在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HCRTR1 Antibody

  • 中文名稱:
    HCRTR1兔多克隆抗體
  • 貨號:
    CSB-PA797469
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA797469(HCRTR1 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA797469(HCRTR1 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    HCRTR1; Orexin/Hypocretin receptor type 1; Hypocretin receptor type 1; Orexin receptor type 1; Ox-1-R; Ox1-R; Ox1R
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human HCRTR1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
  • 基因功能參考文獻:
    1. Study provides the first demonstration that OX1R is aberrantly expressed in the inflamed mucosa of ulcerative colitis patients, both in the epithelial and immune cells. PMID: 30251681
    2. In this study we demonstrate a new role of MRAP2 in the regulation of the orexin receptor 1 (OX1R) and identify the specific regions of MRAP2 required for the regulation of OX1R and PKR1. Importantly, like MC4R and PKRs, OX1R is predominately expressed in the brain where it regulates food intake PMID: 28939058
    3. After sequencing all orexin receptor exons, one variation (rs2271933) in the OX1R gene and one variation (rs2653349) in the OX2R gene were found. However, no significant differences were found in either genotypic or allelic frequency distributions between the two study groups PMID: 27988352
    4. G-protein-dependency of OX1 receptor signalling PMID: 27237973
    5. Several single nucleotide polymorphisms (SNPs) in HCRTR2 were nominally associated with Antipsychotic-induced weight gain (AIWG) in patients of European ancestry treated with either clozapine or olanzapine. None of the SNPs in HCRTR1 were associated with AIWG. PMID: 26447462
    6. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the HCRTR1 gene. PMID: 26555080
    7. This study determined structures of OX1R bound to the OX1R-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution. PMID: 26950369
    8. the orexinA/OX1 receptor axis has a significant pro-survival function in adrenal cells. PMID: 26459696
    9. OX1R signaling can attenuate KOR-mediated reduction of cellular cAMP levels while enhancing KOR-mediated beta-arrestin recruitment and p38 activation. PMID: 25857454
    10. OX1R and KOR heterodimerize, and this heterodimer associates with Galphas, leading to increased protein kinase A (PKA) signaling pathway activity, including upregulation of intracellular cAMP levels. PMID: 25866368
    11. No significant differences were found in the distribution of either genotypic or allelic frequencies between Alzheimer's disease cases and controls in the HCRTR1 polymorphisms. PMID: 24969517
    12. Orexins modifiy orexin receptor gene expression and gonadotropin release from the anterior pituitary gland. PMID: 24333629
    13. DQ B1 but not HLA-DR typing, TNF-alpha levels, HCRTR1 and HCRTR2 were higher in narcolepsy-cataplexy/schizophrenia patients. PMID: 24268496
    14. The present data indicate that OX1R-driven apoptosis is overexpressed in androgeno-independent prostate cancer exhibiting a neuroendocrine differentiation opening a gate for novel therapies for these aggressive cancers which are incurable until now. PMID: 24910418
    15. Both orexin receptor subtypes, OX1R and OX2R, and CB1 cannabinoid receptors are capable of forming constitutive homo- and heteromeric complexes. PMID: 24530395
    16. [review] Native orexin peptides consist of receptor agonists, orexin-A (33 amino acids) and orexin-B (28 amino acids) (aka hypocretin-1 and hypocretin-2). PMID: 23034387
    17. Orexin receptors generate potent endocannabinoid signals in addition to arachidonic acid signals, which may explain the proposed orexin-cannabinoid interactions. PMID: 22550093
    18. decreased ventilatory responses to hypoxia in human narcolepsy-cataplexy is in relation to HLA-DQB1*0602 status, not hypocretin deficiency PMID: 21318258
    19. Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. PMID: 22389503
    20. HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura; the hypocretin system may have a role in the pathophysiology of migraine. PMID: 21344296
    21. The Ile408Val polymorphism in the hypocretin receptor 1 (HCRTR1) gene and the Val308Iso (G1246A) polymorphism in the hypocretin receptor 2 (HCRTR2) gene in a sample of 215 panic disorder patients and 454 controls, were analyzed. PMID: 21666548
    22. Data show that the HCRTR1 gene or a linked locus may modulate the risk for Major Mood Disorders and supports recent studies suggesting an involvement of hypocretin neurotransmitter system in affective disorders. PMID: 21071097
    23. Results show that the N-terminal regions of orexin receptor are most important, and the exchange of the area from the C-terminal part of the transmembrane helix 2 to the transmembrane helix 4 is enough to lead to a change of the receptor's ligand profile. PMID: 21510948
    24. analysis of orexin receptor 1 and 2 -arrestin-ubiquitin complexes PMID: 21378163
    25. In differentiated IMR-32 neuroblastoma cells orexin/hypocretin and bradykinin receptors activate TRPC3/6 channels. PMID: 20728215
    26. Data demonstrate the functional role of protein kinase D1 and protein kinase D3 in modulating physiological responses to Ox1R activation. PMID: 20621130
    27. OX1 orexin receptor activation results in robust arachidonic acid release. PMID: 20002100
    28. It was shown here that another motif, immunoreceptor tyrosine-based switch motif, is present in orexin receptor-1 (OX1R) and is mandatory for OX1R-mediated apoptosis. PMID: 19661287
    29. The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor. PMID: 11856342
    30. evidence that CB1 is able to potentiate an orexigenic receptor, OX1R PMID: 12690115
    31. both OX1R and OX2R are expressed in the testis, epididymis, penis, and seminal vesicle PMID: 15070969
    32. OX(1) receptors stimulate adenylyl cyclase via a low potency G(s) coupling and a high potency phospholipase C --> PKC coupling. PMID: 15611118
    33. All adrenal corttex adenomas expressed OX1-R and OX2-R mRNAs, and real-time PCR showed that the expression of both receptors was up-regulated in adenomas PMID: 15797953
    34. Our preliminary data suggest that mutation hcrtr1 might have an increased susceptibility to polydipsia through an undetermined mechanism. PMID: 15978554
    35. Orexins act exclusively through OX1-receptors coupled to the adenylate cyclase/protein kinase A-dependent signaling cascade. PMID: 16157481
    36. OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase PMID: 16282319
    37. This is the first demonstration of loss of Hcrt/Orx neurons in MSA, which is consistent with a system degeneration of neurons involved in homeostatic function, including sleep and autonomic regulation, in this disorder. PMID: 17089135
    38. Results support the hypothesis that the HCRTR1 Ile408Val polymorphism may confer susceptibility to polydipsia in schizophrenia. PMID: 17999203
    39. orexin-induced apoptosis is driven by an immunoreceptor tyrosine-based inhibitory motif (ITIM) present in the OX1R and is mediated by SHP-2 phosphatase recruitment via a mechanism that requires Gq protein but is independent of phospholipase C activation. PMID: 18198212
    40. Both sporadic narcoleptic dogs and human narcolepsy-cataplexy subjects showed a significant decrease in hcrtR1 expression, while declines in hcrtR2 expression were not significant in these cases. PMID: 18714784
    41. Induction of intracellular calcium signaling in isolated duodenal enterocytes is mediated primarily by OX1R receptors PMID: 19118115
    42. OX1R are able to activate TRPC(3)-channel-dependent oscillatory responses independently of store discharge. PMID: 19464259

