在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GRB14 Antibody, Biotin conjugated

  • 中文名稱:
    GRB14兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA009888LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GRB14 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GRB14
  • 別名:
    GRB14Growth factor receptor-bound protein 14 antibody; GRB14 adapter protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Growth factor receptor-bound protein 14 protein (294-397AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
  • 基因功能參考文獻:
    1. We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin sensitivity. PMID: 27281273
    2. The N-terminus of the BPS domain plays an important role in the regulation of human Grb14 and insulin receptor complex formation through phosphorylation, in addition to other domains. PMID: 28130417
    3. Colorectal cancer patients with high GRB14 levels had a shorter survival and GRB14 was upregulated at an advanced clinical stage with enhanced tumor invasion and lymph node metastasis. PMID: 26965150
    4. Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor. PMID: 24535599
    5. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3, GRB14 PMID: 23670221
    6. Modulation of mouse rod photoreceptor responses by Grb14 protein. PMID: 24273167
    7. ANKRD55 rs459193 and GRB14 rs13389219 associate with insulin resistance. PMID: 23457408
    8. Grb14 is the first negative regulator of CEACAM3-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact PMID: 22948154
    9. A new role for Grb14 in finely tuning receptor signaling and modulating thyroid cancer progression. PMID: 22158039
    10. serves as an adaptor protein to recruit 3-phosphoinositede-dependent kinase-1 to activated insulin receptor, thus promoting Akt phosphorylation and transduction of the insulin signal PMID: 15210700
    11. regulation of Grb14 expression levels in response to hormonal stimuli, and are consistent with its role as a repressor of insulin signaling where it is induced as a negative feedback mechanism. PMID: 15372466
    12. Grb14 may regulate signalling through the insulin receptor by controlling its tyrosine dephosphorylation in a site-specific manner. PMID: 16582879
    13. GRB14 is a weight-loss-responsive gene in skeletal muscle. Its observed transcriptional modulation may improve insulin signaling, with weight loss. PMID: 16849634
    14. Grb14 regulates insulin action at two levels, through insulin receptors binding and by interfering with downstream pathways. PMID: 19359342

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Endosome membrane; Peripheral membrane protein.
  • 蛋白家族:
    GRB7/10/14 family
  • 組織特異性:
    Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4565

    OMIM: 601524

    KEGG: hsa:2888

    STRING: 9606.ENSP00000263915

    UniGene: Hs.411881



主站蜘蛛池模板: 国产麻豆剧果冻传媒白晶晶| 日韩高清在线亚洲专区小说| 无码伊人66久久大杳蕉网站谷歌| 欧美性色黄大片| 超清中文乱码字幕在线观看 | 日韩欧美精品有码在线| 亚洲男人第一av网站| 国产99久久久国产精品~~牛| 欧美尺码专线欧洲b1b1| 成人影院永久免费观看网址| 色欲av亚洲一区无码少妇| 色综合中文综合网| 中文乱码人妻系列一区| 免费人成黄页在线观看国产| 色88久久久久高潮综合影院| h肉动漫无码无修6080动漫网 | 无尺码精品产品日韩| 人妻中文字幕无码系列| 在线播放亚洲人成电影| 蜜臀精品无码av在线播放| 欧美日韩精品久久久免费观看| 国产精品女同一区二区在线| 国产精品人妻一区二区高| 久久久无码一区二区三区| 亚洲性色av一区二区三区| 国产精品成人观看视频国产奇米| 朝鲜女人大白屁股ass孕交| 一本色道久久88综合日韩精品| 日日碰狠狠躁久久躁96| 欧美 日韩 亚洲 精品二区| 唐人社导航福利精品| 性欧美牲交在线视频| 国产成人av性色在线影院色戒| 久久人妻av中文字幕| 亚洲中文字幕无码av| 国产亚洲aⅴ在线电影| av小次郎收藏| 精品人妻一区二区三区四区| 好日子在线观看视频大全免费动漫| 少妇激情艳情综合小视频| 男人扒女人添高潮视频|