在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. H6PD Antibody, Biotin conjugated

H6PD Antibody, Biotin conjugated

  • 中文名稱：
    H6PD兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA010111LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) H6PD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    H6PD
  • 別名：
    GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363), 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)], H6PD, GDH
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human GDH/6PGL endoplasmic bifunctional protein (422-712aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway. May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate. The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum. By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity.
  • 基因功能參考文獻：
    1. Data indicate the tetramer as the most active form of glucose-6-phosphate dehydrogenase (G6PDH). PMID: 28370139
    2. cortisol reduces glucose-6-phosphate (G6P) flux through H6PDH by increasing luminal NADPH, thereby allowing more G6P for hydrolysis via G6Pase PMID: 26860459
    3. Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death. PMID: 26337086
    4. The G allele of rs6688832 in H6PD might exert potential genetic protective role against the development of PCOS, especially in overweight women. PCOS patients with AG genotype of rs6688832 might confer risk to the phenotype of hyperandrogenemia of PCOS. PMID: 26452272
    5. The aim of the work was to investigate the expression of HSD11B1, HSD11B2, H6PDH, and glucocorticoids receptor (GR) mRNA in subcutaneous adipose tissue (SAT) from obese women with or without polycystic ovary syndrome. PMID: 23979790
    6. Cytoplasmic Mg2+ regulates glucose 6-phosphate utilization by reticular H6PD. PMID: 24631573
    7. GR and p300 are involved in the induction of H6PD by cortisol in human amnion fibroblasts PMID: 23125313
    8. Polymorphisms in the H6PD gene may not be associated with type 2 diabetes and the metabolic syndrome. PMID: 21869537
    9. Antioxidant supplementation was noted to increase G6PDH in the pentose phosphate cycle and 18S rRNA in the ribosome. There were no significant changes in the gene expression levels of beta-ACT PMID: 22285204
    10. R453Q and D151A variants of the H6PD gene are associated with PCOS and obesity, respectively, and may contribute to the PCOS phenotype by influencing obesity, insulin resistance and hyperandrogenism. PMID: 22306327
    11. Results suggest a novel role for the H6PD gene in atherosclerosis susceptibility. PMID: 21858044
    12. the H6PD gene is very polymorphic and missense variants are common, coding variants rarely (<1.5%) are responsible for hyperandrogenemic polycystic ovary syndrome. PMID: 21050867
    13. identified a mitochondrial matrix-associated G6PDH and also provide evidence that metabolic state/glucose availability modulate enzymatic sources of NADPH PMID: 20228249
    14. This study corroborates the association of one locus determined by genome-wide association study and points to H6PD as a new candidate gene for multiple sclerosis. PMID: 19935835
    15. findings indicate that the decrease in G6PDH activity that occurs after exposure of lung epithelial cells to chrysotile results from the carbonylation of G6PDH by TBARS PMID: 20211231
    16. Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. PMID: 12858176
    17. H6PDH directly determines the reaction direction of 11beta-Hydroxysteroid dehydrogenase1 in intact cells as an oxoreductase. PMID: 15280030
    18. A new chemiluminescent method was applied to the determination of G6PDH in healthy and enzyme-deficient individuals. PMID: 15767211
    19. Two new missense mutations in glucose-6-phosphate dehydrogenase gene associated with chronic hemolytic anemia. PMID: 16079115
    20. Mutations found in beta thassemia patients complicated by liver disease. PMID: 16079116
    21. The observed constant expression of H6PD suggests that HSD11B1 acts as a reductase throughout the adipogenesis process in human ADMSCs and murine 3T3-L1 cells. PMID: 18586838
    22. Hepatic 11beta-HSD1 and H6PDH are closely interlinked. 11beta-HSD1 gene expression does not seem to be involved in the pathogenesis of fatty liver or nonalcoholic steatohepatitis. PMID: 18665910
    23. Data show that adipose tissue 11-beta-Hydroxysteroid Dehydrogenase Type 1 and Hexose-6-Phosphate Dehydrogenase gene expressions are increased in patients with type 2 diabetes mellitus. PMID: 18963204
    24. The impact of H6PDH on the modulation of 11beta-HSD1-dependent interconversion of cortisone and cortisol by inhibitors and alternative substrates, was investigated. PMID: 19010388
    25. Using co-immunoprecipitation experiments with purified H6PDH and 11beta-HSD1, and with cell lysates expressing H6PDH and 11beta-HSD1, we observe direct physical interaction between the two enzymes. PMID: 19121282

    顯示更多

    收起更多

  • 相關疾病：
    Cortisone reductase deficiency 1 (CORTRD1)
  • 亞細胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Glucose-6-phosphate dehydrogenase family; Glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily
  • 組織特異性：
    Present in most tissues examined, strongest in liver.
  • 數據庫鏈接：

    HGNC: 4795

    OMIM: 138090

    KEGG: hsa:9563

    STRING: 9606.ENSP00000366620

    UniGene: Hs.463511



主站蜘蛛池模板： 国产一卡2卡3卡四卡精品app| 亚洲第一无码专区天堂| 国产欧美日韩综合视频专区| 久久亚洲一区二区三区舞蹈| 国产男女猛烈视频在线观看| 很黄很色60分钟在线观看| 日日摸日日碰人妻无码| 国产精品自在线拍国产电影| 777米奇影视第四色| 亚洲一区天堂九一| 午夜无码国产理论在线| 五月丁香啪啪| 久久99精品国产麻豆婷婷| 奶真大水真多小荡货av | 美女又大又黄www免费网站| 亚洲成av人片在线播放无码| 久久久久国产精品无码免费看| 女人被狂躁c到高潮| 久久五月丁香激情综合| 久精品视频在线观看免费| 四虎影视在线影院在线观看免费视频 | 992tv精品视频tv在线观看| 精品av综合导航| 真人性囗交69视频| 欧美激情乱人伦| 国产男女猛烈视频在线观看| 久久久久久av无码免费网站 | 秋秋影视午夜福利高清| 无码帝国www无码专区色综合| 国产成人亚洲综合| 性欧美丰满熟妇xxxx性久久久| 午夜福利无遮挡十八禁视频| 久久精品人人做人人综合| 亚洲日韩精品无码专区| 欧美粗大猛烈老熟妇| 国产精品特黄aaaa片在线观看| 午夜色大片在线观看| 亚洲成av人片香蕉片| 黄在线看片免费人成视频 | 欧美40老熟妇色xxxxx| 女人被狂c躁到高潮视频|