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  4. Human Glutathione peroxidase 2(GPX2) ELISA kit

Human Glutathione peroxidase 2(GPX2) ELISA kit

  • 中文名稱：
    人谷胱甘肽過氧化物酶(GPX2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL009867HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人谷胱甘肽過氧化物酶(GPX2)酶聯(lián)免疫試劑盒（CSB-EL009867HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的GPX2含量。GPX2（谷胱甘肽過氧化物酶2）是一種抗氧化酶，主要在胃腸道、肝臟和乳腺組織中表達(dá)，參與催化還原脂氫過氧化物和過氧化氫，保護(hù)細(xì)胞免受氧化損傷。研究顯示，GPX2在多種癌癥中表達(dá)上調(diào)，與腫瘤的侵襲、轉(zhuǎn)移和預(yù)后相關(guān)，其敲低可增加細(xì)胞對凋亡的敏感性，為肝癌等癌癥的治療提供了新的靶點。試劑盒檢測范圍為25 pg/mL-1600 pg/mL，適用于科研領(lǐng)域?qū)ρ趸瘧?yīng)激相關(guān)機(jī)制的研究；為探索其在消化道疾病、癌癥進(jìn)展或抗氧化防御中的生物學(xué)功能提供可靠工具，尤其適用于體外模型中氧化損傷評估、藥物干預(yù)效果分析及相關(guān)信號通路機(jī)制研究本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Gastrointestinal glutathione peroxidase ELISA Kit; GI GPx ELISA Kit; Glutathione peroxidase 2 (gastrointestinal) ELISA Kit; Glutathione peroxidase 2 ELISA Kit; Glutathione peroxidase gastrointestinal ELISA Kit; Glutathione peroxidase related protein 2 ELISA Kit; Glutathione peroxidase-gastrointestinal ELISA Kit; Glutathione peroxidase-related protein 2 ELISA Kit; GPRP ELISA Kit; GPRP-2 ELISA Kit; GPx 2 ELISA Kit; GPx-2 ELISA Kit; GPx-GI ELISA Kit; GPX2 ELISA Kit; GPX2_HUMAN ELISA Kit; GSHPx 2 ELISA Kit; GSHPx GI ELISA Kit; GSHPx-2 ELISA Kit; GSHPx-GI ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    25 pg/mL-1600 pg/mL
  • 靈敏度：
    6.25 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Metabolism
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human GPX2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %91
    Range %86-95
    1:2Average %102
    Range %97-106
    1:4Average %91
    Range %85-95
    1:8Average %98
    Range %91-101
  • 回收率：
    The recovery of human GPX2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9589-98
    EDTA plasma (n=4)8681-89
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    16001.958 1.912 1.935 1.779
    8001.325 1.276 1.301 1.145
    4000.945 0.963 0.954 0.798
    2000.714 0.702 0.708 0.552
    1000.434 0.442 0.438 0.282
    500.367 0.353 0.360 0.204
    250.257 0.248 0.253 0.097
    00.157 0.155 0.156
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
  • 基因功能參考文獻(xiàn)：
    1. GPx2 may play an important role in the development of nasopharyngeal carcinoma. Furthermore, GPx2 may serve as a prognostic biomarker for NPC patient. PMID: 28453466
    2. Yes associated protein 1 (YAP) activation led to excessive accumulation of reactive oxygen species (ROS) by downregulating the antioxidant enzyme glutathione peroxidase GPX2 in a manner related to tumor protein p63 blockade. PMID: 28916653
    3. Results showed that the expression of GPX2 was significantly up-regulated within esophageal squamous cell carcinoma tissues. PMID: 27388201
    4. Glutathione peroxidase 2 expression is a novel independent prognostic biomarker for gastric carcinoma that may be used to devise personalized therapeutic regimens and precision treatments for this disease PMID: 28631563
    5. glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients. PMID: 28635398
    6. Cardamonin exposure and selenium availability regulate expression of HO-1, GPX2 and TrxR1 in human intestinal cells. PMID: 26698667
    7. GPX2 underexpression is associated with advanced tumor status and implicated unfavorable clinical outcome of UCs, suggesting its role in tumor progression and may serve as a theranostic biomarker of UCs. PMID: 25813210
    8. high GPx2 expression was associated with early tumor recurrence, particularly in the recently identified aggressive subtype of human colon cancer. PMID: 25261240
    9. Patients with high GPX2 expression in biopsy specimen had significantly lower prostate-specific antigen recurrence-free survival and overall survival than those with no GPX2 expression. PMID: 24562575
    10. miR-185 plays a role in up-regulation of GPX2 and SEPHS2 expression. PMID: 23934683
    11. A role of GPx2, TrxR2 and TrxR3 in proliferation, apoptosis and, therefore, also during cancer development. PMID: 22683372
    12. A GPx2-independent decrease in tumor development by selenium (Se) and detrimental effects of the Nrf2-activator sulforaphane in moderate Se deficiency. PMID: 22758632
    13. Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue PMID: 11811519
    14. Data suggest that some antioxidants may exert their anti-inflammatory and anticarcinogenic effects not only by induction of phase 2 enzymes but also by the up-regulation of the selenoprotein GI-GPx by Nrf2 binding. PMID: 15923610
    15. some isoforms of p63 serve as a pro-survival factor by up-regulating GPX2 to reduce the p53-dependent oxidative stress-induced apoptotic response PMID: 16446369
    16. Glutathione peroxidase 2 (GPX2) is the major oxidative stress-inducible cellular GPX isoform in the lungs, and its basal as well as inducible expression is dependent on Nrf2. PMID: 16794261
    17. SNPs involving the GSTP1, MnSOD and GPX2 genes were not associated with Barrett's esophagus or esophageal adenocarcinoma PMID: 17277236
    18. Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin. PMID: 17937616
    19. Gpx2 is an overexpressed gene in human breast cancers PMID: 18056462
    20. Results show that GPx2 by compartmentalized removal of hydroperoxides silences COX-2 activity and suppresses PGE(2)-dependent COX-2 and mPGES-1 expression. PMID: 18479189
    21. No significant risk for GPX2 in colorectal adenoma. PMID: 18483336
    22. Data show that GPx2 inhibits malignant characteristics of tumor cells, migration and invasion, obviously by counteracting COX-2 expression but is required for the growth of transformed intestinal cells and may, therefore, facilitate tumor cell growth. PMID: 19047153
    23. Knockout studies in mice suggest that Gpx2 mRNA and GPX-2 activity levels are induced by luminal microflora, consistent with a role in suppression of inflammation in the mucosal epithelium during weaning. PMID: 12751789

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  • 亞細(xì)胞定位：
    Cytoplasm. Note=Mainly cytoplasmic.
  • 蛋白家族：
    Glutathione peroxidase family
  • 組織特異性：
    Mostly in liver and gastrointestinal tract, not found in heart or kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4554

    OMIM: 138319

    KEGG: hsa:2877

    STRING: 9606.ENSP00000374265

    UniGene: Hs.2704



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