在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GPS1 Antibody

GPS1 Antibody

  • 中文名稱：
    GPS1兔多克隆抗體
  • 貨號：
    CSB-PA615663ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: GPS1 antibody at 5µg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 56, 60 kDa
      Observed band size: 56 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA615663ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA615663ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GPS1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GPS1
  • 別名：
    COP9 signalosome complex subunit 1 antibody; COP9 signalosome subunit 1 antibody; COPS1 antibody; CSN 1 antibody; CSN1_HUMAN antibody; FUS6/COP11; Arabidopsis; homolog of antibody; G protein pathway suppressor 1 antibody; GPS-1 antibody; Gps1 antibody; JAB1-containing signalosome subunit 1 antibody; Protein GPS1 antibody; Protein MFH antibody; SGN1 antibody; Signalosome subunit 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human COP9 signalosome complex subunit 1 protein (222-491AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
  • 基因功能參考文獻：
    1. CSN1 appears to play a role not only in DNA repair but also in UV-induced apoptosis. PMID: 26986008
    2. We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells. PMID: 23408908
    3. An increased level of CSN1 and CSN5 as an important part of the ubiquitin proteasome system (UPS) might be associated with the pathophysiology of preeclampsia. PMID: 22103747
    4. CSN1 inhibits c-Jun phosphorylation without affecting its protein stability. PMID: 21604193
    5. The N-terminal half of CSN1/GPS1 is required to repress c-fos expression and to inhibit AP-1 and SRE transactivation, while the C-terminal half allows integration of the protein into the COP9 signalosome. PMID: 11114242

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN1 family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4549

    OMIM: 601934

    KEGG: hsa:2873

    STRING: 9606.ENSP00000347251

    UniGene: Hs.268530



主站蜘蛛池模板： 日产精品99久久久久久| 在线日韩av免费永久观看 | 少妇无码av无码一区| 精品无码国产日韩制服丝袜 | 学生妹无套内射正在播放| 激情无码人妻又粗又大中国人 | 少妇人妻综合久久中文| 亚洲精品久久久久avwww潮水| 国产成人一区二区三区| 国产成人av大片大片在线播放| 国产午夜亚洲精品不卡| 天天做天天爱天天要天天 | 国产精品99久久久久久久女警| 国产成人精品日本亚洲第一区| 老子影院午夜精品无码| 久久无码潮喷a片无码高潮| 国产精品亚洲专区无码老司国| 性暴力欧美猛交在线播放| 最新高清无码专区| 国产毛a片啊久久久久久保和丸| 久艹视频免费看| 国产精品白丝喷浆| 无码午夜人妻一区二区三区不卡视频| 亚洲欧洲日产国码无码久久99| 女人被做到高潮免费视频| 色天使亚洲综合一区二区| 国产乱人伦av在线a最新| 无码人妻丰满熟妇奶水区码| 国产成人无码18禁午夜福利p| 日韩精品无码专区免费视频| 99久久婷婷国产一区二区| 护士人妻hd中文字幕| 国产偷人妻精品一区| 亚洲午夜无码久久yy6080| 国产亚洲欧洲aⅴ综合一区| 亚洲精品无码一区二区| 无遮挡aaaaa大片免费看| 日日摸日日碰夜夜爽免费| 国产精品人妻一码二码| 色狠狠成人综合网| 成a人片亚洲日本久久|