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  4. HSBP1 Antibody, Biotin conjugated

HSBP1 Antibody, Biotin conjugated

  • 中文名稱：
    HSBP1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA00454D0Rb
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HSBP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Heat shock factor binding protein 1 antibody; Heat shock factor-binding protein 1 antibody; HSBP1 antibody; HSBP1_HUMAN antibody; HSF1BP antibody; Nasopharyngeal carcinoma associated antigen 13 antibody; Nasopharyngeal carcinoma-associated antigen 13 antibody; NPC A 13 antibody; NPC-A-13 antibody; NPCA 13 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Heat shock factor-binding protein 1 protein (1-75AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
  • 基因功能參考文獻：
    1. HSPB1 protects cells against proapoptotic agents when expressed at high level, while inhibition of its expression has been found to predispose cells to apoptosis. PMID: 28828227
    2. Results presented here show that acquisition of a positive charge in HSBP1, either by protonation of His124 or its substitution by lysine, reduces the stability of the dimer interface of the alpha-crystallin domain, increases oligomeric size, and modestly increases chaperone activity. PMID: 28332148
    3. HSBP1 is crucial for regulating resistance to radiotherapy of oral squamous epithelial carcinoma cells by inducing stem-like status. PMID: 24816843
    4. HspBP1 inhibited the cytotoxic activity of the Tag7-Hsp70 complex secreted by lymphocytes. HspBP1 PMID: 21247889
    5. This study reports the crystal structure of a degradation-resistant fragment of HSBP1. A continuous, long-helix conformation of HSBP1 assembles into a coiled-coil three-helix bundle and subsequently into an elongated, symmetrical hexamer. PMID: 18767159
    6. HSBP likely mediates its function through its trimerization domain. PMID: 11679589

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    HSBP1 family
  • 數據庫鏈接：

    HGNC: 5203

    OMIM: 604553

    KEGG: hsa:3281

    STRING: 9606.ENSP00000392896

    UniGene: Hs.250899



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