在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GRM4 Antibody

GRM4 Antibody

  • 中文名稱：
    GRM4兔多克隆抗體
  • 貨號：
    CSB-PA116412
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA116412(GRM4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA116412(GRM4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Glutamate receptor metabotropic 4 antibody; GPRC1D antibody; Grm4 antibody; GRM4_HUMAN antibody; Metabotropic glutamate receptor 4 antibody; mGlu4 antibody; mGluR4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human GRM4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
  • 基因功能參考文獻：
    1. EGR1 and CTCF are probably involved in the transcriptional regulation of GRM4, which participates in the progress of osteosarcoma by interacting with chemokines and their receptors. PMID: 29339716
    2. Results suggest that variant rs2229901 of glutamate receptor 4 is associated with major depressive disorder risk. This variant probably impacts the interaction between GRM4 and miR-1202. PMID: 27792966
    3. Our data suggest that GRM4 gene polymorphism is closely related to the morbidity and metastasis of osteosarcoma in a Chinese population. PMID: 26276359
    4. The GRM4 gene polymorphism was associated with the susceptibility and metastasis of osteosarcoma in a Chinese Han population. PMID: 24984297
    5. study found that only one of the five SNPs tested showed a moderate but statistically significant association with juvenile myoclonic epilepsy in an Indian population PMID: 24840839
    6. The major depression subjects exhibited significantly higher expression level in the metabotropic receptor genes GRM4 in Locus coeruleus neurons. PMID: 24925192
    7. explored the relationship between the binding pockets of mGlu4-positive allosteric modulators with different chemical scaffolds and their functional properties PMID: 25342125
    8. Data show that mGlu2 and mGlu4 subunits (but not mGlu2 and mGlu1) can heteromerize. PMID: 20826542
    9. GRM4 sequence variants might confer low-risk effects to the etiology of idiopathic generalized epilepsies. PMID: 20338729
    10. residues shaping the binding pocket determine ligand selectivity for mGLUR4 PMID: 15184361
    11. mGluR4 has a role in 5-FU resistance in colonic neoplasms PMID: 15217955
    12. Results suggest that overexpression of mGluR4 is associated with poor prognosis. PMID: 15867225
    13. mGluR4 internalization and desensitization are agonist-independent unless pathways leading to the activation of PKC are induced. PMID: 16582932
    14. These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas. PMID: 16899734
    15. the effects of P-Ser (inhibition of neural stem cell proliferation and self-renewal, enhanced neurogenic fate commitment, and improved neuronal survival) are mediated bymGluR4. PMID: 17884634

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 組織特異性：
    Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.
  • 數據庫鏈接：

    HGNC: 4596

    OMIM: 604100

    KEGG: hsa:2914

    STRING: 9606.ENSP00000363296

    UniGene: Hs.429018



主站蜘蛛池模板： 国产精品嫩草影院入口一二三| 日本一卡2卡3卡4卡无卡免费网站| 狠狠人妻久久久久久综合蜜桃| 荫蒂被男人添的好舒服爽免费视频 | 欧美性受xxxx狂喷水| 亚洲人成亚洲人成在线观看 | 精品国产乱码一区二区三区| 国产成人精品一区二三区在线观看| 337p日本欧洲亚洲大胆色噜噜| 午夜福利体验免费体验区| 亚洲精品国产精品乱码不卡| 又粗又猛又黄又爽无遮挡| 中文字幕久精品免费视频| awww在线天堂bd资源在线| 丰满少妇呻吟高潮经历| 无码h肉动漫在线观看| 国产精品美女久久久久久| 又色又爽又高潮免费观看| 国产精品美女久久久久久2021| 国产女人抽搐喷浆视频| 中文字幕人妻互换av久久| 免费人成视频在线| 亚洲日韩av片在线观看| 极品无码国模国产在线观看| 婷婷网色偷偷亚洲男人甘肃| 久久国产精品无码一区二区三区| 永久免费无码日韩视频| 18禁真人抽搐一进一出在线| 亚洲精品国产成人无码区a片| 香蕉久久人人97超碰caoproen| 日韩少妇内射免费播放18禁裸乳| 色哟哟国产精品免费观看 | 久久久www成人免费看片| 在线观看国产精品av| 欧美极品少妇×xxxbbb| 蜜臀av午夜一区二区三区| 九九热线有精品视频| 奇米影视色777四色在线首页| 国产精品高清网站| 欧美 日韩 人妻 高清 中文| 国产va免费精品高清在线|