在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HELLS Antibody

HELLS Antibody

  • 中文名稱：
    HELLS兔多克隆抗體
  • 貨號：
    CSB-PA010280GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    HELLS
  • 別名：
    FLJ10339 antibody; Helicase lymphoid specific antibody; Hells antibody; HELLS_HUMAN antibody; LSH antibody; Lymphoid specific helicase antibody; Lymphoid-specific helicase antibody; Nbla10143 antibody; PASG antibody; Proliferation associated SNF2 like protein antibody; Proliferation-associated SNF2-like protein antibody; SWI/SNF2 related matrix associated actin dependent regulator of chromatin subfamily A member 6 antibody; SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human HELLS
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.
  • 基因功能參考文獻：
    1. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex; immunodeficiency-centromeric instability-facial anomalies syndrome has a defective HELLS and CDCA7 bipartite nucleosome remodeling complex PMID: 29339483
    2. This study elucidates the molecular basis of the c-Myc/EGLN1-mediated induction of LSH expression that inhibits ferroptosis PMID: 28900510
    3. LSH is likely one of the mechanisms of genome instability underlying 5-hydroxymethylcytosine loss in cancer. PMID: 29109788
    4. High mRNA levels of HELLS is independent predictor of poor outcome in Renal Cell Carcinoma patients. PMID: 28069330
    5. Mutations in HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome type 4. PMID: 26216346
    6. Mutations of HELLS gene is associated with stomach and colorectal cancers. PMID: 25351940
    7. Upregulation of HELLS and UHRF1 is essential for the tumor phenotype. Also, these epigenetic regulators are important for the regulation of SYK. PMID: 25338120
    8. just as E2F3, HELLS is overexpressed in human tumours including prostate cancer, indicating that either factor may contribute to the malignant progression of tumours PMID: 22157815
    9. E2F1 plays a crucial role in transcriptional control of the human Lsh gene and the decrease of Lsh expression in senescent cells is related to the repression of E2F1 PMID: 21453717
    10. Data provide strong evidence that CEP55 and HELLS may be used in conjunction with FOXM1 as a biomarker set for early cancer detection and indicators of malignant conversion and progression. PMID: 20400365
    11. LSH serves as a recruiting factor for DNA methyltransferases and histone deacetylases to establish transcriptionally repressive chromatin which is perhaps further stabilized by DNA methylation at targeted loci PMID: 17967891
    12. These results suggest differences in cellular consequences of hypomethylation mediated by PASG during development compared to that in somatic cells. PMID: 18948754
    13. Lsh overexpression delays cell senescence by silencing p16(INK4a) in human fibroblasts. PMID: 19561196

    顯示更多

    收起更多

  • 相關疾病：
    Immunodeficiency-centromeric instability-facial anomalies syndrome 4 (ICF4)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 組織特異性：
    Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloi
  • 數據庫鏈接：

    HGNC: 4861

    OMIM: 603946

    KEGG: hsa:3070

    STRING: 9606.ENSP00000239027

    UniGene: Hs.463677



主站蜘蛛池模板： 精品免费国偷自产在线视频| 亚洲高清国产拍精品网络战| 亚洲乱亚洲乱妇| 无码手机线免费观看| 久久视热这里只有精品| 国产人妻久久精品二区三区老狼| 国产精品久久久久久久久久久久 | 国产亚洲精品久久久美女18黄| 日本黄漫动漫在线观看视频 | 怡红院av亚洲一区二区三区h| 亚洲国产精品久久久久秋霞影院| 亚洲欧美日韩中文无线码| 在教室伦流澡到高潮hgl动漫| 国产v在线最新观看视频| 国产成人午夜精华液 | 国产精品日本亚洲777| av无码免费一区二区三区| 亂倫近親相姦中文字幕| 色妞精品av一区二区三区| 国产日韩精品视频无码| 国产丝袜美女| 荡女精品导航| 国产成人 综合 亚洲欧洲| 亚洲国产av无码综合原创国产| 亚洲精品久久久久久中文| 综合 欧美 亚洲日本| 精品无码一区二区三区电影| 欧美最猛性xxxxx大叫| 久久久久国色av免费观看性色| 精品国产欧美一区二区| 秋霞国产成人精品午夜视频app| 天堂网在线www资源| 92国产精品午夜福利免费| 国产精品亚洲专区无码web| 欧美片内射欧美美美妇| 无码少妇一区二区浪潮av| 国产精品久线在线观看| 亚洲精品国产精品乱码不卡| 久久亚洲色www成人男男| 久久久国产精品黄毛片| 亚洲国产一区二区三区|