在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GPR4 Antibody, HRP conjugated

GPR4 Antibody, HRP conjugated

  • 中文名稱：
    GPR4兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA009813LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GPR4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GPR4; G-protein coupled receptor 4; G-protein coupled receptor 6C.l; GPR6C.l
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human G-protein coupled receptor 4 protein (285-362AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2)H(+).
  • 基因功能參考文獻(xiàn)：
    1. Proton-sensing GPR4 signaling mediated the proton-induced inhibitory effects on the osteogenesis of BMSCs. YAP was the downstream effector of GPR4 signaling. Extracellular pH modulates the osteogenic responses of BMSCs by regulating the proton-sensing GPR4-YAP pathway. PMID: 27256071
    2. These results suggest that zOGR1, but not GPR4, is also a metal-sensing G-protein-coupled receptor in addition to a proton-sensing G-protein-coupled receptor, although not all metals that activate hOGR1 activated zOGR1. PMID: 28270026
    3. GPR4 blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression. PMID: 29089376
    4. acidosis/GPR4-induced endoplasmic reticulum stress pathways in endothelial cells may regulate vascular growth and inflammatory response in the acidic microenvironment. PMID: 28134810
    5. it was demonstrated that GPR4 affects ECs by regulating Notch1, a function that may be important for physiological and pathological angiogenesis. PMID: 27279286
    6. GPR4 induces angiogenesis via GPR4-induced p38-mediated IL6, IL8 and VEGFA secretion at acidic extracellular pH in squamous cell carcinoma of the head and neck PMID: 27078157
    7. The results suggested that GPR4 may play an important role in the development of epithelial ovarian carcinoma (EOC), and its overexpression might be required for the angiogenesis, tumor growth, and metastasis of EOC PMID: 23888957
    8. acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/Epac pathway PMID: 22110680
    9. The mutation of histidine residue at 79, 165, or 269 from the N-terminal of GPR4 to phenylalanine shifted the half-maximal effective concentration (EC(50)) of proton-induced signaling activities to the right, including cAMP accumulation. PMID: 20211729
    10. Endogenous GPR4 in endothelial cells may be a potential G protein-coupled receptor by which LPC signals proinflammatory activities. PMID: 12805023
    11. GPR4, a close relative of OGR1, also responds to pH changes, but elicits cyclic AMP formation PMID: 12955148
    12. sphingosylphosphorylcholine and lysophosphatidic acid are not the ligands for GPR4 and that this receptor may constitutively inhibit ERK1/2 activation PMID: 14567679
    13. GPR4 and TDAG8 overexpression in human tumors plays a role in driving or maintaining tumor formation PMID: 15221007
    14. results identify sphingosylphosphorylcholine and its receptor, G protein-coupled receptor 4(GPR4), as critical regulators of the angiogenic potential of endothelial cells PMID: 15857892
    15. GPR4 may play a critical role in the inflammatory responses activated by lysophosphatidylcholine PMID: 16461426
    16. GPR4 in brain endothelial cells regulates monocyte transmigration. PMID: 17364894
    17. lysophosphatidylcholine receptor G protein-coupled receptor 4 (GPK4) was expressed in YPEN-1 cells and triggered the cAMP/protein kinase A/cAMP response element-binding protein pathway, resulting in upregulation of adhesion molecules. PMID: 17437524
    18. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. PMID: 17462861

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4497

    OMIM: 600551

    KEGG: hsa:2828

    STRING: 9606.ENSP00000319744

    UniGene: Hs.17170



主站蜘蛛池模板： 国产在线不卡视频免费视频| 99久久精品国产一区二区| 高潮潮喷奶水飞溅视频无码| 中文无码天天av天天爽| 精品国产欧美一区二区| 三级特黄60分钟在线播放| 成人天堂资源www在线| 日韩人妻无码一区二区三区久久99| 天天狠天天透天干天干| 狠狠色噜噜狠狠狠狠蜜桃| 亚洲中文字幕无码久久2018| 人妻丰满熟妇aⅴ无码| 中文字幕精品一区二区精品| 欧洲女人牲交性开放视频| 东京热无码国产精品| 久久人妻av一区二区软件| 欧美丰满少妇xxxx性| 日本亚洲欧美日韩国产ay| 人妻熟妇乱又伦精品hd| 亚洲欧洲日产国码无码av一| 中文字幕乱码一区av久久| 蜜臀色欲av在线播放国产日韩| 在线亚洲97se亚洲综合在线| 色妺妺在线视频| 国产成人无码国产亚洲| 欧美变态另类牲交| 特级西西人体444www高清大胆| 一边添奶一边添p好爽视频| 亚洲欧美日韩国产综合点击进入| 午夜爱爱爱爱爽爽爽网站| 特级毛片a片久久久久久 | 色拍拍欧美视频在线看| 国产亚洲欧美另类一区二区| 成人无码α片在线观看不卡 | 精品午夜福利无人区乱码一区 | 日韩精品一区二区三区在线观看| 国产色情又大又粗又黄的电影| 国产suv精二区| 国产免费观看久久黄av片| 国精品无码人妻一区二区三区| 成人h动漫无码网站久久|