在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GPS1 Antibody

GPS1 Antibody

  • 中文名稱：
    GPS1兔多克隆抗體
  • 貨號：
    CSB-PA009858GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    GPS1
  • 別名：
    COP9 signalosome complex subunit 1 antibody; COP9 signalosome subunit 1 antibody; COPS1 antibody; CSN 1 antibody; CSN1_HUMAN antibody; FUS6/COP11; Arabidopsis; homolog of antibody; G protein pathway suppressor 1 antibody; GPS-1 antibody; Gps1 antibody; JAB1-containing signalosome subunit 1 antibody; Protein GPS1 antibody; Protein MFH antibody; SGN1 antibody; Signalosome subunit 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human GPS1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
  • 基因功能參考文獻：
    1. CSN1 appears to play a role not only in DNA repair but also in UV-induced apoptosis. PMID: 26986008
    2. We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells. PMID: 23408908
    3. An increased level of CSN1 and CSN5 as an important part of the ubiquitin proteasome system (UPS) might be associated with the pathophysiology of preeclampsia. PMID: 22103747
    4. CSN1 inhibits c-Jun phosphorylation without affecting its protein stability. PMID: 21604193
    5. The N-terminal half of CSN1/GPS1 is required to repress c-fos expression and to inhibit AP-1 and SRE transactivation, while the C-terminal half allows integration of the protein into the COP9 signalosome. PMID: 11114242

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN1 family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 4549

    OMIM: 601934

    KEGG: hsa:2873

    STRING: 9606.ENSP00000347251

    UniGene: Hs.268530



主站蜘蛛池模板： 人妻巨大乳挤奶水hd免费看| 国产午夜亚洲精品不卡在线观看| 无码日韩精品一区二区人妻| 99e久热只有精品8在线直播| 国产线观看免费观看| 无码纯肉动漫在线观看| 人妻互换一二三区激情视频| 中日av乱码一区二区三区乱码| 亚洲综合色丁香婷婷六月图片| 久久无码无码久久综合综合| 国产真实露脸乱子伦| 少妇粉嫩小泬白浆流出| 女人18毛片水最多| 国产毛片一区二区精品| 一区二区三区国产精华液| 国产日韩成人内射视频| 久久综合久久美利坚合众国| 强制高潮18xxxx按摩| 亚洲精品国产高清一线久久| 日本护士毛茸茸| 欧美成人一区二区三区在线视频 | 亚洲人成在线观看| 一区二区三区四区在线 | 中国| 美女黄网站18禁免费看| 极品美女扒开粉嫩小泬| 国产精品亚洲欧美大片在线看| 国产亚洲人成在线播放| 免费观看男女性高视频| 人人爽天天碰天天躁夜夜躁| 人妻人人做人做人人爱| 尤物193在线人妻精品免费| 欧美成人高清视频a在线看| 在线欧美中文字幕农村电影| 超碰色偷偷男人的天堂| 国产精品人成在线播放新网站| 美国一区二区三区无码视频| 欧美日韩在线视频| 少妇内射兰兰久久| 国产精品毛片在线完整版| 久久97久久97精品免视看| 夜夜影院未满十八勿进|