在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GPR68 Antibody

  • 中文名稱:
    GPR68兔多克隆抗體
  • 貨號:
    CSB-PA060199
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    GPR68; OGR1; Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human GPR68.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

產品評價

靶點詳情

  • 功能:
    Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer.
  • 基因功能參考文獻:
    1. High GPR68 expression is associated with pancreatic ductal adenocarcinoma. PMID: 29092903
    2. different benzodiazepines exhibit a range of biases for OGR1, with sulazepam selectively activating the canonical Gs of the G protein signaling pathway, in heterologous expression systems, as well as in several primary cell types. PMID: 29042451
    3. Our results suggest that OGR1-dependent increases in TRPC4 expression may favour formation of highly Ca(2+) -permeable TRPC4-containing channels that promote transformed granule cell migration. Increased motility of cancer cells is a prerequisite for cancer invasion and metastasis, and our findings may point towards a key role for TRPC4 in progression of certain types of medullablastoma. PMID: 28627017
    4. Blocking of GPR68 or NF-small ka, CyrillicB activity severely attenuated acidification induced IL-8 production. PMID: 27166427
    5. These results suggest that zOGR1, but not GPR4, is also a metal-sensing G-protein-coupled receptor in addition to a proton-sensing G-protein-coupled receptor, although not all metals that activate hOGR1 activated zOGR1. PMID: 28270026
    6. data identify a role for GPR68 as a proton sensor that is required for proper enamel formation PMID: 27693231
    7. coexpression of OGR1- and G2A-enhanced proton sensitivity and proton-induced calcium signals. This alteration is attributed to oligomerization of OGR1 and G2A. The oligomeric potential locates receptors at a specific site, which leads to enhanced PMID: 27049592
    8. Proton-sensing GPCR-YAP Signalling Promotes Cancer-associated Fibroblast Activation of Mesenchymal Stem Cells PMID: 27019624
    9. The deconstruction of OGR1-dependent signaling may aid our understanding of mucosal inflammation mechanisms PMID: 26206859
    10. Provide evidence for the roles of OGR1 and ASIC1a in the regulation of intestinal passive Mg(2+) absorption. PMID: 24375028
    11. the expression of OGR1 in myeloid-derived cells, especially in double positive cells, was required for prostate tumor cell-induced immunosuppression. PMID: 23222714
    12. The involvement of ovarian cancer G-protein-coupled receptor 1 in acidic extracellular environment may be an underlying mechanism responsible for bone pain in osteoporosis or bone metastasis without clinically proved fractures. PMID: 22835475
    13. OGR1 activation increased intracellular calcium in transfected HEK293 cells. PMID: 22508039
    14. It indicated that OGR1 may be a tumor suppressor gene for ovarian cancer. PMID: 21740742
    15. extracellular acidification induces CTGF production through the OGR1/G(q/11) protein and inositol-1,4,5-trisphosphate-induced Ca(2+) mobilization in human airway smooth muscle cells. PMID: 21907704
    16. acidic pH-induced vascular actions of aortic smooth muscle cells can be dissected to OGR1-dependent and -independent pathways: COX-2 expression, PGI(2) production, and MKP-1 expression are mediated by OGR1, but PAI-1 expression is not. PMID: 20622109
    17. ovarian cancer G-protein-coupled receptor 1 (OGR1), previously described as a receptor for sphingosylphosphorylcholine, acts as a proton-sensing receptor stimulating inositol phosphate formation PMID: 12955148
    18. OGR1 was found to evoke strong pH-dependent responses as measured by inositol phosphate accumulation. PMID: 15665078
    19. cAMP accumulation may occur through OGR1-mediated stimulation of the phospholipase C/cyclooxygenase/PGI(2) pathway PMID: 16087674
    20. OGR1 is a novel metastasis suppressor gene for prostate cancer. OGR1's constitutive activity via G alpha(i) contributes to its inhibitory effect on cell migration in vitro. PMID: 17728215
    21. OGR1/G(q/11)/phospholipase C/protein kinase C pathway regulates osteoblastic COX-2 induction and subsequent PGE(2) production in response to acidic circumstances PMID: 18302504

    顯示更多

    收起更多

  • 相關疾病:
    Amelogenesis imperfecta, hypomaturation type, 2A6 (AI2A6)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.
  • 數據庫鏈接:

    HGNC: 4519

    OMIM: 601404

    KEGG: hsa:8111

    STRING: 9606.ENSP00000434045

    UniGene: Hs.8882



主站蜘蛛池模板: 亚洲 欧美 中文 在线 视频 | 3d动漫精品啪啪一区二区| 日本免费人成视频播放| 国产mv在线天堂mv免费观看| 国产亚洲产品影视在线产品| 玩肥熟老妇bbw视频| 久久视热这里只有精品| 亚洲欭美日韩颜射在线| 狠狠人妻久久久久久综合蜜桃 | 日本无翼乌邪恶大全彩h| 天天碰免费上传视频| 久久精品亚洲乱码伦伦中文| 久久精品人人做人人爱爱漫画 | 久久综合九色综合久99| 人妻少妇69式99偷拍| 色先锋资源久久综合5566| 亚在线第一国产州精品99| 人人莫人人擦人人看| 亚洲人成人网站在线观看| av在线观看地址| 无码精品国产一区二区三区免费| 亚洲人成77777在线播放网站| 久久精品国产成人午夜福利| 伊人久久大香线蕉av五月天宝贝| 欧美成人在线视频| 欧美性猛交xxxx黑人| 非洲黑人性xxxx精品| 男女一边摸一边做爽爽的免费阅读| 亚洲爆乳少妇无码激情| 国产高清av首播原创麻豆| 中文字幕久久综合伊人| 国产三级精品三级在线专1| 大又大又粗又硬又爽少妇毛片| 狠狠97人人婷婷五月| 久久视频在线视频| 亚洲人成人无码www| 亚洲国产制服丝袜高清在线| 国产精品一区二区久久国产| 97国产精东麻豆人妻电影 | 亚洲无av码在线中文字幕| 精品国产午夜福利精品推荐|