在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GRB14 Antibody

GRB14 Antibody

  • 中文名稱：
    GRB14兔多克隆抗體
  • 貨號：
    CSB-PA900627
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA900627(GRB14 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA900627(GRB14 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal intestines tissue, Primary antibody: CSB-PA900627(GRB14 Antibody) at dilution 1/350 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    GRB14
  • 別名：
    GRB14Growth factor receptor-bound protein 14 antibody; GRB14 adapter protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human GRB14
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
  • 基因功能參考文獻：
    1. We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin sensitivity. PMID: 27281273
    2. The N-terminus of the BPS domain plays an important role in the regulation of human Grb14 and insulin receptor complex formation through phosphorylation, in addition to other domains. PMID: 28130417
    3. Colorectal cancer patients with high GRB14 levels had a shorter survival and GRB14 was upregulated at an advanced clinical stage with enhanced tumor invasion and lymph node metastasis. PMID: 26965150
    4. Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor. PMID: 24535599
    5. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3, GRB14 PMID: 23670221
    6. Modulation of mouse rod photoreceptor responses by Grb14 protein. PMID: 24273167
    7. ANKRD55 rs459193 and GRB14 rs13389219 associate with insulin resistance. PMID: 23457408
    8. Grb14 is the first negative regulator of CEACAM3-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact PMID: 22948154
    9. A new role for Grb14 in finely tuning receptor signaling and modulating thyroid cancer progression. PMID: 22158039
    10. serves as an adaptor protein to recruit 3-phosphoinositede-dependent kinase-1 to activated insulin receptor, thus promoting Akt phosphorylation and transduction of the insulin signal PMID: 15210700
    11. regulation of Grb14 expression levels in response to hormonal stimuli, and are consistent with its role as a repressor of insulin signaling where it is induced as a negative feedback mechanism. PMID: 15372466
    12. Grb14 may regulate signalling through the insulin receptor by controlling its tyrosine dephosphorylation in a site-specific manner. PMID: 16582879
    13. GRB14 is a weight-loss-responsive gene in skeletal muscle. Its observed transcriptional modulation may improve insulin signaling, with weight loss. PMID: 16849634
    14. Grb14 regulates insulin action at two levels, through insulin receptors binding and by interfering with downstream pathways. PMID: 19359342

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Endosome membrane; Peripheral membrane protein.
  • 蛋白家族：
    GRB7/10/14 family
  • 組織特異性：
    Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 4565

    OMIM: 601524

    KEGG: hsa:2888

    STRING: 9606.ENSP00000263915

    UniGene: Hs.411881



主站蜘蛛池模板： 丰满岳乱妇在线观看中字无码| 色综合久久婷婷五月| 少妇性俱乐部纵欲狂欢电影| 亚洲午夜无码极品久久| 欧美特黄特色三级视频在线观看| 亚洲精品在看在线观看高清| 老熟女乱子伦| 小12萝8禁在线喷水观看| 手机看黄av免费网址| 日韩午夜理论免费tv影院| 精品丝袜国产自在线拍小草| 久久久久九九精品影院| 特级无码毛片免费视频尤物| 捆绑白丝粉色jk震动捧喷白浆| 性色香蕉av久久久天天网| 中文字幕网伦射乱中文| 日本高清视频网站www| 欧美婷婷六月丁香综合| 日本免费一区二区三区| 狠狠色噜噜狠狠狠8888米奇| 无码国产成人午夜视频在线播放| 久久久亚洲精品av无码| 精品97国产免费人成视频| 蜜臀久久99精品久久久久久| 天天澡天天揉揉av在线| 亚洲欧美日韩成人综合一区| 处破痛哭a√18成年片免费 | 亚洲成色综合网站在线| 精品国产卡一卡2卡3卡| 性色av无码一区二区三区人妻| 国产成人无码精品久久久性色| 中文字幕av无码人妻| 亚洲高清毛片一区二区| 性欧美激情aa片在线播放| 日韩欧无码一区二区三区免费不卡| 国产日产欧产美韩系列影片| 色国产精品一区在线观看| 老司机久久99久久精品播放| 欧美亚洲另类自拍丝袜| 婷婷五月综合激情| 亚洲精品国产成人精品|