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數據庫鏈接:

    HGNC: 4848

    OMIM: 602392

    KEGG: hsa:3061

    STRING: 9606.ENSP00000362810

    UniGene: Hs.388226



主站蜘蛛池模板: 欧美与黑人午夜性猛交久久久 | 曰批全过程免费视频观看软件潮喷 | 中文字幕精品无码一区二区三区| 国产精品一区二区香蕉| 日韩免费无码视频一区二区三区 | 新版资源天堂中文| 国产精品免费观看调教网| 无码熟妇人妻av在线网站| 久久久日韩精品一区二区三区| 男女猛烈xx00免费视频试看| 日本55丰满熟妇厨房伦| 在线成人a毛片免费播放| 伊人伊成久久人综合网996| 国产婷婷综合在线视频| 丰满熟女人妻中文字幕免费| 亚洲日韩激情无码一区| 超级av在线天堂东京热| 中文字幕久久久久人妻| 亚洲国产精品无码久久一线| 中文字幕精品亚洲无线码二区| 国产熟睡乱子伦午夜视频| 免费人成网站在线观看不卡| 特黄大片又粗又大又暴| 国产精品亚洲第一区在线观看| 亚洲 激情 小说 另类 欧美| 国产精品久久久久久52avav| 亚洲aⅴ在线无码播放毛片一线天| 尤物永久网站| 亚洲综合色视频在线观看| 日日摸日日碰夜夜爽免费| 欧美高清freexxxx性| 中文字幕人乱码中文| 亚洲精品四区麻豆文化传媒| 久久精品网站免费观看| 2021亚洲国产成a在线| 97精品国产一区二区三区| 男女啪啪做爰高潮无遮挡| 久久人人爽人人爽爽久久小说| 精品国产天堂综合一区在线| 久久香蕉国产线看观看精品yw| 久久www成人_看片免费不卡|