在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GRM4 Antibody

GRM4 Antibody

  • 中文名稱：
    GRM4兔多克隆抗體
  • 貨號：
    CSB-PA923348
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA923348(GRM4 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Glutamate receptor metabotropic 4 antibody; GPRC1D antibody; Grm4 antibody; GRM4_HUMAN antibody; Metabotropic glutamate receptor 4 antibody; mGlu4 antibody; mGluR4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human GRM4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
  • 基因功能參考文獻：
    1. EGR1 and CTCF are probably involved in the transcriptional regulation of GRM4, which participates in the progress of osteosarcoma by interacting with chemokines and their receptors. PMID: 29339716
    2. Results suggest that variant rs2229901 of glutamate receptor 4 is associated with major depressive disorder risk. This variant probably impacts the interaction between GRM4 and miR-1202. PMID: 27792966
    3. Our data suggest that GRM4 gene polymorphism is closely related to the morbidity and metastasis of osteosarcoma in a Chinese population. PMID: 26276359
    4. The GRM4 gene polymorphism was associated with the susceptibility and metastasis of osteosarcoma in a Chinese Han population. PMID: 24984297
    5. study found that only one of the five SNPs tested showed a moderate but statistically significant association with juvenile myoclonic epilepsy in an Indian population PMID: 24840839
    6. The major depression subjects exhibited significantly higher expression level in the metabotropic receptor genes GRM4 in Locus coeruleus neurons. PMID: 24925192
    7. explored the relationship between the binding pockets of mGlu4-positive allosteric modulators with different chemical scaffolds and their functional properties PMID: 25342125
    8. Data show that mGlu2 and mGlu4 subunits (but not mGlu2 and mGlu1) can heteromerize. PMID: 20826542
    9. GRM4 sequence variants might confer low-risk effects to the etiology of idiopathic generalized epilepsies. PMID: 20338729
    10. residues shaping the binding pocket determine ligand selectivity for mGLUR4 PMID: 15184361
    11. mGluR4 has a role in 5-FU resistance in colonic neoplasms PMID: 15217955
    12. Results suggest that overexpression of mGluR4 is associated with poor prognosis. PMID: 15867225
    13. mGluR4 internalization and desensitization are agonist-independent unless pathways leading to the activation of PKC are induced. PMID: 16582932
    14. These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas. PMID: 16899734
    15. the effects of P-Ser (inhibition of neural stem cell proliferation and self-renewal, enhanced neurogenic fate commitment, and improved neuronal survival) are mediated bymGluR4. PMID: 17884634

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 組織特異性：
    Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.
  • 數據庫鏈接：

    HGNC: 4596

    OMIM: 604100

    KEGG: hsa:2914

    STRING: 9606.ENSP00000363296

    UniGene: Hs.429018



主站蜘蛛池模板： 精品少妇无码av无码专区| 无码帝国www无码专区色综合 | 18禁无遮挡免费视频网站| 欧美 日韩 亚洲 在线| 在线观看高h无码黄动漫| 在线天堂中文官网| 亚洲精品国产suv一区| 色哟哟网站在线观看| 国产成人精品久久一区二区| 欧洲美女黑人粗性暴交| www亚洲精品少妇裸乳一区二区 | 亚洲另类无码一区二区三区| 黑人巨大跨种族video| 国产超碰人人模人人爽人人喊| 亚洲va成无码人在线观看天堂| 亚洲人成无码网站久久99热国产 | 国产精品门事件av| 国产免费艾彩sm调教视频 | 国产日韩欧美不卡在线二区| 少妇粉嫩小泬白浆流出| 久久国产精品一国产精品| 777米奇影视第四色| 中文字幕久精品免费视频| 鲁鲁狠狠狠7777一区二区| 最新亚洲春色av无码专区| 美女把尿囗扒开让男人添| 精品久久久久久久国产潘金莲| 窝窝午夜色视频国产精品破 | 精品亚洲成a人无码成a在线观看| 欧美性受xxxx黑人xyx性爽 | 国产亚洲精品久久yy50| 亚洲18色成人网站www | 被窝影院午夜无码国产| 狠狠色狠狠色综合网| 国产日韩综合一区二区性色av| 日韩亚洲中字无码一区二区三区| 午夜一区二区亚洲福利| 国产精品白丝喷水在线观看| 亚洲狠狠色成人综合网| 日本日本乱码伦专区| 成年性午夜免费视频网站|