在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HNRNPH1 Antibody

  • 中文名稱:
    HNRNPH1兔多克隆抗體
  • 貨號(hào):
    CSB-PA010609GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    HNRNPH1
  • 別名:
    DKFZp686A15170 antibody; Heterogeneous nuclear ribonucleoprotein H antibody; Heterogeneous nuclear ribonucleoprotein H1 (H) antibody; Heterogeneous nuclear ribonucleoprotein H1 antibody; HNRH1_HUMAN antibody; hnRNP H antibody; hnRNPH antibody; Hnrnph1 antibody; HNRPH 1 antibody; HNRPH antibody; HNRPH1 protein antibody; N-terminally processed antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human HNRNPH1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).
  • 基因功能參考文獻(xiàn):
    1. Together, these data implicate C9ORF72 GGGGCC expansion-mediated sequestration of hnRNP H as a significant contributor to neurodegeneration in C9 amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. PMID: 27623008
    2. High HNRNPH1 expression is associated with castration-resistant prostate cancer. PMID: 28844715
    3. hnRNP H binds to two specific G-runs in exon 5a of ACHE and activates the distal alternative 3 splice site (ss) between exons 5a and 5b. Furthermore, hnRNP H competes for binding of CstF64 to the overlapping binding sites in exon 5a, and suppresses the selection of a cryptic polyadenylation site, which additionally ensures transcription of the distal 3 ss required for the generation of AChET isoform. PMID: 28180311
    4. The different alternative transcript variants of HNRNPH1 exhibited different expression changes during tumorigenesis. Its mRNA and protein were overexpressed in esophageal squamous cell carcinoma and associated with poorer differentiation of tumor cells. PMID: 27621578
    5. Our findings define novel roles for hnRNPH1 as a putative oncogene, splicing factor, and an auxiliary AR coregulator. PMID: 26553749
    6. Global splicing analysis with RNA-seq revealed that exons carrying the hnRNP H-binding GGGGG motif are predisposed to be skipped compared to those carrying the SRSF1-binding GGAGG motif in both human and mouse brains. PMID: 26282582
    7. vRSF3 and hnRNP H1 are the first splicing factors identified which regulate the production of these functionally distinct HER2 splice variants and therefore maybe important for the regulation of HER2 signaling. PMID: 26367347
    8. In pediatric T-acute lymphoblastic leukemia, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp11.3 as new MLLT10 fusion partners. PMID: 23673860
    9. These results support a working hypothesis that a late viral protein HPV16 L1, which is down regulated by hnRNP H early in the viral life cycle may provide an auto-regulatory positive feedback loop that allows the rapid production of HPV capsid proteins through suppression of the function of hnRNP H at the late stage of the viral life cycle. PMID: 23261416
    10. The REST N exon is a very versatile sequence with a complex array of splicing signals, and its activation in H69 cells depends on the relative amounts of hnRNP H and U2AF65. PMID: 22792276
    11. These results suggest that increased level of hnRNP-H and PDIA3 expression in Dengue virus infected THP1 cells assist in the viral replication by suppressing the TNF-alpha production. PMID: 22207023
    12. hnRNPH activity appears to be involved in the pathogenesis and progression of malignant gliomas as the centre of a splicing oncogenic switch PMID: 21915099
    13. spatial interactions of hnRNPH1, NF45, and C14orf166 with HCVc174 likely modulate HCV or cellular functions during acute and chronic HCV infection PMID: 21823664
    14. Insight on the crucial role of hnRNP H1 in the regulation of the alternative splicing of the rpL3 gene. PMID: 21705779
    15. Nuclear heterogeneous nuclear ribonucleo-protein H expression was related to survival in colorectal cancer. PMID: 21194727
    16. altered function of hnRNP H1/H2 in tumor cells is a novel determinant of aberrant thymidine phosphorylase splicing thereby resulting in acquired chemoresistance to TP-activated fluoropyrimidine anticancer drugs. PMID: 21068389
    17. the G-stretches within exon 9B regulate RAGE alternative splicing via interaction with hnRNP H PMID: 20028692
    18. working model in which rpL3 recruits hnRNP H1 and, through cooperation with other splicing factors, promotes selection of the alternative splice site PMID: 20100605
    19. A-Raf prevents cancer cell apoptosis contingent on the expression of the heterogeneous nuclear ribonucleoprotein H (hnRNP H) splice factor, which is required for the correct transcription and expression of a-raf. PMID: 20145135
    20. the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. PMID: 19425502

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus, nucleoplasm.
  • 組織特異性:
    Expressed ubiquitously.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 5041

    OMIM: 601035

    KEGG: hsa:3187

    STRING: 9606.ENSP00000349168

    UniGene: Hs.604001



主站蜘蛛池模板: 男男女女爽爽爽免费视频| 四虎永久地址www成人| 搡老岳熟女国产熟妇| 欧美午夜理伦三级在线观看| 成年轻人电影免费无码| 最近中文字幕mv在线视频2018| 欧美日韩在线视频一区| 亚洲成av人片一区二区密柚| 亚洲色在线v中文字幕| a∨在线视频播放| 性动态图av无码专区| 日韩中文字幕免费视频| 久久精品无码免费不卡 | 国产亚洲精品久久777777 | 麻花传媒mv国产免费观看视频| 久久妇女高潮喷水多| 黑人巨大跨种族video| 无码三级国产三级在线电影| 亚洲中文字幕乱码电影| 137日本免费肉体摄影| 欧美精品v国产精品v日韩精品| 免费毛片全部不收费的| 亚洲色大成网站www永久一区| 国产亚洲精品久久久ai换脸| 免费国产裸体美女视频全黄 | 国产人妻黑人一区二区三区| 99国产成人精品视频| 亚洲 欧美 唯美 国产 伦 综合| 欧美老熟妇xb水多毛多| 在线涩涩免费观看国产精品| 久久无码喷吹高潮播放不卡| 国产亚洲产品影市在线产品 | 久久午夜神器| 亚洲国产午夜精品理论片在线播放 | 成人免费午夜无码视频| 熟妇人妻系列av无码一区二区| 奇米影视777四色狠狠| 少妇mm被擦出白浆液视频| 国产精品毛多多水多| 精品少妇ay一区二区三区| 黑人尾随强伦姧人妻爽翻天|