在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HLX Antibody

  • 中文名稱:
    HLX兔多克隆抗體
  • 貨號:
    CSB-PA555384
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from COLO205 cells, using HLX1 antibody.
    • Immunofluorescence analysis of MCF-7 cells, using HLX1 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HLX Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    HLX
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human HLX1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis.
  • 基因功能參考文獻:
    1. An important association between HLX transcription factor expression and abnormal human placental development in discordant twin pregnancies. PMID: 29212571
    2. HLX is a homeobox transcription factor gene which is relatively conserved across species. Hlx homozygous null mice have a short bowel and reduced muscle cells in the diaphragm, closely resembling the anomalies in the two fetuses and we therefore suggest that the HLX mutation in this family could explain the fetal findings PMID: 28898547
    3. Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT. PMID: 28701693
    4. HLX1 is significantly downregulated in HCC and suggests that HLX1 has suppressive effects on HCC growth and metastasis. Accordingly, HLX1 may act as a tumor suppressor in HCC. PMID: 26631039
    5. Studies have identified HLX as a novel key transcription factor involved in the regulation of early hematopoiesis and AML pathogenesis. PMID: 23888188
    6. The expression levels of Hlx, T-bet, and IFN-gamma were significantly decreased. PMID: 23243425
    7. Data suggest that HLX1 is downstream mediator of hepatocyte growth factor- (HGF-) induced cell survival, cell proliferation, and invasive properties of trophoblast cells; thus, both HGF and HLX1 appear to be involved in normal placental development. PMID: 22989111
    8. This study identifies HLX as a key regulator in immature hematopoietic and leukemia cells and as a prognostic marker and therapeutic target in acute myeloid leukemia. PMID: 22897850
    9. This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth. PMID: 22303482
    10. a functional polymorphism in HLX in combination with the TBX21 polymorphism is also associated with the prognosis of Graves' disease. PMID: 22014209
    11. These data suggest that HLX may function to balance attractive with repulsive vessel guidance by up-regulating UNC5B and to down-modulate sprouting under normoxic conditions. PMID: 21224470
    12. HLX is a mediator of HGF/c-met-dependent trophoblast migration but is not involved in the regulation of trophoblast invsion. PMID: 20554918
    13. Cell cycle regulatory genes RB1, MYC, CCNB1, ELK1, JUN, and CDKN1C, which control important trophoblast cell functions, are targets of HLX. PMID: 20008130
    14. Decreased HLX1 expression is associated with idiopathic fetal growth restriction PMID: 16436665
    15. Hlx expression in activated NK cells temporally controls and limits the monokine-induced production of interferon-gamma. PMID: 17110450
    16. We have shown for the first time that a homeobox gene, HLX1, is a downstream effector gene of CSF-1, that HLX1 regulates placental cell proliferation and that CSF-1 acts, at least in part, through HLX1 to control cell proliferation. PMID: 17532041
    17. HLX is primarily expressed in cytotrophoblast cell types in the human placenta and propose that HLX is involved in cytotrophoblast proliferation and downregulation of cell differentiation PMID: 18402755
    18. polymorphisms in the HLX1 gene increase the risk for childhood asthma. PMID: 19038437
    19. gene variants influence the development of childhood asthma PMID: 19295429
    20. A risk score model indicates that TBX21 and HLX1 polymorphisms may have synergistic effects on asthma risk. PMID: 19362357
    21. Sequence variants in the HLX gene at chromosome 1q41-1q42 in patients with diaphragmatic hernia PMID: 19459883

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    H2.0 homeobox family
  • 組織特異性:
    Low level in normal B and T-cells, high level in activated lymphocytes and monocytes. Also found in thymus, tonsil, bone marrow, developing vessels, and fetal brain.
  • 數據庫鏈接:

    HGNC: 4978

    OMIM: 142995

    KEGG: hsa:3142

    STRING: 9606.ENSP00000355870

    UniGene: Hs.74870



主站蜘蛛池模板: 国产97色在线 | 免费| 久久久久成人片免费观看蜜芽| 日本边添边摸边做边爱的网站| 亚洲永久精品ww47| 无码人妻精品丰满熟妇区| 国产乱子伦一区二区三区四区五区 | 小辣椒福利视频导航| 午夜私人成年影院在线观看| 国产牛仔裤网站精品| 欧美精品videosex极品| 中文幕无线码中文字夫妻| 亚洲a综合一区二区三区| 色婷婷av一区二区三区浪潮| 精品熟女少妇av免费观看| 国产精品自在拍在线播放| 性国产牲交xxxxx视频| 国产精品亚洲专区无码破解版| 欧美偷窥清纯综合图区| 亚洲va中文字幕无码久久| 超薄丝袜足j好爽在线观看| 大肉大捧一进一出好爽视频mba| 99久久人妻无码精品系列| 永久免费的av在线电影网| 色天使久久综合给合久久97色 | 国产激情з∠视频一区二区| 99精品国产在热久久无码| 欧美日产国产新一区| 99国精品午夜福利视频不卡| 236宅宅理论片免费| 国产成人啪精品视频免费网站软件 | 樱桃视频影视在线观看免费| 精品无码一区二区三区爱欲九九| 亚洲成a人v在线蜜臀| av大尺度一区二区三区| 亚洲午夜福利在线观看| 永久黄网站免费视频性色| 人妻出轨av中文字幕| 狠狠噜天天噜日日噜视频跳一跳| 国产一区二区三区久久精品| 国产成人精品午夜福利在线观看| 日日摸日日碰夜夜爽无|