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HECTD3 Antibody

  • 中文名稱:
    HECTD3兔多克隆抗體
  • 貨號:
    CSB-PA725567LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunofluorescence staining of A549 cells with CSB-PA725567LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HECTD3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    HECTD3
  • 別名:
    E3 ubiquitin-protein ligase HECTD3 antibody; HECD3_HUMAN antibody; HECT antibody; HECT domain containing protein 3 antibody; HECT domain-containing protein 3 antibody; HECTD3 antibody; Probable E3 ubiquitin protein ligase HECTD3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human E3 ubiquitin-protein ligase HECTD3 protein (682-785AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,HECTD3 Antibody (CSB-PA725567LA01HU),的標記方式是Non-conjugated。對于HECTD3 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA725567LB01HU HECTD3 Antibody, HRP conjugated ELISA
    FITC CSB-PA725567LC01HU HECTD3 Antibody, FITC conjugated
    Biotin CSB-PA725567LD01HU HECTD3 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8.
  • 基因功能參考文獻:
    1. HECTD3 as a tumor suppressor modulating the activity of this important oncogenic signaling pathway. PMID: 28636940
    2. Overexpression of MALT1 partially rescues HECTD3 depletion-induced apoptosis. PMID: 23358872
    3. All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara. PMID: 18194665
  • 亞細胞定位:
    Cytoplasm, perinuclear region.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 26117

    KEGG: hsa:79654

    STRING: 9606.ENSP00000361245

    UniGene: Hs.525084



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