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  4. HECTD3 Antibody, FITC conjugated

HECTD3 Antibody, FITC conjugated

  • 中文名稱：
    HECTD3兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA725567LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HECTD3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HECTD3
  • 別名：
    E3 ubiquitin-protein ligase HECTD3 antibody; HECD3_HUMAN antibody; HECT antibody; HECT domain containing protein 3 antibody; HECT domain-containing protein 3 antibody; HECTD3 antibody; Probable E3 ubiquitin protein ligase HECTD3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase HECTD3 protein (682-785AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8.
  • 基因功能參考文獻：
    1. HECTD3 as a tumor suppressor modulating the activity of this important oncogenic signaling pathway. PMID: 28636940
    2. Overexpression of MALT1 partially rescues HECTD3 depletion-induced apoptosis. PMID: 23358872
    3. All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara. PMID: 18194665
  • 亞細胞定位：
    Cytoplasm, perinuclear region.
  • 數據庫鏈接：

    HGNC: 26117

    KEGG: hsa:79654

    STRING: 9606.ENSP00000361245

    UniGene: Hs.525084



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