在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Has2 Antibody, FITC conjugated

  • 中文名稱:
    Has2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA010140LC01MO
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Mus musculus (Mouse) Has2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    Has2
  • 別名:
    Has2 antibody; Hyaluronan synthase 2 antibody; EC 2.4.1.212 antibody; Hyaluronate synthase 2 antibody; Hyaluronic acid synthase 2 antibody; HA synthase 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Mouse
  • 免疫原:
    Recombinant Mouse Hyaluronan synthase 2 protein (67-374AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix.
  • 基因功能參考文獻:
    1. allergen-challenged mice that overexpress HAS2 in myofibroblasts and smooth muscle cells develop increased airway fibrosis, which lessens airway hyperresponsiveness to bronchoconstrictors. PMID: 28787175
    2. Expression of the innate immune receptor Toll-like receptor 4 (TLR4) and the extracellular matrix glycosaminoglycan hyaluronan (HA) on type 2 alveolar epithelial cells (AEC@2) are important for AEC2 renewal, repair of lung injury and limiting the extent of fibrosis. Either deletion of TLR4 or HA synthase 2 in surfactant-protein-C-positive AEC2s leads to impaired renewal capacity, severe fibrosis and mortality. PMID: 27694932
    3. Has2 mRNA was expressed in the surrounding mesenchyme from E12.0 to 18.0 in both molar and incisor tooth germs, but disappeared after birth. PMID: 27289075
    4. the ineffective repair of injured cartilage in Has1(-/-) joints can be at least partly explained by the markedly enhanced expression of particular genes in pathways linked to ECM turnover, IL-17/IL-6 cytokine signaling, and apoptosis. PMID: 26521733
    5. these results highlight the role of nSMase2 in apoptosis evoked by nutrient starvation that could contribute to the delayed apoptosis of hypertrophic chondrocytes in the growth plate, and emphasize the antiapoptotic properties of HAS2 PMID: 25555205
    6. mir-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging. PMID: 25264594
    7. Has2 expression and hyaluronan produced at the tips of epithelial cells play a critical role in driving tubulogenesis and branching in vitro. PMID: 25163516
    8. Hyaluronan synthase 2 has a role in protecting skin fibroblasts against apoptosis induced by environmental stress PMID: 25266724
    9. Stimulation with LPS caused rapid increases in versican mRNA and protein, a rapid increase in Has1 mRNA, and concomitant inhibition of hyaluronidases 1 and 2, the major hyaluronan degrading enzymes PMID: 24472738
    10. This study demonistrated that Has2 expression in adult mouse subventricular zone and rostral migratory stream and in ischemic cortex. PMID: 23391595
    11. This study identifies Has2 as a novel downstream target of Shh signaling required for joint patterning and chondrogenesis. PMID: 23313125
    12. HAS2 was significantly upregulated at the level of gene expression during muscle hypertrophy. PMID: 22785117
    13. NSMase2/Cer are the key mediators of the regulation of HA synthesis, via microdomains and the Akt/mTOR pathway PMID: 22383528
    14. Inhibition of Has2 expression and extracellular hyaluronic acid production requires MiR23 in the embryonic heart to restrict endocardial cushion formation. PMID: 21778427
    15. Data show that Has2 knockout mice died near birth and displayed severe abnormality in skeletal development. PMID: 21224752
    16. PDGF-BB stimulates cultured cardiomyocytes to synthesize the extracellular matrix component hyaluronan via HAS2 PMID: 21200430
    17. Data suggest that hyaluronan production by Has2 in chondrocytes is not only essential for formation of an organized growth plate and subsequent long bone growth but also for normal modeling of the diaphyseal bone. PMID: 21246657
    18. hyaluronan synthase 2 activity is regulated by dimerization and ubiquitination PMID: 20507985
    19. Expression of the mouse HAS2 gene in Drosophila tissues by the Gal4/UAS system resulted in massive HA accumulation in the extracellular space,supporting the idea that in vivo HA biosynthesis does not require molecules other than the HAS protein PMID: 14966127
    20. Has2 expression was impaired in oocyte-cumulus cell complexes in knockout mice. PMID: 15531364
    21. strongly, albeit transiently, expressed in numerous embryonic tissues PMID: 15765504
    22. natural antisense mRNAs of HAS2 may have an important and novel regulatory role in the control of HAS2, hyaluronan biosynthesis, and HA-dependent cell functions PMID: 15843373
    23. Has2 deficiency illustrates the crucial role of hyaluronan in skeletal growth, patterning, chondrocyte maturation and synovial joint formation in the developing limb. PMID: 19633173
    24. Tbx2, a central intermediary of Bmp-Smad signaling, has a central part in directing Has2 and Tgfbeta2 expression, facilitating endocardial cushions formation. PMID: 19846762

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    NodC/HAS family
  • 組織特異性:
    Expressed in heart, brain, spleen, lung and skeletal muscle.
  • 數據庫鏈接:


主站蜘蛛池模板: 久无码久无码av无码| 亚洲自偷自拍另类11p| 国产成人免费永久在线平台| 无码人妻一区二区三区免费看| 男女同房做爰爽免费| 亚洲欧洲自拍拍偷精品网| 欧美黑人xxxx性高清版| 黑人巨大精品欧美一区二区| 曰韩少妇内射免费播放| 国产成人av国语在线观看 | 少妇下面好紧好多水真爽播放| 国产精品亚洲成在人线| 免费va人成视频网站全| 加勒比东京热无码一区| 国产精品免费精品自在线观看| 香港日本三级亚洲三级| 人妻少妇精品视中文字幕国语| 日韩无套无码精品| 一边摸一边做爽的免费视频日本| 国产成a人亚洲精v品无码性色| 久久久久国产精品人妻| 国产欲女高潮正在播放| 久久露脸国产精品| 无码人妻丰满熟妇区bbbbxxxx| 国产精品久久久av久久久| 高清不卡毛片免费观看| 色欲综合久久中文字幕网| 欧美性色19p| 人妻激情偷乱一区二区三区| 免费看女人与公拘交酡过程| 精品一二三区久久aaa片| 国产精品沙发午睡系列990531| 欧美性猛交xxx嘿人猛交| 成人福利国产精品视频| 情侣黄网站免费看| 无码中文av有码中文a| 久久天天躁狠狠躁夜夜2020老熟妇 | 99精品热这里只有精品| 麻豆果冻传媒2021精品传媒一区下载| 88国产精品视频一区二区三区| 狠狠久久噜噜熟女|