在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HELLS Antibody

  • 中文名稱:
    HELLS兔多克隆抗體
  • 貨號:
    CSB-PA010280GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HELLS
  • 別名:
    FLJ10339 antibody; Helicase lymphoid specific antibody; Hells antibody; HELLS_HUMAN antibody; LSH antibody; Lymphoid specific helicase antibody; Lymphoid-specific helicase antibody; Nbla10143 antibody; PASG antibody; Proliferation associated SNF2 like protein antibody; Proliferation-associated SNF2-like protein antibody; SWI/SNF2 related matrix associated actin dependent regulator of chromatin subfamily A member 6 antibody; SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human HELLS
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.
  • 基因功能參考文獻:
    1. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex; immunodeficiency-centromeric instability-facial anomalies syndrome has a defective HELLS and CDCA7 bipartite nucleosome remodeling complex PMID: 29339483
    2. This study elucidates the molecular basis of the c-Myc/EGLN1-mediated induction of LSH expression that inhibits ferroptosis PMID: 28900510
    3. LSH is likely one of the mechanisms of genome instability underlying 5-hydroxymethylcytosine loss in cancer. PMID: 29109788
    4. High mRNA levels of HELLS is independent predictor of poor outcome in Renal Cell Carcinoma patients. PMID: 28069330
    5. Mutations in HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome type 4. PMID: 26216346
    6. Mutations of HELLS gene is associated with stomach and colorectal cancers. PMID: 25351940
    7. Upregulation of HELLS and UHRF1 is essential for the tumor phenotype. Also, these epigenetic regulators are important for the regulation of SYK. PMID: 25338120
    8. just as E2F3, HELLS is overexpressed in human tumours including prostate cancer, indicating that either factor may contribute to the malignant progression of tumours PMID: 22157815
    9. E2F1 plays a crucial role in transcriptional control of the human Lsh gene and the decrease of Lsh expression in senescent cells is related to the repression of E2F1 PMID: 21453717
    10. Data provide strong evidence that CEP55 and HELLS may be used in conjunction with FOXM1 as a biomarker set for early cancer detection and indicators of malignant conversion and progression. PMID: 20400365
    11. LSH serves as a recruiting factor for DNA methyltransferases and histone deacetylases to establish transcriptionally repressive chromatin which is perhaps further stabilized by DNA methylation at targeted loci PMID: 17967891
    12. These results suggest differences in cellular consequences of hypomethylation mediated by PASG during development compared to that in somatic cells. PMID: 18948754
    13. Lsh overexpression delays cell senescence by silencing p16(INK4a) in human fibroblasts. PMID: 19561196

    顯示更多

    收起更多

  • 相關疾病:
    Immunodeficiency-centromeric instability-facial anomalies syndrome 4 (ICF4)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    SNF2/RAD54 helicase family
  • 組織特異性:
    Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloi
  • 數據庫鏈接:

    HGNC: 4861

    OMIM: 603946

    KEGG: hsa:3070

    STRING: 9606.ENSP00000239027

    UniGene: Hs.463677



主站蜘蛛池模板: 国产寡妇偷人在线观看| 波多野结衣中文字幕一区二区三区| 卡一卡二卡三免费视频| 亚洲a∨国产av综合av| 亚洲337少妇裸体艺术| 亚洲国产成人精品无码区花野真一 | 国产99视频精品免费视频36| 久久人人爽人人爽爽久久小说| 亚洲精品久久午夜麻豆| 国产又粗又猛又爽又黄| 国产69精品久久久久999小说| 久久精品中文騷妇女内射| 夜夜春亚洲嫩草影院| 国产精品爽爽va吃奶在线观看 | av无码精品一区二区三区宅噜噜| 中文天堂在线www最新版官网| 中文字幕日韩人妻不卡一区| 露脸叫床粗话东北少妇| 成年女性特黄午夜视频免费看| 无人区码一码二码w358cc| 免费国产在线精品一区不卡 | 国产成人无码午夜视频在线播放 | 中文字幕中文乱码www| 女人高潮被爽到呻吟在线观看| 久久午夜夜伦鲁鲁片免费无码影视 | 无码ol丝袜高跟秘书在线观看| 国产精品自在拍首页视频8| 亚洲熟女www一区二区三区| 长腿校花无力呻吟娇喘| 国产精品美脚玉足脚交| 亚洲国产精品无码久久sm| 玩弄人妻少妇500系列| 都市激情 在线 亚洲 国产| 久久69精品久久久久久hb| 就去干成人网| 少妇久久久久久被弄到高潮| 强被迫伦姧惨叫人妻系列| 国语少妇高潮对白在线| 国产国产乱老熟女视频网站97 | 免费无码又爽又刺激激情视频软件| 自拍偷自拍亚洲精品被多人伦好爽|