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  4. HTATSF1 Antibody

HTATSF1 Antibody

  • 中文名稱：
    HTATSF1兔多克隆抗體
  • 貨號：
    CSB-PA010872GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    HTATSF1
  • 別名：
    HTATSF1HIV Tat-specific factor 1 antibody; Tat-SF1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human HTATSF1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.
  • 基因功能參考文獻：
    1. This study validates Tat-SF1 as an HDF in CD4+ T cell-derived SupT1 cells. PMID: 23153325
    2. these findings suggest that Tat-SF1 functions independently in transcription and splicing of cellular genes. PMID: 21282347
    3. These results support the notion that Tat-induced neuropathogenesis is mediated by multiple mechanisms involving both intracellular and extracellular Tat protein. PMID: 15050687
    4. phosphorylated by P-TEFb kinase during HIV-1 transcription in Tat/TAR dependent manner PMID: 15564463
    5. Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1 PMID: 16512786
    6. Tat-SF1 is not required for regulating HIV-1 transcription, but is required for maintaining the ratios of different classes of HIV-1 transcripts. PMID: 19479034

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    HTATSF1 family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 5276

    OMIM: 300346

    KEGG: hsa:27336

    STRING: 9606.ENSP00000218364

    UniGene: Hs.204475



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