在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HIST1H1C (Ab-89) Antibody

  • 中文名稱:
    HIST1H1C (Ab-89)兔多克隆抗體
  • 貨號:
    CSB-PA010378OA89nforHU
  • 規格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA010378OA89nforHU diluted at 1:10 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HIST1H1C Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1), HIST1H1C, H1F2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from Human Histone H1.2 protein (82-94aa)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:10-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
  • 基因功能參考文獻:
    1. results define a network of E2F target genes as susceptible to the regulatory influence of H1.2, where H1.2 augments global association of pRb with chromatin, enhances transcriptional repression by pRb, and facilitates pRb-dependent cell-cycle arrest PMID: 28614707
    2. BRG1 participates in gene repression by interacting with H1.2, facilitating its deposition and stabilizing nucleosome positioning around the transcription start site. PMID: 27390128
    3. Results show that histones H1.2 and H1.4 were observed in MDA-MB-231 metastatic breast cancer cells. The phosphorylation at S173 of histone H1.2 and S172, S187, T18, T146, and T154 of H1.4 significantly increases during M phase suggesting that these events are cell cycle-dependent. Also, the study reports the observation of the H1.2 SNP variant A18V in MCF-10A cells. PMID: 26209608
    4. Integration with apoptotic intermediates (via C-terminal tail interactions) may constitute a more generalized function of linker histone isoforms in apoptotic cascades. PMID: 24525734
    5. Histone H1.2-T165 post translational modifications are dispensable for chromatin binding and cell proliferation while the H1.4-K26 modifications are essential for proper cell cycle progression. PMID: 24873882
    6. H1.2 interacts with Cul4A and PAF1 to activate developmental regulatory genes. PMID: 24360965
    7. H1.2 is less abundant than other histone H1 variants at the transcription start sites of inactive genes, and promoters enriched in H1.2 are different from those enriched in other histone H1 variants and tend to be repressed. PMID: 24476918
    8. Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma. PMID: 24435047
    9. These data suggest that p53 acetylation-H1.2 phosphorylation cascade serves as a unique mechanism for triggering p53-dependent DNA damage response pathways. PMID: 22249259
    10. confirmed N-terminal acetylation on all isoforms plus a single internal acetylation site; phosphorylation sites were located on peptides containing the cyclin dependent kinase (CDK) consensus motif PMID: 15595731
    11. The binding of histone H1 to a general amyloid-like motif indicates that histone H1 may play an important common role in diseases associated with amyloid-like fibrils. PMID: 16854430
    12. Histone H1.2 was translocated from the nucleus to the mitochondria after treatment with bleomycin and co-localized with Bak in mitochondria. PMID: 17879944
    13. that the recruitment of YB1, PURalpha, and H1.2 to the p53 target gene Bax is required for repression of p53-induced transcription. PMID: 18258596

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.
  • 蛋白家族:
    Histone H1/H5 family
  • 數據庫鏈接:

    HGNC: 4716

    OMIM: 142710

    KEGG: hsa:3006

    STRING: 9606.ENSP00000339566

    UniGene: Hs.7644



主站蜘蛛池模板: 亚洲熟妇av一区二区三区宅男| 激情欧美日韩一区二区| 午夜福利体验免费体验区| 国产在线无码视频一区二区三区| 涩涩鲁亚洲精品一区二区| 再深点灬舒服灬太大了网站| 国产韩国精品一区二区三区久久| 国产免费无码一区二区视频| 亚洲夜色噜噜av在线观看| 无码av中文一区二区三区| 国产三级在线观看播放视频| 欧美三根一起进三p| 在线看片免费人成视频久网| 欧美不卡无线在线一二三区观| 中文字幕在线精品视频入口一区 | 国产精品无码dvd在线观看| 两个人看的www视频免费完整版| 亚洲国产精品久久久久婷蜜芽 | 国产精品亚洲二区在线看| 亚洲裸男自慰gv网站 | 337p西西人体大胆瓣开下部| 国内熟女啪啪自拍| 亚洲精品无码av人在线观看国产| 丰满人妻被黑人连续中出| 成年性午夜免费视频网站| 精品无码久久久久久国产| 国产熟妇另类久久久久久| 久久99久久99久久综合| 人妻巨大乳hd免费看| 日韩中文字幕免费视频| 国产亚洲精品久久久久久小舞| av无码动漫一区二区三区精品 | 女人被强╳到高潮喷水在线观看| 18精品久久久无码午夜福利| 亚洲欧洲日本无在线码| 欧美日韩国产中文高清视频 | 在线观看特色大片免费网站| 三上悠亚精品一区二区久久 | 国产高清乱理伦片中文小说| 老妇女性较大毛片| 国产精品无码专区久久久|