在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HDC Antibody

  • 中文名稱:
    HDC兔多克隆抗體
  • 貨號:
    CSB-PA067502
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA067502(HDC Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA067502(HDC Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    HDC
  • 別名:
    DCHS_HUMAN antibody; EC 4.1.1.22 antibody; HDC antibody; Histidine decarboxylase antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human HDC
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:15-1:50
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Catalyzes the biosynthesis of histamine from histidine.
  • 基因功能參考文獻(xiàn):
    1. Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. This review summarizes the analogies and differences in their origin as well as their common pathophysiological scenarios. [review] PMID: 27769832
    2. a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population PMID: 27529419
    3. Human enterochromaffin-like cells appear to partially co-express VMAT-2 and HDC. Co-expression of VMAT-2 and HDC might be required for increased histamine production in patients with gastric neuroendocrine tumors. PMID: 26715806
    4. The findings indicate that polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer. PMID: 24835231
    5. HDC rs17740607 polymorphism is at least a partial loss-of-function variant and acts as a protective factor against chronic heart failure PMID: 25846768
    6. Investigated variation across the HDC (histidine decarboxylase) gene for association with Tourette Syndrome. PMID: 23825391
    7. HDC production in the stomach is associated with bile acid exposure and its related transcriptional regulation network of FXR, SHP, and CDX1. PMID: 24415870
    8. Data indicate that histidine decarboxylase (HDC) is expressed by neutrophils. PMID: 23572231
    9. Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase. PMID: 22767596
    10. crystal of histidine decarboxylase belonged to space group C2, with unit-cell parameters a = 215.16, b = 112.72, c = 171.39 A, beta = 110.3 degrees PMID: 22684068
    11. It was shown that for serum and urine, HDC levels achieved sensitivities and specificities compatible to or even greater than those of established biomarkers for the diagnosis of intestinal mucosal injury in patients with acute intestinal obstruction. PMID: 21915437
    12. The novel concept that an autocrine loop, consisting of enhanced histamine synthesis by histidine decarboxylase, sustains cholangiocarcinoma growth is proposed. PMID: 21873469
    13. Variants in the HDC gene may play little or no role in Tourette Syndrome susceptibility in Chinese Han population. PMID: 22095709
    14. Studies provide lead compounds for inhibitors of ornithine decarboxylase and human histidine decarboxylase. PMID: 21454364
    15. The histidine decarboxylase allele Glu644 in homozygosity increases the risk of developing rhinitis in the studied population PMID: 20608921
    16. identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis which points to its role in Tourette's syndrome and tics PMID: 20445167
    17. the elevation of HDC expression during human monocytic differentiation PMID: 11556524
    18. HDC expression is regulated by gastrin through a complex cis-acting element, which binds at least three distinct nuclear factors PMID: 12372397
    19. Histidine decarboxylase promoter activity can be repressed by kruppel-like factor 4 PMID: 14670968
    20. histidine decarboxylase mRNA is found in human vascular smooth muscle and endothelial cells PMID: 15167966
    21. HDC and histamine content were significantly higher in the tumor specimens PMID: 15928846
    22. Chronic urticaria expresses high levels of HDC as compared to normal foreskin, breast skin and cultured human keratinocytes. PMID: 16297195
    23. HDC expression and histamine production are increased in the superficial kidney cortex zone during pregnancy PMID: 16760908
    24. Defective levels found in normal placenta compared with pre-eclampsia labor. PMID: 16822545
    25. Synthesis of histamine was found to be restricted to the basophil compartment of the CML clone and to depend on signaling through the PI3-kinase pathway. CML cells also expressed histamine receptors PMID: 16849647
    26. HDC SNP's are significantly associated with age at natural menopause in Caucasian women. PMID: 16919600
    27. Histamine decarboxylase expressed in endothelial cells of microvessels might play a role in regulating angiogenesis in esophageal squamous cell carcinomas. PMID: 19133005
    28. HFR was regulated by HIF-1 activation. Depletion of HIF-1alpha prevents hypoxic induction of HDC in BMMCs. Hypoxia induces HDC expression by transcriptional mechanisms dependent upon HIF-1. PMID: 19266161
    29. the apparent occurrence of an unusual TG 3' splice site in intron 4 is discussed PMID: 17672918

    顯示更多

    收起更多

  • 蛋白家族:
    Group II decarboxylase family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4855

    OMIM: 142704

    KEGG: hsa:3067

    STRING: 9606.ENSP00000267845

    UniGene: Hs.1481



主站蜘蛛池模板: 中文字幕制服丝袜第57页| 8x福利精品第一导航| 成年网站未满十八禁视频天堂| 中文午夜人妻无码看片| 国产极品粉嫩福利姬萌白酱| 久久久久噜噜噜亚洲熟女综合| 曰本极品少妇videossexhd| 无码人妻在线一区二区三区免费 | 女高中生第一次破苞av| 久久综合给合久久97色| 2021国产精品自在自线| 超碰色偷偷男人的天堂| 女人高潮抽搐潮喷小视频| 国产亚洲精品资源在线26u| 亚洲成av人片香蕉片| 狠狠躁夜夜躁人人爽天天不卡| 免费视频爱爱太爽了激情| 色伦专区97中文字幕| 少妇激情一区二区三区视频 | 国精产品一区二区三区有限公司| 最新亚洲春色av无码专区| 亚洲精品制服丝袜四区| 亚洲 欧美 动漫 少妇 自拍| 精品久久久无码中文字幕| 男人扒开添女人下部免费视频| 国产在线无码一区二区三区| 天堂av成年av影视| 国产人妻一区二区三区久| 日韩理论午夜无码| 亚洲一区二区三区波多野结衣| 国产免费极品av吧在线观看| 爆乳熟妇一区二区三区霸乳| 黑人狠狠的挺身进入| 五十路熟妇强烈无码| 久久国产中文娱乐网| √最新版天堂资源在线| 亚洲精品无码久久久久av老牛| 国产无遮挡又黄又爽不要vip软件| 国产精品自产拍高潮在线观看 | 亚洲高清成人av电影网站| 无码喷水一区二区浪潮av|