在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GUCY1A1 Antibody, HRP conjugated

  • 中文名稱:
    GUCY1A1 兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA010050LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GUCY1A1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    GC S alpha 1 antibody; GC SA3 antibody; GCS alpha 1 antibody; GCS alpha 3 antibody; GCS-alpha-1 antibody; GCS-alpha-3 antibody; GCYA3_HUMAN antibody; Guanylate cyclase 1 soluble alpha 3 antibody; Guanylate cyclase soluble subunit alpha 1 antibody; Guanylate cyclase soluble subunit alpha 3 antibody; Guanylate cyclase soluble subunit alpha-3 antibody; Guanylate cyclase; nitric oxide-sensitive; alpha-1 subunit antibody; Guc1a1 antibody; GUC1A3 antibody; GUCA3 antibody; GUCSA3 antibody; Gucy1a1 antibody; Gucy1a3 antibody; MYMY6 antibody; nitric oxide-sensitive Guanylate cyclase; alpha-1 subunit antibody; NOGC; alpha-1 subunit antibody; Soluble guanylate cyclase large subunit antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Guanylate cyclase soluble subunit alpha-1 protein (20-152AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn):
    1. Human Red Blood Cells carry catalytically active alpha1beta1-soluble guanylate cyclase (isoform 1). Red cell soluble guanylate cyclase activity is fully preserved in patients with stable coronary artery disease. PMID: 29024896
    2. Peptide B-8R killed both androgen-dependent and androgen-independent prostate cancer cells that expressed sGCalpha1, but not cells that do not express this gene. Peptide B-8R induced apoptosis of prostate cancer cells. PMID: 28859127
    3. In conclusion, rare coding variants in GUCY1A3 lead to reduced cGMP formation which can be rescued by a soluble guanylyl cyclase stimulator in vitro PMID: 27342234
    4. Rs7692387 is located in an intronic site that modulates GUCY1A3 promoter activity. The transcription factor ZEB1 binds preferentially to the nonrisk allele, leading to an increase in GUCY1A3 expression, higher sGC levels, and higher sGC activity after stimulation. PMID: 28487391
    5. Mutations in the GUCY1A3 gene are associated with moyamoya disease, achalasia, and hypertension. PMID: 26777256
    6. Expression of the alpha1-A680T sGC variant in reporter cells resulted in higher cyclic guanosine monophosphate production compared with the wild-type enzyme and the purified alpha1-A680T sGC exhibited enhanced sensitivity to nitric oxide in vitro. PMID: 25373139
    7. Dynamic interplay between hsp90, apo-sGC-beta1, and sGC-alpha1 in response to NO is unprecedented and represent new steps by which cells can modulate the heme content and activity of sGC for signaling cascades. PMID: 24733395
    8. ZNF280B upregulates GUCY1A3 expression and downregulates TP53 in prostate cancer cells. PMID: 24236047
    9. homozygous mutations in GUCY1A3, which encodes the alpha1 subunit of soluble guanylate cyclase, the major receptor for nitric oxide, might play a role in moyamoya and achalasia PMID: 24581742
    10. The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase PMID: 22690686
    11. GCS-alpha-1 regulation of p53 activity is important in prostate cancer biology and may represent an important mechanism of p53 down-regulation. PMID: 22174378
    12. We concluded that the alpha-subunit and the beta(1)(191-619) domain exert structural strains on the heme domain. PMID: 22223482
    13. analysis of pharmacological response to direct sGC activators in coronary artery disease patients PMID: 21794866
    14. A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase PMID: 21725643
    15. C-alpha1 sGC splice form is expressed at high levels in differentiating cells and its intracellular distribution varies from canonical alpha1 sGC subunit. PMID: 20964618
    16. NO, depending on its concentration, may act in human PBMCs as a stimulator of IL-6 expression and modulator of NF-KB involving the sGC/cGMP/PKG pathway PMID: 21414799
    17. Soluble guanylate cyclases could be the target molecules for controlling neo-vascularization in a subset of human malignant gliomas. PMID: 15201957
    18. guanylate cyclase has a role in pulmonary arterial hypertension PMID: 18550612

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Moyamoya disease 6 with achalasia (MYMY6)
  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 組織特異性:
    Detected in brain cortex and lung (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4685

    OMIM: 139396

    KEGG: hsa:2982

    STRING: 9606.ENSP00000296518

    UniGene: Hs.24258



主站蜘蛛池模板: 四川老熟女下面又黑又肥| 国产精品久久久久久av| 少妇人妻偷人精品视蜜桃| 欧美成人秋霞久久aa片| 天堂在/线中文在线资源8| 97国产一区二区三区四区久久 | 最新国产精品无码| 国产激情一区二区三区| 久久这里只精品国产免费10| 国产亚洲高清国产拍精品| 日韩av无码一区二区三区无码| 中文字幕乱码在线人视频| 久久躁狠狠躁夜夜av| 人人澡人摸人人添| 国产无遮挡又黄又爽动态图| 久久久精品人妻一区二区三区四| 日韩国产成人精品视频| 两个美女裸体舌吻互扒内裤| 中文字幕大看蕉在线观看| 人人妻人人澡av| 欧美激情精品久久久久久| 国产精品久久香蕉免费播放| 日韩v亚洲v欧美v精品综合| 亚洲精品无码不卡| 国语做受对白xxxxx在线| 成人av片在线观看免费| 男人和女人做爽爽视频| 天天爽夜夜爽夜夜爽精品视频| 国产精品_国产精品_k频道| 国产无套粉嫩白浆在线观看 | 99国精品午夜福利视频不卡 | 国产嫖妓一区二区三区无码 | 亚洲制服丝袜自拍中文字幕| 插b内射18免费视频| 欧美人与物videos另类xxxxx| 国产沙发午睡系列999| 亚洲人亚洲人成电影网站色| 人妻熟妇乱又伦精品视频中文字幕 | 97高清国语自产拍| 久久精品女人天堂av| 2021国产精品国产精华|