在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Glutamate [NMDA] receptor subunit epsilon-3 (GRIN2C), partial

  • 中文名稱:
    人GRIN2C重組蛋白
  • 貨號:
    CSB-YP621798HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人GRIN2C重組蛋白
  • 貨號:
    CSB-EP621798HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人GRIN2C重組蛋白
  • 貨號:
    CSB-EP621798HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人GRIN2C重組蛋白
  • 貨號:
    CSB-BP621798HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人GRIN2C重組蛋白
  • 貨號:
    CSB-MP621798HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    GluN2C; Glutamate [NMDA] receptor subunit epsilon-3; Glutamate Receptor Ionotropic N Methyl D Aspartate 2C; Glutamate receptor ionotropic, NMDA 2C; Glutamate receptor, ionotropic, N methyl D aspartate 2C; Grin2c; N Methly D Aspartate Receptor Channel Subunit Epsilon 3; N Methyl D Aspartate Receptor Subtype 2C; N methyl D aspartate receptor subunit 2C; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NMDE3_HUMAN; NR2C; OTTHUMP00000041930
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning.
  • 基因功能參考文獻:
    1. ultra-rare variants with loss of function (frameshift, nonsense or splice site) in NMDARs genes like GRIN2C and GRIN2D may contribute to possible risk of schizophrenia PMID: 29317596
    2. Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk. PMID: 26289945
    3. these findings highlight the isoform-specific structural and functional differences within the 14-3-3 family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface PMID: 26229101
    4. The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2C. PMID: 24925192
    5. TNFalpha significantly upregulates NMDA-R2C mRNA expression, in differentiated, confluent, normal keratinocytes but not in involved or uninvolved psoriatic keratinocyte monolayers PMID: 24102971
    6. The authors identified and cloned sequences of NMDA receptor subunits 2A, 2B, and 2C from rat. They characterized the properties of the receptors composed of heteromeric 1-2A and heteromeric 1-2C and found that the latter had reduced sensitivity to magnesium and smaller conductance compared to the former. PMID: 1350383
    7. Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 family genes. PMID: 22833210

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Glutamate-gated ion channel (TC 1.A.10.1) family, NR2C/GRIN2C subfamily
  • 組織特異性:
    Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4587

    OMIM: 138254

    KEGG: hsa:2905

    STRING: 9606.ENSP00000293190

    UniGene: Hs.436980



主站蜘蛛池模板: 久久久亚洲精品成人| 国产免费人成网站x8x8| 日本真人边吃奶边做爽电影| 人人爽人人爱| 日韩超碰人人爽人人做人人添 | 亚洲国产av无码综合原创国产 | 久久久国产精华液| 青乐娱精品视频一国产分类| 国产欧美亚洲日韩图片| 中文无码vr最新无码av专区| 国产又色又爽又刺激视频| 久久视频这里只有精品在线观看| 夜夜爱夜鲁夜鲁很鲁| 特黄aaaaaaaaa毛片免费视频| 性无码免费一区二区三区在线| 暖暖视频 免费 日本社区| 国产午夜成人免费看片app | 欧美人与动人物姣配xxxx| 中文字幕精品亚洲人成在线| 免费又黄又硬又爽大片| 天天做天天爱天天综合网2021 | 一本清日本在线视频精品| 亚瑟国产精品久久| 日本新janpanese乱熟| 一本久道久久综合久久爱| 东北妇女xx做爰视频| 无码人妻av一区二区三区蜜臀| 色综合天天视频在线观看| 精品av一区二区久久久| 毛片免费视频| 色综合色狠狠天天综合色| 国产亚洲综合欧美视频 | 毛片免费视频观看| 亚洲熟女综合一区二区三区| 国产午夜亚洲精品一区| 国产情侣一区二区| 天天做天天爱夜夜爽| 国产精品女主播主要上线| 在线日韩av免费永久观看| 中国浓毛少妇毛茸茸| 奶真大水真多小荡货av|