在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GPS1 Antibody

GPS1 Antibody

  • 中文名稱：
    GPS1兔多克隆抗體
  • 貨號：
    CSB-PA009858GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    GPS1
  • 別名：
    COP9 signalosome complex subunit 1 antibody; COP9 signalosome subunit 1 antibody; COPS1 antibody; CSN 1 antibody; CSN1_HUMAN antibody; FUS6/COP11; Arabidopsis; homolog of antibody; G protein pathway suppressor 1 antibody; GPS-1 antibody; Gps1 antibody; JAB1-containing signalosome subunit 1 antibody; Protein GPS1 antibody; Protein MFH antibody; SGN1 antibody; Signalosome subunit 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human GPS1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
  • 基因功能參考文獻：
    1. CSN1 appears to play a role not only in DNA repair but also in UV-induced apoptosis. PMID: 26986008
    2. We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells. PMID: 23408908
    3. An increased level of CSN1 and CSN5 as an important part of the ubiquitin proteasome system (UPS) might be associated with the pathophysiology of preeclampsia. PMID: 22103747
    4. CSN1 inhibits c-Jun phosphorylation without affecting its protein stability. PMID: 21604193
    5. The N-terminal half of CSN1/GPS1 is required to repress c-fos expression and to inhibit AP-1 and SRE transactivation, while the C-terminal half allows integration of the protein into the COP9 signalosome. PMID: 11114242

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN1 family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 4549

    OMIM: 601934

    KEGG: hsa:2873

    STRING: 9606.ENSP00000347251

    UniGene: Hs.268530



主站蜘蛛池模板： 无码免费一区二区三区| 寂寞骚妇被后入式爆草抓爆 | 欧美va亚洲va在线观看日本| 国产日产精品久久快鸭的功能介绍| 欧美一区二区三区性视频| 13小箩利洗澡无码视频网站| 少妇又紧又深又湿又爽视频| 日日碰狠狠躁久久躁蜜桃| 7878成人国产在线观看| 天堂网www天堂资源网| 日韩精品射精管理在线观看| 搡老岳熟女国产熟妇| 免费刺激性视频大片区| 欧美激性欧美激情在线| 国产精品青草久久福利不卡| 五月丁香六月综合av| 亚洲最大的成人网站| 亚洲女人色综合小说| 亚洲理论电影在线观看| 国产精品久久国产精品99 gif| 88久久精品无码一区二区毛片| 国产亚洲综合欧美视频| 大香伊人久久精品一区二区| 欧美日本国产va高清cabal | 亚洲精品一区二区三区新线路 | 亚洲精品成a人在线观看| 人妻体内射精一区二区| 亚洲欧美日本久久综合网站点击| 亚洲中文字幕无码天然素人| 久久婷婷是五月综合色| 色偷偷亚洲男人本色| 亚洲精品无码mⅴ在线观看| 西西人体大胆无码视频| 国产亚洲精品久久无码98| 国产色xx群视频射精| 一本色道无码道在线观看| 少妇高潮惨叫久久久久电影| 99久久人人爽亚洲精品美女 | 亚洲一区二区三区香蕉| 久久久久日韩精品免费观看| 欧美性大战xxxxx久久久√|