在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HNRNPH1 Antibody, Biotin conjugated

  • 中文名稱:
    HNRNPH1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA04264D0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HNRNPH1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    HNRNPH1
  • 別名:
    DKFZp686A15170 antibody; Heterogeneous nuclear ribonucleoprotein H antibody; Heterogeneous nuclear ribonucleoprotein H1 (H) antibody; Heterogeneous nuclear ribonucleoprotein H1 antibody; HNRH1_HUMAN antibody; hnRNP H antibody; hnRNPH antibody; Hnrnph1 antibody; HNRPH 1 antibody; HNRPH antibody; HNRPH1 protein antibody; N-terminally processed antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Heterogeneous nuclear ribonucleoprotein H protein (2-216AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).
  • 基因功能參考文獻:
    1. Together, these data implicate C9ORF72 GGGGCC expansion-mediated sequestration of hnRNP H as a significant contributor to neurodegeneration in C9 amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. PMID: 27623008
    2. High HNRNPH1 expression is associated with castration-resistant prostate cancer. PMID: 28844715
    3. hnRNP H binds to two specific G-runs in exon 5a of ACHE and activates the distal alternative 3 splice site (ss) between exons 5a and 5b. Furthermore, hnRNP H competes for binding of CstF64 to the overlapping binding sites in exon 5a, and suppresses the selection of a cryptic polyadenylation site, which additionally ensures transcription of the distal 3 ss required for the generation of AChET isoform. PMID: 28180311
    4. The different alternative transcript variants of HNRNPH1 exhibited different expression changes during tumorigenesis. Its mRNA and protein were overexpressed in esophageal squamous cell carcinoma and associated with poorer differentiation of tumor cells. PMID: 27621578
    5. Our findings define novel roles for hnRNPH1 as a putative oncogene, splicing factor, and an auxiliary AR coregulator. PMID: 26553749
    6. Global splicing analysis with RNA-seq revealed that exons carrying the hnRNP H-binding GGGGG motif are predisposed to be skipped compared to those carrying the SRSF1-binding GGAGG motif in both human and mouse brains. PMID: 26282582
    7. vRSF3 and hnRNP H1 are the first splicing factors identified which regulate the production of these functionally distinct HER2 splice variants and therefore maybe important for the regulation of HER2 signaling. PMID: 26367347
    8. In pediatric T-acute lymphoblastic leukemia, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp11.3 as new MLLT10 fusion partners. PMID: 23673860
    9. These results support a working hypothesis that a late viral protein HPV16 L1, which is down regulated by hnRNP H early in the viral life cycle may provide an auto-regulatory positive feedback loop that allows the rapid production of HPV capsid proteins through suppression of the function of hnRNP H at the late stage of the viral life cycle. PMID: 23261416
    10. The REST N exon is a very versatile sequence with a complex array of splicing signals, and its activation in H69 cells depends on the relative amounts of hnRNP H and U2AF65. PMID: 22792276
    11. These results suggest that increased level of hnRNP-H and PDIA3 expression in Dengue virus infected THP1 cells assist in the viral replication by suppressing the TNF-alpha production. PMID: 22207023
    12. hnRNPH activity appears to be involved in the pathogenesis and progression of malignant gliomas as the centre of a splicing oncogenic switch PMID: 21915099
    13. spatial interactions of hnRNPH1, NF45, and C14orf166 with HCVc174 likely modulate HCV or cellular functions during acute and chronic HCV infection PMID: 21823664
    14. Insight on the crucial role of hnRNP H1 in the regulation of the alternative splicing of the rpL3 gene. PMID: 21705779
    15. Nuclear heterogeneous nuclear ribonucleo-protein H expression was related to survival in colorectal cancer. PMID: 21194727
    16. altered function of hnRNP H1/H2 in tumor cells is a novel determinant of aberrant thymidine phosphorylase splicing thereby resulting in acquired chemoresistance to TP-activated fluoropyrimidine anticancer drugs. PMID: 21068389
    17. the G-stretches within exon 9B regulate RAGE alternative splicing via interaction with hnRNP H PMID: 20028692
    18. working model in which rpL3 recruits hnRNP H1 and, through cooperation with other splicing factors, promotes selection of the alternative splice site PMID: 20100605
    19. A-Raf prevents cancer cell apoptosis contingent on the expression of the heterogeneous nuclear ribonucleoprotein H (hnRNP H) splice factor, which is required for the correct transcription and expression of a-raf. PMID: 20145135
    20. the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. PMID: 19425502

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleoplasm.
  • 組織特異性:
    Expressed ubiquitously.
  • 數據庫鏈接:

    HGNC: 5041

    OMIM: 601035

    KEGG: hsa:3187

    STRING: 9606.ENSP00000349168

    UniGene: Hs.604001



主站蜘蛛池模板: 国产精品无码一区二区在线看| 国内精品久久久久久影院| 草草久久97超级碰碰碰| 东京一本一道一二三区 | 人妻人人做人碰人人添| 超清中文乱码字幕在线观看| 日韩a无v码在线播放| 2019精品国自产拍在线不卡| 精品少妇人妻av免费久久洗澡| 亚洲国产成人综合精品| 永久免费无码成人网站| 一本大道东京热无码视频| 最新日韩精品中文字幕| 国产精品vr专区| 国产成人手机高清在线观看网站 | 国产激情久久久久影院小草| 亚洲中文字幕国产综合| 国产精品成人3p一区二区三区| 欧美xxxx黑人又粗又长精品| 日韩精品无码免费一区二区三区| 国产精品区一区二区三在线播放| 久久综合香蕉国产蜜臀av| 国产精品国产三级国产aⅴ下载| 午夜男女爽爽影院免费视频 | 国产无线乱码一区二三区| 亚洲人成77在线播放网站| 色婷婷av一区二区三区浪潮| 无码福利日韩神码福利片| 亚洲熟女精品中文字幕| 67194熟妇人妻欧美日韩| 无码免费一区二区三区| 久久综合久久鬼色| 中文字幕乱码亚洲无线码三区| 亚洲中文字幕aⅴ天堂| 色先锋av资源中文字幕| 久久精品成人免费国产| 偷拍农村老熟妇xxxxx7视频| 免费无码黄网站在线看| 狂野av人人澡人人添| 色噜噜亚洲男人的天堂www| 小荡货好紧好爽奶头大视频|