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  4. H6PD Antibody, FITC conjugated

H6PD Antibody, FITC conjugated

  • 中文名稱：
    H6PD兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA010111LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) H6PD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    H6PD
  • 別名：
    GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363), 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)], H6PD, GDH
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human GDH/6PGL endoplasmic bifunctional protein (422-712aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway. May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate. The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum. By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity.
  • 基因功能參考文獻：
    1. Data indicate the tetramer as the most active form of glucose-6-phosphate dehydrogenase (G6PDH). PMID: 28370139
    2. cortisol reduces glucose-6-phosphate (G6P) flux through H6PDH by increasing luminal NADPH, thereby allowing more G6P for hydrolysis via G6Pase PMID: 26860459
    3. Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death. PMID: 26337086
    4. The G allele of rs6688832 in H6PD might exert potential genetic protective role against the development of PCOS, especially in overweight women. PCOS patients with AG genotype of rs6688832 might confer risk to the phenotype of hyperandrogenemia of PCOS. PMID: 26452272
    5. The aim of the work was to investigate the expression of HSD11B1, HSD11B2, H6PDH, and glucocorticoids receptor (GR) mRNA in subcutaneous adipose tissue (SAT) from obese women with or without polycystic ovary syndrome. PMID: 23979790
    6. Cytoplasmic Mg2+ regulates glucose 6-phosphate utilization by reticular H6PD. PMID: 24631573
    7. GR and p300 are involved in the induction of H6PD by cortisol in human amnion fibroblasts PMID: 23125313
    8. Polymorphisms in the H6PD gene may not be associated with type 2 diabetes and the metabolic syndrome. PMID: 21869537
    9. Antioxidant supplementation was noted to increase G6PDH in the pentose phosphate cycle and 18S rRNA in the ribosome. There were no significant changes in the gene expression levels of beta-ACT PMID: 22285204
    10. R453Q and D151A variants of the H6PD gene are associated with PCOS and obesity, respectively, and may contribute to the PCOS phenotype by influencing obesity, insulin resistance and hyperandrogenism. PMID: 22306327
    11. Results suggest a novel role for the H6PD gene in atherosclerosis susceptibility. PMID: 21858044
    12. the H6PD gene is very polymorphic and missense variants are common, coding variants rarely (<1.5%) are responsible for hyperandrogenemic polycystic ovary syndrome. PMID: 21050867
    13. identified a mitochondrial matrix-associated G6PDH and also provide evidence that metabolic state/glucose availability modulate enzymatic sources of NADPH PMID: 20228249
    14. This study corroborates the association of one locus determined by genome-wide association study and points to H6PD as a new candidate gene for multiple sclerosis. PMID: 19935835
    15. findings indicate that the decrease in G6PDH activity that occurs after exposure of lung epithelial cells to chrysotile results from the carbonylation of G6PDH by TBARS PMID: 20211231
    16. Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. PMID: 12858176
    17. H6PDH directly determines the reaction direction of 11beta-Hydroxysteroid dehydrogenase1 in intact cells as an oxoreductase. PMID: 15280030
    18. A new chemiluminescent method was applied to the determination of G6PDH in healthy and enzyme-deficient individuals. PMID: 15767211
    19. Two new missense mutations in glucose-6-phosphate dehydrogenase gene associated with chronic hemolytic anemia. PMID: 16079115
    20. Mutations found in beta thassemia patients complicated by liver disease. PMID: 16079116
    21. The observed constant expression of H6PD suggests that HSD11B1 acts as a reductase throughout the adipogenesis process in human ADMSCs and murine 3T3-L1 cells. PMID: 18586838
    22. Hepatic 11beta-HSD1 and H6PDH are closely interlinked. 11beta-HSD1 gene expression does not seem to be involved in the pathogenesis of fatty liver or nonalcoholic steatohepatitis. PMID: 18665910
    23. Data show that adipose tissue 11-beta-Hydroxysteroid Dehydrogenase Type 1 and Hexose-6-Phosphate Dehydrogenase gene expressions are increased in patients with type 2 diabetes mellitus. PMID: 18963204
    24. The impact of H6PDH on the modulation of 11beta-HSD1-dependent interconversion of cortisone and cortisol by inhibitors and alternative substrates, was investigated. PMID: 19010388
    25. Using co-immunoprecipitation experiments with purified H6PDH and 11beta-HSD1, and with cell lysates expressing H6PDH and 11beta-HSD1, we observe direct physical interaction between the two enzymes. PMID: 19121282

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  • 相關疾病：
    Cortisone reductase deficiency 1 (CORTRD1)
  • 亞細胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Glucose-6-phosphate dehydrogenase family; Glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily
  • 組織特異性：
    Present in most tissues examined, strongest in liver.
  • 數據庫鏈接：

    HGNC: 4795

    OMIM: 138090

    KEGG: hsa:9563

    STRING: 9606.ENSP00000366620

    UniGene: Hs.463511



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