在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GPR68 Antibody

  • 中文名稱:
    GPR68兔多克隆抗體
  • 貨號:
    CSB-PA623012ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA623012ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA623012ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GPR68 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    GPR68; OGR1; Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ovarian cancer G-protein coupled receptor 1 protein (276-365AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer.
  • 基因功能參考文獻:
    1. High GPR68 expression is associated with pancreatic ductal adenocarcinoma. PMID: 29092903
    2. different benzodiazepines exhibit a range of biases for OGR1, with sulazepam selectively activating the canonical Gs of the G protein signaling pathway, in heterologous expression systems, as well as in several primary cell types. PMID: 29042451
    3. Our results suggest that OGR1-dependent increases in TRPC4 expression may favour formation of highly Ca(2+) -permeable TRPC4-containing channels that promote transformed granule cell migration. Increased motility of cancer cells is a prerequisite for cancer invasion and metastasis, and our findings may point towards a key role for TRPC4 in progression of certain types of medullablastoma. PMID: 28627017
    4. Blocking of GPR68 or NF-small ka, CyrillicB activity severely attenuated acidification induced IL-8 production. PMID: 27166427
    5. These results suggest that zOGR1, but not GPR4, is also a metal-sensing G-protein-coupled receptor in addition to a proton-sensing G-protein-coupled receptor, although not all metals that activate hOGR1 activated zOGR1. PMID: 28270026
    6. data identify a role for GPR68 as a proton sensor that is required for proper enamel formation PMID: 27693231
    7. coexpression of OGR1- and G2A-enhanced proton sensitivity and proton-induced calcium signals. This alteration is attributed to oligomerization of OGR1 and G2A. The oligomeric potential locates receptors at a specific site, which leads to enhanced PMID: 27049592
    8. Proton-sensing GPCR-YAP Signalling Promotes Cancer-associated Fibroblast Activation of Mesenchymal Stem Cells PMID: 27019624
    9. The deconstruction of OGR1-dependent signaling may aid our understanding of mucosal inflammation mechanisms PMID: 26206859
    10. Provide evidence for the roles of OGR1 and ASIC1a in the regulation of intestinal passive Mg(2+) absorption. PMID: 24375028
    11. the expression of OGR1 in myeloid-derived cells, especially in double positive cells, was required for prostate tumor cell-induced immunosuppression. PMID: 23222714
    12. The involvement of ovarian cancer G-protein-coupled receptor 1 in acidic extracellular environment may be an underlying mechanism responsible for bone pain in osteoporosis or bone metastasis without clinically proved fractures. PMID: 22835475
    13. OGR1 activation increased intracellular calcium in transfected HEK293 cells. PMID: 22508039
    14. It indicated that OGR1 may be a tumor suppressor gene for ovarian cancer. PMID: 21740742
    15. extracellular acidification induces CTGF production through the OGR1/G(q/11) protein and inositol-1,4,5-trisphosphate-induced Ca(2+) mobilization in human airway smooth muscle cells. PMID: 21907704
    16. acidic pH-induced vascular actions of aortic smooth muscle cells can be dissected to OGR1-dependent and -independent pathways: COX-2 expression, PGI(2) production, and MKP-1 expression are mediated by OGR1, but PAI-1 expression is not. PMID: 20622109
    17. ovarian cancer G-protein-coupled receptor 1 (OGR1), previously described as a receptor for sphingosylphosphorylcholine, acts as a proton-sensing receptor stimulating inositol phosphate formation PMID: 12955148
    18. OGR1 was found to evoke strong pH-dependent responses as measured by inositol phosphate accumulation. PMID: 15665078
    19. cAMP accumulation may occur through OGR1-mediated stimulation of the phospholipase C/cyclooxygenase/PGI(2) pathway PMID: 16087674
    20. OGR1 is a novel metastasis suppressor gene for prostate cancer. OGR1's constitutive activity via G alpha(i) contributes to its inhibitory effect on cell migration in vitro. PMID: 17728215
    21. OGR1/G(q/11)/phospholipase C/protein kinase C pathway regulates osteoblastic COX-2 induction and subsequent PGE(2) production in response to acidic circumstances PMID: 18302504

    顯示更多

    收起更多

  • 相關疾病:
    Amelogenesis imperfecta, hypomaturation type, 2A6 (AI2A6)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.
  • 數據庫鏈接:

    HGNC: 4519

    OMIM: 601404

    KEGG: hsa:8111

    STRING: 9606.ENSP00000434045

    UniGene: Hs.8882



主站蜘蛛池模板: 国产精品一国产精品| 午夜理论片yy6080私人影院| 少妇饥渴xxhd麻豆xxhd骆驼| 亚洲精品久久午夜无码一区二区| 国产精品美女久久久久久2021| 动漫无遮挡h纯肉亚洲资源大片| 黑人巨大精品欧美一区二区| 丝袜人妻一区二区三区| 十八禁啪啪无遮挡网站| 乱人伦中文无码视频| 一本一道久久综合狠狠老| 亚洲 自拍 另类小说综合图区| 色偷偷尼玛图亚洲综合| 狠狠色噜噜狠狠狠狠五月婷| 免费99精品国产自在在线| 成人亚洲精品久久久久| 日韩高清在线亚洲专区小说| 亚洲成a人无码| 一区二区乱子伦在线播放| 免费国产h视频在线观看| 国内精品一区二区三区不卡| 97人妻天天摸天天爽天天| 爱性久久久久久久久| 久久人妻国产精品| 曰批全过程免费视频在线观看无码| 麻豆高清免费国产一区| 精品熟女少妇a∨免费久久| 欧美裸体xxxx极品| 五月婷婷久久草丁香| 98国产精品综合一区二区三区| 丰满少妇大叫太大太粗| 国产精品成人午夜久久| 无套内射在线无码播放| 亚洲va无码va在线va天堂| 国产超碰人人做人人爱| 熟女性饥渴一区二区三区| 波多野结衣aⅴ在线| aaa欧美色吧激情视频| 日本中文字幕乱码免费| 欧美大屁股xxxx高跟欧美黑人| 亚洲性无码av在线|