在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GUCY1A3 Antibody

  • 中文名稱:
    GUCY1A3兔多克隆抗體
  • 貨號:
    CSB-PA558643
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA558643(GUCY1A3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA558643(GUCY1A3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    GC S alpha 1 antibody; GC SA3 antibody; GCS alpha 1 antibody; GCS alpha 3 antibody; GCS-alpha-1 antibody; GCS-alpha-3 antibody; GCYA3_HUMAN antibody; Guanylate cyclase 1 soluble alpha 3 antibody; Guanylate cyclase soluble subunit alpha 1 antibody; Guanylate cyclase soluble subunit alpha 3 antibody; Guanylate cyclase soluble subunit alpha-3 antibody; Guanylate cyclase; nitric oxide-sensitive; alpha-1 subunit antibody; Guc1a1 antibody; GUC1A3 antibody; GUCA3 antibody; GUCSA3 antibody; Gucy1a1 antibody; Gucy1a3 antibody; MYMY6 antibody; nitric oxide-sensitive Guanylate cyclase; alpha-1 subunit antibody; NOGC; alpha-1 subunit antibody; Soluble guanylate cyclase large subunit antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human GUCY1A3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 基因功能參考文獻:
    1. Human Red Blood Cells carry catalytically active alpha1beta1-soluble guanylate cyclase (isoform 1). Red cell soluble guanylate cyclase activity is fully preserved in patients with stable coronary artery disease. PMID: 29024896
    2. Peptide B-8R killed both androgen-dependent and androgen-independent prostate cancer cells that expressed sGCalpha1, but not cells that do not express this gene. Peptide B-8R induced apoptosis of prostate cancer cells. PMID: 28859127
    3. In conclusion, rare coding variants in GUCY1A3 lead to reduced cGMP formation which can be rescued by a soluble guanylyl cyclase stimulator in vitro PMID: 27342234
    4. Rs7692387 is located in an intronic site that modulates GUCY1A3 promoter activity. The transcription factor ZEB1 binds preferentially to the nonrisk allele, leading to an increase in GUCY1A3 expression, higher sGC levels, and higher sGC activity after stimulation. PMID: 28487391
    5. Mutations in the GUCY1A3 gene are associated with moyamoya disease, achalasia, and hypertension. PMID: 26777256
    6. Expression of the alpha1-A680T sGC variant in reporter cells resulted in higher cyclic guanosine monophosphate production compared with the wild-type enzyme and the purified alpha1-A680T sGC exhibited enhanced sensitivity to nitric oxide in vitro. PMID: 25373139
    7. Dynamic interplay between hsp90, apo-sGC-beta1, and sGC-alpha1 in response to NO is unprecedented and represent new steps by which cells can modulate the heme content and activity of sGC for signaling cascades. PMID: 24733395
    8. ZNF280B upregulates GUCY1A3 expression and downregulates TP53 in prostate cancer cells. PMID: 24236047
    9. homozygous mutations in GUCY1A3, which encodes the alpha1 subunit of soluble guanylate cyclase, the major receptor for nitric oxide, might play a role in moyamoya and achalasia PMID: 24581742
    10. The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase PMID: 22690686
    11. GCS-alpha-1 regulation of p53 activity is important in prostate cancer biology and may represent an important mechanism of p53 down-regulation. PMID: 22174378
    12. We concluded that the alpha-subunit and the beta(1)(191-619) domain exert structural strains on the heme domain. PMID: 22223482
    13. analysis of pharmacological response to direct sGC activators in coronary artery disease patients PMID: 21794866
    14. A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase PMID: 21725643
    15. C-alpha1 sGC splice form is expressed at high levels in differentiating cells and its intracellular distribution varies from canonical alpha1 sGC subunit. PMID: 20964618
    16. NO, depending on its concentration, may act in human PBMCs as a stimulator of IL-6 expression and modulator of NF-KB involving the sGC/cGMP/PKG pathway PMID: 21414799
    17. Soluble guanylate cyclases could be the target molecules for controlling neo-vascularization in a subset of human malignant gliomas. PMID: 15201957
    18. guanylate cyclase has a role in pulmonary arterial hypertension PMID: 18550612

    顯示更多

    收起更多

  • 相關疾病:
    Moyamoya disease 6 with achalasia (MYMY6)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 組織特異性:
    Detected in brain cortex and lung (at protein level).
  • 數據庫鏈接:

    HGNC: 4685

    OMIM: 139396

    KEGG: hsa:2982

    STRING: 9606.ENSP00000296518

    UniGene: Hs.24258



主站蜘蛛池模板: 四虎永久在线精品免费观看视频| 中文字幕人乱码中文| 人妻互换一二三区激情视频 | 美女视频黄频a免费| 国产乱人对白| 亚洲色大成网站www永久麻豆| 韩国的无码av看免费大片在线| 亚洲色无码中文字幕在线| 色噜噜狠狠狠狠色综合久一| 精品人妻少妇一区二区三区在线 | 国产精品99久久久久久宅男小说| 国产成人精品一区二区三区免费| 日韩一本之道一区中文字幕| 无码成人片在线播放| 精品国产高清自在线一区二区| 日产精品久久久久久久蜜臀| 国产强被迫伦姧在线观看无码 | 人人狠狠综合久久88成人| 色综合欧美五月俺也去| 在线观看无码av网址| 精品丰满人妻无套内射| 亚洲成av人综合在线观看| 麻豆国产在线精品国偷产拍| 中文字幕无码热在线视频| 亚洲伊人久久大香线蕉av| 又色又爽又黄的视频软件app| 欧美日韩免费做爰大片人| 亚洲日产av中文字幕无码偷拍| 13小箩利洗澡无码视频网站| 五十路熟女一区二区三区| 秋霞午夜成人久久电影网| 亚洲精品字幕| 无码人妻精品一区二区三区免费| 美女裸免费观看网站| 欧美人与动另类xxxx| 人人妻人人澡人人爽人人精品浪潮| 99在线精品视频在线观看| 国产最新精品自产在线观看| 国产成人a人亚洲精v品无码| 236宅宅理论片免费| 亚洲精品日本一区二区三区 |