在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GUCY1A3 Antibody

GUCY1A3 Antibody

  • 中文名稱：
    GUCY1A3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA173685
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA173685(GUCY1A3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA173685(GUCY1A3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    GC S alpha 1 antibody; GC SA3 antibody; GCS alpha 1 antibody; GCS alpha 3 antibody; GCS-alpha-1 antibody; GCS-alpha-3 antibody; GCYA3_HUMAN antibody; Guanylate cyclase 1 soluble alpha 3 antibody; Guanylate cyclase soluble subunit alpha 1 antibody; Guanylate cyclase soluble subunit alpha 3 antibody; Guanylate cyclase soluble subunit alpha-3 antibody; Guanylate cyclase; nitric oxide-sensitive; alpha-1 subunit antibody; Guc1a1 antibody; GUC1A3 antibody; GUCA3 antibody; GUCSA3 antibody; Gucy1a1 antibody; Gucy1a3 antibody; MYMY6 antibody; nitric oxide-sensitive Guanylate cyclase; alpha-1 subunit antibody; NOGC; alpha-1 subunit antibody; Soluble guanylate cyclase large subunit antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human GUCY1A3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. Human Red Blood Cells carry catalytically active alpha1beta1-soluble guanylate cyclase (isoform 1). Red cell soluble guanylate cyclase activity is fully preserved in patients with stable coronary artery disease. PMID: 29024896
    2. Peptide B-8R killed both androgen-dependent and androgen-independent prostate cancer cells that expressed sGCalpha1, but not cells that do not express this gene. Peptide B-8R induced apoptosis of prostate cancer cells. PMID: 28859127
    3. In conclusion, rare coding variants in GUCY1A3 lead to reduced cGMP formation which can be rescued by a soluble guanylyl cyclase stimulator in vitro PMID: 27342234
    4. Rs7692387 is located in an intronic site that modulates GUCY1A3 promoter activity. The transcription factor ZEB1 binds preferentially to the nonrisk allele, leading to an increase in GUCY1A3 expression, higher sGC levels, and higher sGC activity after stimulation. PMID: 28487391
    5. Mutations in the GUCY1A3 gene are associated with moyamoya disease, achalasia, and hypertension. PMID: 26777256
    6. Expression of the alpha1-A680T sGC variant in reporter cells resulted in higher cyclic guanosine monophosphate production compared with the wild-type enzyme and the purified alpha1-A680T sGC exhibited enhanced sensitivity to nitric oxide in vitro. PMID: 25373139
    7. Dynamic interplay between hsp90, apo-sGC-beta1, and sGC-alpha1 in response to NO is unprecedented and represent new steps by which cells can modulate the heme content and activity of sGC for signaling cascades. PMID: 24733395
    8. ZNF280B upregulates GUCY1A3 expression and downregulates TP53 in prostate cancer cells. PMID: 24236047
    9. homozygous mutations in GUCY1A3, which encodes the alpha1 subunit of soluble guanylate cyclase, the major receptor for nitric oxide, might play a role in moyamoya and achalasia PMID: 24581742
    10. The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase PMID: 22690686
    11. GCS-alpha-1 regulation of p53 activity is important in prostate cancer biology and may represent an important mechanism of p53 down-regulation. PMID: 22174378
    12. We concluded that the alpha-subunit and the beta(1)(191-619) domain exert structural strains on the heme domain. PMID: 22223482
    13. analysis of pharmacological response to direct sGC activators in coronary artery disease patients PMID: 21794866
    14. A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase PMID: 21725643
    15. C-alpha1 sGC splice form is expressed at high levels in differentiating cells and its intracellular distribution varies from canonical alpha1 sGC subunit. PMID: 20964618
    16. NO, depending on its concentration, may act in human PBMCs as a stimulator of IL-6 expression and modulator of NF-KB involving the sGC/cGMP/PKG pathway PMID: 21414799
    17. Soluble guanylate cyclases could be the target molecules for controlling neo-vascularization in a subset of human malignant gliomas. PMID: 15201957
    18. guanylate cyclase has a role in pulmonary arterial hypertension PMID: 18550612

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Moyamoya disease 6 with achalasia (MYMY6)
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 組織特異性：
    Detected in brain cortex and lung (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4685

    OMIM: 139396

    KEGG: hsa:2982

    STRING: 9606.ENSP00000296518

    UniGene: Hs.24258



主站蜘蛛池模板： 中文字幕在线观看| 中文字幕 人妻熟女| 日韩成人无码一区二区三区| 两个人日本www免费版| 欧美日韩一区二区三区自拍| 成人精品视频99在线观看免费| 衣服被扒开强摸双乳18禁网站| 动漫精品啪啪一区二区三区| 久久久久噜噜噜亚洲熟女综合 | 国产精品日韩欧美一区二区三区| 伊人www22综合色| 亚洲精品1卡2卡三卡4卡乱码| 国产精品亚洲а∨天堂| 精品国模一区二区三区| 欧美顶级少妇作爱| 国产av激情无码久久| 乱中年女人伦av二区| 狠狠躁天天躁无码中文字幕| 国产色xx群视频射精| 老湿机69福利区18禁网站| 亚洲国产精品va在线观看麻豆| 欧美三级在线播放| 欧美黑人又粗又大高潮喷水| 久久综合给合久久国产免费| 在教室伦流澡到高潮h麻豆| 国产成人无码一区二区三区| 女人被弄到高潮的免费视频| 亚洲高清国产av拍精品青青草原| 欧美性大战xxxxx久久久√| 成人艳情一二三区| √天堂资源地址在线官网| 亚洲h成年动漫在线观看网站| 欧美精品videossex少妇| 国产中老年妇女精品| 中文无码精品a∨在线观看| 国产第一页浮力影院草草| 伊伊综合在线视频无码| 一本一道vs无码中文字幕| 中文字幕av无码免费久久| 丝袜 中出 制服 人妻 美腿| 5x性社区免费视频播|