在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HIST1H1C (Ab-109) Antibody

HIST1H1C (Ab-109) Antibody

  • 中文名稱：
    HIST1H1C (Ab-109)兔多克隆抗體
  • 貨號：
    CSB-PA010378PA109nforHU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA010378PA109nforHU diluted at 1:20 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA010378PA109nforHU diluted at 1:20 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HIST1H1C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1), HIST1H1C, H1F2
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from Human Histone H1.2 protein (100-112aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:10-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
  • 基因功能參考文獻：
    1. results define a network of E2F target genes as susceptible to the regulatory influence of H1.2, where H1.2 augments global association of pRb with chromatin, enhances transcriptional repression by pRb, and facilitates pRb-dependent cell-cycle arrest PMID: 28614707
    2. BRG1 participates in gene repression by interacting with H1.2, facilitating its deposition and stabilizing nucleosome positioning around the transcription start site. PMID: 27390128
    3. Results show that histones H1.2 and H1.4 were observed in MDA-MB-231 metastatic breast cancer cells. The phosphorylation at S173 of histone H1.2 and S172, S187, T18, T146, and T154 of H1.4 significantly increases during M phase suggesting that these events are cell cycle-dependent. Also, the study reports the observation of the H1.2 SNP variant A18V in MCF-10A cells. PMID: 26209608
    4. Integration with apoptotic intermediates (via C-terminal tail interactions) may constitute a more generalized function of linker histone isoforms in apoptotic cascades. PMID: 24525734
    5. Histone H1.2-T165 post translational modifications are dispensable for chromatin binding and cell proliferation while the H1.4-K26 modifications are essential for proper cell cycle progression. PMID: 24873882
    6. H1.2 interacts with Cul4A and PAF1 to activate developmental regulatory genes. PMID: 24360965
    7. H1.2 is less abundant than other histone H1 variants at the transcription start sites of inactive genes, and promoters enriched in H1.2 are different from those enriched in other histone H1 variants and tend to be repressed. PMID: 24476918
    8. Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma. PMID: 24435047
    9. These data suggest that p53 acetylation-H1.2 phosphorylation cascade serves as a unique mechanism for triggering p53-dependent DNA damage response pathways. PMID: 22249259
    10. confirmed N-terminal acetylation on all isoforms plus a single internal acetylation site; phosphorylation sites were located on peptides containing the cyclin dependent kinase (CDK) consensus motif PMID: 15595731
    11. The binding of histone H1 to a general amyloid-like motif indicates that histone H1 may play an important common role in diseases associated with amyloid-like fibrils. PMID: 16854430
    12. Histone H1.2 was translocated from the nucleus to the mitochondria after treatment with bleomycin and co-localized with Bak in mitochondria. PMID: 17879944
    13. that the recruitment of YB1, PURalpha, and H1.2 to the p53 target gene Bax is required for repression of p53-induced transcription. PMID: 18258596

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.
  • 蛋白家族：
    Histone H1/H5 family
  • 數據庫鏈接：

    HGNC: 4716

    OMIM: 142710

    KEGG: hsa:3006

    STRING: 9606.ENSP00000339566

    UniGene: Hs.7644



主站蜘蛛池模板： 亚洲熟妇久久国产精品| 中文亚洲欧美日韩无线码| 欧美精品高清在线观看| 风流少妇按摩来高潮| 伊人色综合网一区二区三区| 爆乳高潮喷水无码正在播放| 中文字幕亚洲一区二区三区| 日本丰满熟妇videossex8k| 日本丰满熟妇videossex一| 老师黑色丝袜被躁翻了av| 中文字幕av无码免费久久| 人妻va精品va欧美va| 无码国产精品一区二区免费式芒果| 久久精品免视看国产成人明星| 偷窥村妇洗澡毛毛多| 131美女爱做视频国产福利| 国产精品一久久香蕉国产线看观看| 精品黑人一区二区三区| 色综合天天综合高清网国产在线 | 国产极品粉嫩馒头一线天av| 亚洲丁香婷婷综合久久| 男女啪啪网站大全免费| 精品熟女日韩中文十区| 强行交换配乱婬bd| 两性色午夜视频免费老司机| 高潮迭起av乳颜射后入| 久久综合亚洲色hezyo社区| 亚洲精品一区二区三区在线观看| 久久er99国产精品免费| 日本又黄又爽gif动态图| 日日噜噜夜夜爽爽| 免费观看的av在线播放| 日韩av无码一区二区三区无码| 国产成人无码精品亚洲| 中文字幕一区二区人妻| 国产第一页浮力影院入口| 最大胆裸体人体牲交免费| 手机福利视频| 久久精品国产曰本波多野结衣| 无遮挡男女激烈动态图| 露脸叫床粗话东北少妇|