在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HELLS Antibody

HELLS Antibody

  • 中文名稱：
    HELLS兔多克隆抗體
  • 貨號：
    CSB-PA010280GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    HELLS
  • 別名：
    FLJ10339 antibody; Helicase lymphoid specific antibody; Hells antibody; HELLS_HUMAN antibody; LSH antibody; Lymphoid specific helicase antibody; Lymphoid-specific helicase antibody; Nbla10143 antibody; PASG antibody; Proliferation associated SNF2 like protein antibody; Proliferation-associated SNF2-like protein antibody; SWI/SNF2 related matrix associated actin dependent regulator of chromatin subfamily A member 6 antibody; SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human HELLS
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.
  • 基因功能參考文獻：
    1. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex; immunodeficiency-centromeric instability-facial anomalies syndrome has a defective HELLS and CDCA7 bipartite nucleosome remodeling complex PMID: 29339483
    2. This study elucidates the molecular basis of the c-Myc/EGLN1-mediated induction of LSH expression that inhibits ferroptosis PMID: 28900510
    3. LSH is likely one of the mechanisms of genome instability underlying 5-hydroxymethylcytosine loss in cancer. PMID: 29109788
    4. High mRNA levels of HELLS is independent predictor of poor outcome in Renal Cell Carcinoma patients. PMID: 28069330
    5. Mutations in HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome type 4. PMID: 26216346
    6. Mutations of HELLS gene is associated with stomach and colorectal cancers. PMID: 25351940
    7. Upregulation of HELLS and UHRF1 is essential for the tumor phenotype. Also, these epigenetic regulators are important for the regulation of SYK. PMID: 25338120
    8. just as E2F3, HELLS is overexpressed in human tumours including prostate cancer, indicating that either factor may contribute to the malignant progression of tumours PMID: 22157815
    9. E2F1 plays a crucial role in transcriptional control of the human Lsh gene and the decrease of Lsh expression in senescent cells is related to the repression of E2F1 PMID: 21453717
    10. Data provide strong evidence that CEP55 and HELLS may be used in conjunction with FOXM1 as a biomarker set for early cancer detection and indicators of malignant conversion and progression. PMID: 20400365
    11. LSH serves as a recruiting factor for DNA methyltransferases and histone deacetylases to establish transcriptionally repressive chromatin which is perhaps further stabilized by DNA methylation at targeted loci PMID: 17967891
    12. These results suggest differences in cellular consequences of hypomethylation mediated by PASG during development compared to that in somatic cells. PMID: 18948754
    13. Lsh overexpression delays cell senescence by silencing p16(INK4a) in human fibroblasts. PMID: 19561196

    顯示更多

    收起更多

  • 相關疾病：
    Immunodeficiency-centromeric instability-facial anomalies syndrome 4 (ICF4)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 組織特異性：
    Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloi
  • 數據庫鏈接：

    HGNC: 4861

    OMIM: 603946

    KEGG: hsa:3070

    STRING: 9606.ENSP00000239027

    UniGene: Hs.463677



主站蜘蛛池模板： 国产女人水真多18毛片18精品| av影音先锋最大资源网| 日本无遮挡吸乳呻吟视频| 久久成人国产精品| 国产无套内射普通话对白| 久久国产成人免费网站777| 成在人线av无码免费看网站直播| 亚洲中文字幕无码久久| 韩国理伦片一区二区三区在线播放| 在线视频精品免费观看10| 欧美特黄特色三级视频在线观看| 亚洲 欧美 日韩 综合aⅴ视频| 无码成人aaaaa毛片| 国产成人免费无码av在线播放| 中文字幕v亚洲日本在线电影| 亚洲熟妇丰满大屁股熟妇| 99久久无码私人网站| 日韩欧无码一二三区免费不卡| 好男人在在线社区www在线影院| 中字幕视频在线永久在线观看免费| 手机看片福利一区二区三区| 青青草国产精品欧美成人| 亚洲图片综合图区20p| 高潮毛片无遮挡高清免费| 亚洲aⅴ综合色区无码一区| 色欲天天天天天综合网| 国产欧美精品区一区二区三区| 日本欧美大码a在线观看| 无码动漫性爽xo视频在线观看 | 制服视频在线一区二区| 欧美大波少妇在厨房被| 国产精品视频永久免费播放| 黑人巨大跨种族video| 中日精品无码一本二本三本 | 人妻无码一区二区三区| 日产亚洲一区二区三区| 久久人午夜亚洲精品无码区| 少妇人妻丰满做爰xxx| 精国产品一区二区三区a片| 久久国产午夜精品理论片| 国产又黄又大又粗视频|