在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HIST1H1C (Ab-109) Antibody

HIST1H1C (Ab-109) Antibody

  • 中文名稱：
    HIST1H1C (Ab-109)兔多克隆抗體
  • 貨號：
    CSB-PA010378PA109nforHU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA010378PA109nforHU diluted at 1:20 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA010378PA109nforHU diluted at 1:20 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HIST1H1C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1), HIST1H1C, H1F2
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from Human Histone H1.2 protein (100-112aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:10-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
  • 基因功能參考文獻：
    1. results define a network of E2F target genes as susceptible to the regulatory influence of H1.2, where H1.2 augments global association of pRb with chromatin, enhances transcriptional repression by pRb, and facilitates pRb-dependent cell-cycle arrest PMID: 28614707
    2. BRG1 participates in gene repression by interacting with H1.2, facilitating its deposition and stabilizing nucleosome positioning around the transcription start site. PMID: 27390128
    3. Results show that histones H1.2 and H1.4 were observed in MDA-MB-231 metastatic breast cancer cells. The phosphorylation at S173 of histone H1.2 and S172, S187, T18, T146, and T154 of H1.4 significantly increases during M phase suggesting that these events are cell cycle-dependent. Also, the study reports the observation of the H1.2 SNP variant A18V in MCF-10A cells. PMID: 26209608
    4. Integration with apoptotic intermediates (via C-terminal tail interactions) may constitute a more generalized function of linker histone isoforms in apoptotic cascades. PMID: 24525734
    5. Histone H1.2-T165 post translational modifications are dispensable for chromatin binding and cell proliferation while the H1.4-K26 modifications are essential for proper cell cycle progression. PMID: 24873882
    6. H1.2 interacts with Cul4A and PAF1 to activate developmental regulatory genes. PMID: 24360965
    7. H1.2 is less abundant than other histone H1 variants at the transcription start sites of inactive genes, and promoters enriched in H1.2 are different from those enriched in other histone H1 variants and tend to be repressed. PMID: 24476918
    8. Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma. PMID: 24435047
    9. These data suggest that p53 acetylation-H1.2 phosphorylation cascade serves as a unique mechanism for triggering p53-dependent DNA damage response pathways. PMID: 22249259
    10. confirmed N-terminal acetylation on all isoforms plus a single internal acetylation site; phosphorylation sites were located on peptides containing the cyclin dependent kinase (CDK) consensus motif PMID: 15595731
    11. The binding of histone H1 to a general amyloid-like motif indicates that histone H1 may play an important common role in diseases associated with amyloid-like fibrils. PMID: 16854430
    12. Histone H1.2 was translocated from the nucleus to the mitochondria after treatment with bleomycin and co-localized with Bak in mitochondria. PMID: 17879944
    13. that the recruitment of YB1, PURalpha, and H1.2 to the p53 target gene Bax is required for repression of p53-induced transcription. PMID: 18258596

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.
  • 蛋白家族：
    Histone H1/H5 family
  • 數據庫鏈接：

    HGNC: 4716

    OMIM: 142710

    KEGG: hsa:3006

    STRING: 9606.ENSP00000339566

    UniGene: Hs.7644



主站蜘蛛池模板： 精品亚洲aⅴ在线无码播放| 在线观看特色大片免费网站| 久久精品亚洲日本波多野结衣 | 国产av一区二区精品凹凸| 亚洲精品综合欧美一区二区三区 | 加勒比久久综合网天天| 国产精品久久久久野外| 欧美又粗又大又硬又长又爽视频| 国产又色又爽又黄的视频在线观看| 国产精品午夜小视频观看| 亚洲欧美精品aaaaaa片| 久久成人国产精品免费| 大胸美女污污污www网站| 久久精品噜噜噜成人av| 人妻夜夜爽天天爽三区| 日本www一道久久久免费| 性一交一乱一伦一| 久青青视频在线观看久| 狠狠综合久久久久尤物丿| 98色婷婷在线| 在线无码av一区二区三区| 日韩a∨精品日韩在线观看| 老熟女毛茸茸浓毛| 蜜桃av久久久一区二区三区麻豆 | 亚洲综合网站久久久| 毛片免费视频在线观看| 精品久久久久久国产| 免费国产h视频在线观看| 国产农村乱辈无码| 国产精品熟妇一区二区三区四区| 久久久无码精品亚洲日韩蜜桃| 国产蜜芽尤物在线一区| 欧美 亚洲 日韩 中文2019 | 日本妇人成熟免费| 亚洲欧美日韩视频高清专区| 女人19水真多免费毛片| 欧美人与动牲交a精品| 国产超碰人人爱被ios解锁| 一区二区在线 | 国| 制服丝袜中文字幕在线| 无码人妻精品中文字幕|