Has2 Antibody

  • 中文名稱:
    Has2兔多克隆抗體
  • 貨號:
    CSB-PA010140LA01MO
  • 規格:
    ¥440
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Mus musculus (Mouse) Has2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    Has2
  • 別名:
    Has2 antibody; Hyaluronan synthase 2 antibody; EC 2.4.1.212 antibody; Hyaluronate synthase 2 antibody; Hyaluronic acid synthase 2 antibody; HA synthase 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Mouse
  • 免疫原:
    Recombinant Mouse Hyaluronan synthase 2 protein (67-374AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,Has2 Antibody (CSB-PA010140LA01MO),的標記方式是Non-conjugated。對于Has2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA010140LB01MO Has2 Antibody, HRP conjugated ELISA
    FITC CSB-PA010140LC01MO Has2 Antibody, FITC conjugated
    Biotin CSB-PA010140LD01MO Has2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix.
  • 基因功能參考文獻:
    1. allergen-challenged mice that overexpress HAS2 in myofibroblasts and smooth muscle cells develop increased airway fibrosis, which lessens airway hyperresponsiveness to bronchoconstrictors. PMID: 28787175
    2. Expression of the innate immune receptor Toll-like receptor 4 (TLR4) and the extracellular matrix glycosaminoglycan hyaluronan (HA) on type 2 alveolar epithelial cells (AEC@2) are important for AEC2 renewal, repair of lung injury and limiting the extent of fibrosis. Either deletion of TLR4 or HA synthase 2 in surfactant-protein-C-positive AEC2s leads to impaired renewal capacity, severe fibrosis and mortality. PMID: 27694932
    3. Has2 mRNA was expressed in the surrounding mesenchyme from E12.0 to 18.0 in both molar and incisor tooth germs, but disappeared after birth. PMID: 27289075
    4. the ineffective repair of injured cartilage in Has1(-/-) joints can be at least partly explained by the markedly enhanced expression of particular genes in pathways linked to ECM turnover, IL-17/IL-6 cytokine signaling, and apoptosis. PMID: 26521733
    5. these results highlight the role of nSMase2 in apoptosis evoked by nutrient starvation that could contribute to the delayed apoptosis of hypertrophic chondrocytes in the growth plate, and emphasize the antiapoptotic properties of HAS2 PMID: 25555205
    6. mir-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging. PMID: 25264594
    7. Has2 expression and hyaluronan produced at the tips of epithelial cells play a critical role in driving tubulogenesis and branching in vitro. PMID: 25163516
    8. Hyaluronan synthase 2 has a role in protecting skin fibroblasts against apoptosis induced by environmental stress PMID: 25266724
    9. Stimulation with LPS caused rapid increases in versican mRNA and protein, a rapid increase in Has1 mRNA, and concomitant inhibition of hyaluronidases 1 and 2, the major hyaluronan degrading enzymes PMID: 24472738
    10. This study demonistrated that Has2 expression in adult mouse subventricular zone and rostral migratory stream and in ischemic cortex. PMID: 23391595
    11. This study identifies Has2 as a novel downstream target of Shh signaling required for joint patterning and chondrogenesis. PMID: 23313125
    12. HAS2 was significantly upregulated at the level of gene expression during muscle hypertrophy. PMID: 22785117
    13. NSMase2/Cer are the key mediators of the regulation of HA synthesis, via microdomains and the Akt/mTOR pathway PMID: 22383528
    14. Inhibition of Has2 expression and extracellular hyaluronic acid production requires MiR23 in the embryonic heart to restrict endocardial cushion formation. PMID: 21778427
    15. Data show that Has2 knockout mice died near birth and displayed severe abnormality in skeletal development. PMID: 21224752
    16. PDGF-BB stimulates cultured cardiomyocytes to synthesize the extracellular matrix component hyaluronan via HAS2 PMID: 21200430
    17. Data suggest that hyaluronan production by Has2 in chondrocytes is not only essential for formation of an organized growth plate and subsequent long bone growth but also for normal modeling of the diaphyseal bone. PMID: 21246657
    18. hyaluronan synthase 2 activity is regulated by dimerization and ubiquitination PMID: 20507985
    19. Expression of the mouse HAS2 gene in Drosophila tissues by the Gal4/UAS system resulted in massive HA accumulation in the extracellular space,supporting the idea that in vivo HA biosynthesis does not require molecules other than the HAS protein PMID: 14966127
    20. Has2 expression was impaired in oocyte-cumulus cell complexes in knockout mice. PMID: 15531364
    21. strongly, albeit transiently, expressed in numerous embryonic tissues PMID: 15765504
    22. natural antisense mRNAs of HAS2 may have an important and novel regulatory role in the control of HAS2, hyaluronan biosynthesis, and HA-dependent cell functions PMID: 15843373
    23. Has2 deficiency illustrates the crucial role of hyaluronan in skeletal growth, patterning, chondrocyte maturation and synovial joint formation in the developing limb. PMID: 19633173
    24. Tbx2, a central intermediary of Bmp-Smad signaling, has a central part in directing Has2 and Tgfbeta2 expression, facilitating endocardial cushions formation. PMID: 19846762

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    NodC/HAS family
  • 組織特異性:
    Expressed in heart, brain, spleen, lung and skeletal muscle.
  • 數據庫鏈接:


主站蜘蛛池模板: 96亚洲精华国产精华精华液| 暖暖视频日本| 下面一进一出好爽视频| 国产精品无码免费播放| 亚洲男女羞羞无遮挡久久丫| 又色又爽又高潮免费观看| 人妻无码一区二区三区av| 国产成人精品免费视频大全五级 | 天天做天天爱天天要天天| 18禁止午夜福利体验区| 国产成_人_综合_亚洲_国产| 久久国产精品久久精品国产| 中文字幕乱码中文乱码777| 国自产拍偷拍精品啪啪模特| 夜夜欢性恔免费视频| 超清精品丝袜国产自在线拍| 伊人久久大香线蕉综合75| 欧美精品久久天天躁| 国产亚洲色婷婷久久99精品 | 色欲久久久天天天综合网精品| 一边啪啪的一边呻吟声口述| 亚洲a∨精品无码一区二区| 国产福利一区二区三区在线视频| 成人精品一区日本无码网| 久久国产36精品色熟妇| 失禁潮痉挛潮喷av在线无码 | 成人无码嫩草影院| 久久精品中文字幕第一页| 无码视频在线观看| 92国产精品午夜福利| 国产精品美脚玉足脚交欧美| 久久久774这里只有精品17| 日本又黄又爽gif动态图| 窝窝午夜理论片影院| 色翁荡息又大又硬又粗又爽电影| 欧美制服丝袜人妻另类| 国产在线精品一品二区| 男人j桶进女人p无遮挡免费观看| 性欧美老人牲交xxxxx视频| 日韩在线一区二区不卡视频| 最新国产精品久久精品|