在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HLX Antibody

  • 中文名稱:
    HLX兔多克隆抗體
  • 貨號:
    CSB-PA002936
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COLO205 cells using HLX1 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HLX
  • 別名:
    H2.0 like homeo box 1 antibody; H2.0 like homeobox 1 antibody; H2.0 like homeobox 1 Drosophila antibody; H2.0-like homeobox protein antibody; HB24 antibody; HLX antibody; HLX_HUMAN antibody; Homeobox protein HB24 antibody; Homeobox protein HLX1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human HLX1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis.
  • 基因功能參考文獻:
    1. An important association between HLX transcription factor expression and abnormal human placental development in discordant twin pregnancies. PMID: 29212571
    2. HLX is a homeobox transcription factor gene which is relatively conserved across species. Hlx homozygous null mice have a short bowel and reduced muscle cells in the diaphragm, closely resembling the anomalies in the two fetuses and we therefore suggest that the HLX mutation in this family could explain the fetal findings PMID: 28898547
    3. Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT. PMID: 28701693
    4. HLX1 is significantly downregulated in HCC and suggests that HLX1 has suppressive effects on HCC growth and metastasis. Accordingly, HLX1 may act as a tumor suppressor in HCC. PMID: 26631039
    5. Studies have identified HLX as a novel key transcription factor involved in the regulation of early hematopoiesis and AML pathogenesis. PMID: 23888188
    6. The expression levels of Hlx, T-bet, and IFN-gamma were significantly decreased. PMID: 23243425
    7. Data suggest that HLX1 is downstream mediator of hepatocyte growth factor- (HGF-) induced cell survival, cell proliferation, and invasive properties of trophoblast cells; thus, both HGF and HLX1 appear to be involved in normal placental development. PMID: 22989111
    8. This study identifies HLX as a key regulator in immature hematopoietic and leukemia cells and as a prognostic marker and therapeutic target in acute myeloid leukemia. PMID: 22897850
    9. This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth. PMID: 22303482
    10. a functional polymorphism in HLX in combination with the TBX21 polymorphism is also associated with the prognosis of Graves' disease. PMID: 22014209
    11. These data suggest that HLX may function to balance attractive with repulsive vessel guidance by up-regulating UNC5B and to down-modulate sprouting under normoxic conditions. PMID: 21224470
    12. HLX is a mediator of HGF/c-met-dependent trophoblast migration but is not involved in the regulation of trophoblast invsion. PMID: 20554918
    13. Cell cycle regulatory genes RB1, MYC, CCNB1, ELK1, JUN, and CDKN1C, which control important trophoblast cell functions, are targets of HLX. PMID: 20008130
    14. Decreased HLX1 expression is associated with idiopathic fetal growth restriction PMID: 16436665
    15. Hlx expression in activated NK cells temporally controls and limits the monokine-induced production of interferon-gamma. PMID: 17110450
    16. We have shown for the first time that a homeobox gene, HLX1, is a downstream effector gene of CSF-1, that HLX1 regulates placental cell proliferation and that CSF-1 acts, at least in part, through HLX1 to control cell proliferation. PMID: 17532041
    17. HLX is primarily expressed in cytotrophoblast cell types in the human placenta and propose that HLX is involved in cytotrophoblast proliferation and downregulation of cell differentiation PMID: 18402755
    18. polymorphisms in the HLX1 gene increase the risk for childhood asthma. PMID: 19038437
    19. gene variants influence the development of childhood asthma PMID: 19295429
    20. A risk score model indicates that TBX21 and HLX1 polymorphisms may have synergistic effects on asthma risk. PMID: 19362357
    21. Sequence variants in the HLX gene at chromosome 1q41-1q42 in patients with diaphragmatic hernia PMID: 19459883

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    H2.0 homeobox family
  • 組織特異性:
    Low level in normal B and T-cells, high level in activated lymphocytes and monocytes. Also found in thymus, tonsil, bone marrow, developing vessels, and fetal brain.
  • 數據庫鏈接:

    HGNC: 4978

    OMIM: 142995

    KEGG: hsa:3142

    STRING: 9606.ENSP00000355870

    UniGene: Hs.74870



主站蜘蛛池模板: 熟女体下毛毛黑森林| av电影在线观看| 久久www免费人成一看片 | 亚洲精品久久久久中文第一幕| 久久亚洲中文字幕伊人久久大| 日产精品99久久久久久| 熟妇人妻av中文字幕老熟妇| 最新亚洲春色av无码专区| 在线亚洲精品国产一区麻豆| 又爽又黄无遮挡高潮视频网站| 国产老妇伦国产熟女老妇高清| 欧美丰满熟妇xxxx性| 秋霞国产午夜伦午夜福利片| 久久久久免费看成人影片| 国产成人愉拍免费视频| 美女扒开大腿让男人桶| 欧美一区二区日韩国产| 日韩精品人涩人| 国产成人一区二区青青草原| 国产一区二区三区小说| 亚洲欧洲成人av每日更新| 亚洲精品乱码久久久久久日本麻豆| 韩国精品视频一区二区在线播放| 亚洲视频在线观看| 中文乱码免费一区二区| 大狠狠大臿蕉香蕉大视频| 国产精品亚洲色婷婷99久久精品| а√资源新版在线天堂| 秋霞av在线露丝片av无码| 中文无码日韩欧av影视| 亚州av综合色区无码一区| 2012中文字幕在线视频| 国产精品无码永久免费888| 成人免费ā片在线观看| 国产sm主人调教女m视频| 日韩美女自卫慰黄网站| 极品美女扒开粉嫩小泬图片| 久久精品一区二区三区av| 亚洲国产成在人网站天堂| 欧美日产成人高清视频| 久久国产精品二国产精品|