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GPX2 Antibody

  • 中文名稱:
    GPX2兔多克隆抗體
  • 貨號:
    CSB-PA009867LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunofluorescent analysis of HepG2 cells using CSB-PA009867LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GPX2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Gastrointestinal glutathione peroxidase antibody; GI GPx antibody; Glutathione peroxidase 2 (gastrointestinal) antibody; Glutathione peroxidase 2 antibody; Glutathione peroxidase gastrointestinal antibody; Glutathione peroxidase related protein 2 antibody; Glutathione peroxidase-gastrointestinal antibody; Glutathione peroxidase-related protein 2 antibody; GPRP antibody; GPRP-2 antibody; GPx 2 antibody; GPx-2 antibody; GPx-GI antibody; GPX2 antibody; GPX2_HUMAN antibody; GSHPx 2 antibody; GSHPx GI antibody; GSHPx-2 antibody; GSHPx-GI antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Glutathione peroxidase 2 protein (71-168AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,GPX2 Antibody (CSB-PA009867LA01HU),的標記方式是Non-conjugated。對于GPX2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA009867LB01HU GPX2 Antibody, HRP conjugated ELISA
    FITC CSB-PA009867LC01HU GPX2 Antibody, FITC conjugated
    Biotin CSB-PA009867LD01HU GPX2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
  • 基因功能參考文獻:
    1. GPx2 may play an important role in the development of nasopharyngeal carcinoma. Furthermore, GPx2 may serve as a prognostic biomarker for NPC patient. PMID: 28453466
    2. Yes associated protein 1 (YAP) activation led to excessive accumulation of reactive oxygen species (ROS) by downregulating the antioxidant enzyme glutathione peroxidase GPX2 in a manner related to tumor protein p63 blockade. PMID: 28916653
    3. Results showed that the expression of GPX2 was significantly up-regulated within esophageal squamous cell carcinoma tissues. PMID: 27388201
    4. Glutathione peroxidase 2 expression is a novel independent prognostic biomarker for gastric carcinoma that may be used to devise personalized therapeutic regimens and precision treatments for this disease PMID: 28631563
    5. glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients. PMID: 28635398
    6. Cardamonin exposure and selenium availability regulate expression of HO-1, GPX2 and TrxR1 in human intestinal cells. PMID: 26698667
    7. GPX2 underexpression is associated with advanced tumor status and implicated unfavorable clinical outcome of UCs, suggesting its role in tumor progression and may serve as a theranostic biomarker of UCs. PMID: 25813210
    8. high GPx2 expression was associated with early tumor recurrence, particularly in the recently identified aggressive subtype of human colon cancer. PMID: 25261240
    9. Patients with high GPX2 expression in biopsy specimen had significantly lower prostate-specific antigen recurrence-free survival and overall survival than those with no GPX2 expression. PMID: 24562575
    10. miR-185 plays a role in up-regulation of GPX2 and SEPHS2 expression. PMID: 23934683
    11. A role of GPx2, TrxR2 and TrxR3 in proliferation, apoptosis and, therefore, also during cancer development. PMID: 22683372
    12. A GPx2-independent decrease in tumor development by selenium (Se) and detrimental effects of the Nrf2-activator sulforaphane in moderate Se deficiency. PMID: 22758632
    13. Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue PMID: 11811519
    14. Data suggest that some antioxidants may exert their anti-inflammatory and anticarcinogenic effects not only by induction of phase 2 enzymes but also by the up-regulation of the selenoprotein GI-GPx by Nrf2 binding. PMID: 15923610
    15. some isoforms of p63 serve as a pro-survival factor by up-regulating GPX2 to reduce the p53-dependent oxidative stress-induced apoptotic response PMID: 16446369
    16. Glutathione peroxidase 2 (GPX2) is the major oxidative stress-inducible cellular GPX isoform in the lungs, and its basal as well as inducible expression is dependent on Nrf2. PMID: 16794261
    17. SNPs involving the GSTP1, MnSOD and GPX2 genes were not associated with Barrett's esophagus or esophageal adenocarcinoma PMID: 17277236
    18. Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin. PMID: 17937616
    19. Gpx2 is an overexpressed gene in human breast cancers PMID: 18056462
    20. Results show that GPx2 by compartmentalized removal of hydroperoxides silences COX-2 activity and suppresses PGE(2)-dependent COX-2 and mPGES-1 expression. PMID: 18479189
    21. No significant risk for GPX2 in colorectal adenoma. PMID: 18483336
    22. Data show that GPx2 inhibits malignant characteristics of tumor cells, migration and invasion, obviously by counteracting COX-2 expression but is required for the growth of transformed intestinal cells and may, therefore, facilitate tumor cell growth. PMID: 19047153
    23. Knockout studies in mice suggest that Gpx2 mRNA and GPX-2 activity levels are induced by luminal microflora, consistent with a role in suppression of inflammation in the mucosal epithelium during weaning. PMID: 12751789

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  • 亞細胞定位:
    Cytoplasm. Note=Mainly cytoplasmic.
  • 蛋白家族:
    Glutathione peroxidase family
  • 組織特異性:
    Mostly in liver and gastrointestinal tract, not found in heart or kidney.
  • 數據庫鏈接:

    HGNC: 4554

    OMIM: 138319

    KEGG: hsa:2877

    STRING: 9606.ENSP00000374265

    UniGene: Hs.2704



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