在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GRIN2C Antibody

GRIN2C Antibody

  • 中文名稱：
    GRIN2C兔多克隆抗體
  • 貨號(hào)：
    CSB-PA583461
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA583461(GRIN2C Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    GluN2C antibody; Glutamate [NMDA] receptor subunit epsilon-3 antibody; Glutamate Receptor Ionotropic N Methyl D Aspartate 2C antibody; Glutamate receptor ionotropic, NMDA 2C antibody; Glutamate receptor, ionotropic, N methyl D aspartate 2C antibody; Grin2c antibody; N Methly D Aspartate Receptor Channel Subunit Epsilon 3 antibody; N Methyl D Aspartate Receptor Subtype 2C antibody; N methyl D aspartate receptor subunit 2C antibody; N-methyl D-aspartate receptor subtype 2C antibody; NMDAR2C antibody; NMDE3_HUMAN antibody; NR2C antibody; OTTHUMP00000041930 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human GRIN2C
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:100-1:300
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning.
  • 基因功能參考文獻(xiàn)：
    1. ultra-rare variants with loss of function (frameshift, nonsense or splice site) in NMDARs genes like GRIN2C and GRIN2D may contribute to possible risk of schizophrenia PMID: 29317596
    2. Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk. PMID: 26289945
    3. these findings highlight the isoform-specific structural and functional differences within the 14-3-3 family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface PMID: 26229101
    4. The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2C. PMID: 24925192
    5. TNFalpha significantly upregulates NMDA-R2C mRNA expression, in differentiated, confluent, normal keratinocytes but not in involved or uninvolved psoriatic keratinocyte monolayers PMID: 24102971
    6. The authors identified and cloned sequences of NMDA receptor subunits 2A, 2B, and 2C from rat. They characterized the properties of the receptors composed of heteromeric 1-2A and heteromeric 1-2C and found that the latter had reduced sensitivity to magnesium and smaller conductance compared to the former. PMID: 1350383
    7. Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 family genes. PMID: 22833210

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, NR2C/GRIN2C subfamily
  • 組織特異性：
    Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4587

    OMIM: 138254

    KEGG: hsa:2905

    STRING: 9606.ENSP00000293190

    UniGene: Hs.436980



主站蜘蛛池模板： 狠狠色噜噜狠狠狠狠777米奇| 熟女人妻在线视频| 人人澡人人曰人人摸看| 少妇高潮毛片免费看| 天堂а√中文在线| 久久久中文久久久无码| 亚洲成a人片在线观看中文无码| 亚洲 欧美 日产 综合 在线| 亚洲成a人片77777kkkk| 中文字幕精品一区二区2021年| 青青草国产精品欧美成人| 级毛片内射视频| 亚洲精品无码久久久| 亚洲精品一区二区精华液| 国语精品福利自产拍在线观看| 国产无遮挡又黄又爽免费视频| 奇米四色7777中文字幕| 无码国内精品人妻少妇蜜桃视频| 欧洲亚洲色视频综合在线| 人妻少妇精品视频无码综合| 大桥久未无码吹潮在线观看| 永久免费看啪啪网址入口| 本道久久综合无码中文字幕| 国产voyeur精品偷窥222| 精品乱码一区二区三四区视频 | 岛国4k人妻一区二区三区| 久久久精品人妻一区二区三区 | 亚洲日韩看片无码超清| 女人喷水高潮时的视频网站| 伊人www22综合色| 东京热无码av男人的天堂| 日本欧美大码aⅴ在线播放 | 中国极品少妇videossexhd| 色播在线精品一区二区三区四区| 午夜在线a亚洲v天堂网2018| 亚洲精品动漫免费二区| 欧美人妻aⅴ中文字幕| 天堂网在线观看| 亚洲中文综合网五月俺也去| 精品第一国产综合精品蜜芽| 国内自产少妇自拍区免费|