在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GUCY1A3 Antibody

  • 中文名稱:
    GUCY1A3兔多克隆抗體
  • 貨號:
    CSB-PA558643
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA558643(GUCY1A3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA558643(GUCY1A3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    GC S alpha 1 antibody; GC SA3 antibody; GCS alpha 1 antibody; GCS alpha 3 antibody; GCS-alpha-1 antibody; GCS-alpha-3 antibody; GCYA3_HUMAN antibody; Guanylate cyclase 1 soluble alpha 3 antibody; Guanylate cyclase soluble subunit alpha 1 antibody; Guanylate cyclase soluble subunit alpha 3 antibody; Guanylate cyclase soluble subunit alpha-3 antibody; Guanylate cyclase; nitric oxide-sensitive; alpha-1 subunit antibody; Guc1a1 antibody; GUC1A3 antibody; GUCA3 antibody; GUCSA3 antibody; Gucy1a1 antibody; Gucy1a3 antibody; MYMY6 antibody; nitric oxide-sensitive Guanylate cyclase; alpha-1 subunit antibody; NOGC; alpha-1 subunit antibody; Soluble guanylate cyclase large subunit antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human GUCY1A3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 基因功能參考文獻:
    1. Human Red Blood Cells carry catalytically active alpha1beta1-soluble guanylate cyclase (isoform 1). Red cell soluble guanylate cyclase activity is fully preserved in patients with stable coronary artery disease. PMID: 29024896
    2. Peptide B-8R killed both androgen-dependent and androgen-independent prostate cancer cells that expressed sGCalpha1, but not cells that do not express this gene. Peptide B-8R induced apoptosis of prostate cancer cells. PMID: 28859127
    3. In conclusion, rare coding variants in GUCY1A3 lead to reduced cGMP formation which can be rescued by a soluble guanylyl cyclase stimulator in vitro PMID: 27342234
    4. Rs7692387 is located in an intronic site that modulates GUCY1A3 promoter activity. The transcription factor ZEB1 binds preferentially to the nonrisk allele, leading to an increase in GUCY1A3 expression, higher sGC levels, and higher sGC activity after stimulation. PMID: 28487391
    5. Mutations in the GUCY1A3 gene are associated with moyamoya disease, achalasia, and hypertension. PMID: 26777256
    6. Expression of the alpha1-A680T sGC variant in reporter cells resulted in higher cyclic guanosine monophosphate production compared with the wild-type enzyme and the purified alpha1-A680T sGC exhibited enhanced sensitivity to nitric oxide in vitro. PMID: 25373139
    7. Dynamic interplay between hsp90, apo-sGC-beta1, and sGC-alpha1 in response to NO is unprecedented and represent new steps by which cells can modulate the heme content and activity of sGC for signaling cascades. PMID: 24733395
    8. ZNF280B upregulates GUCY1A3 expression and downregulates TP53 in prostate cancer cells. PMID: 24236047
    9. homozygous mutations in GUCY1A3, which encodes the alpha1 subunit of soluble guanylate cyclase, the major receptor for nitric oxide, might play a role in moyamoya and achalasia PMID: 24581742
    10. The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase PMID: 22690686
    11. GCS-alpha-1 regulation of p53 activity is important in prostate cancer biology and may represent an important mechanism of p53 down-regulation. PMID: 22174378
    12. We concluded that the alpha-subunit and the beta(1)(191-619) domain exert structural strains on the heme domain. PMID: 22223482
    13. analysis of pharmacological response to direct sGC activators in coronary artery disease patients PMID: 21794866
    14. A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase PMID: 21725643
    15. C-alpha1 sGC splice form is expressed at high levels in differentiating cells and its intracellular distribution varies from canonical alpha1 sGC subunit. PMID: 20964618
    16. NO, depending on its concentration, may act in human PBMCs as a stimulator of IL-6 expression and modulator of NF-KB involving the sGC/cGMP/PKG pathway PMID: 21414799
    17. Soluble guanylate cyclases could be the target molecules for controlling neo-vascularization in a subset of human malignant gliomas. PMID: 15201957
    18. guanylate cyclase has a role in pulmonary arterial hypertension PMID: 18550612

    顯示更多

    收起更多

  • 相關疾病:
    Moyamoya disease 6 with achalasia (MYMY6)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 組織特異性:
    Detected in brain cortex and lung (at protein level).
  • 數據庫鏈接:

    HGNC: 4685

    OMIM: 139396

    KEGG: hsa:2982

    STRING: 9606.ENSP00000296518

    UniGene: Hs.24258



主站蜘蛛池模板: 亚洲 欧洲 日韩 综合av| 免费国产黄网在线观看| 国产女人高潮叫床免费视频| 人妻丰满熟妇ⅴ无码区a片| 国产无吗一区二区三区在线欢| 伦埋琪琪电影院久久| 狼人大香伊蕉国产www亚洲| 天天爱天天做久久狠狠做| 日韩精品 中文字幕 视频在线 | 中文在线а天堂中文在线新版| 99er国产这里只有精品视频免费| 宅男宅女精品国产av天堂| 免费国产va在线观看中文字| 被拉到野外强要好爽黑人| 法国伦理少妇愉情| 国产精品国色综合久久| 美女黄频视频大全免费的国内| 国产精品久久久久无码av1| 日日碰狠狠添天天爽| 老司机午夜免费精品视频| 欧美成人看片一区二三区图文| 无码免费中文字幕视频| 欧美丰满老妇性猛交| 尤物av无码色av无码| 亚洲国产精品一区二区动图| 99热网址最新获取域名| 日本一卡二卡3卡四卡网站精品 | 国产特级毛片aaaaaa| 女性自慰网站免费观看w| 日韩少妇人妻vs中文字幕| 香蕉久久福利院| 最新国产精品自在线观看| 国产欧洲精品自在自线官方| 国产高清不卡一区二区| 国产女主播白浆在线观看| 免费无人区男男码卡二卡| 国产精品∧v在线观看| 国产av一区二区三区传媒| 久久精品国产99久久香蕉| 中国少妇内射xxxxx-百度 | 久久天天躁狠狠躁夜夜躁app|