在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GORASP2 Antibody

  • 中文名稱:
    GORASP2兔多克隆抗體
  • 貨號:
    CSB-PA446729
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells, HepG2 cells, Jurkat cells and LOVO cells, using GORASP2 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GORASP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GORASP2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human GORASP2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA. Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells. Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane.
  • 基因功能參考文獻:
    1. Results demonstrate a critical role for GRASP55 and GRASP65 in maintaining the stacked structure of the Golgi, which is required for accurate posttranslational modifications in the Golgi. Additionally, the GRASP knockout cell lines developed in this study will be useful tools for studying the role of GRASP proteins in other important cellular processes. PMID: 28814501
    2. binding site at the cleft between the PDZ1 and PDZ2 domains of GRASP65 is dominated by hydrophobic interactions with GM130 that are not observed in the GRASP55-Golgin45 complex PMID: 28049725
    3. GRASP55 interacts with CD83 shortly after induction of dendritic cells maturation. PMID: 25701785
    4. Cisternal-specific functions of GRASP65 and GRASP55 in continuity, compartmentalization, and function of the Golgi ribbon. PMID: 24227884
    5. propose that GRASP55/65 are negative regulators of exocytic transport and that this slowdown helps to ensure more complete protein glycosylation in the Golgi stack and proper sorting at the trans-Golgi network PMID: 23552074
    6. GRASP55 may function as an adaptor protein coupling MT1-MMP with furin, thus leading to the activation of the zymogen. PMID: 20608975
    7. These results demonstrate that GRASP55 and GRASP65 stack mammalian Golgi cisternae via a common mechanism. PMID: 20083603
    8. Data demonstrate that both GRASP55 and 65 are needed for the efficient transport to and through the Golgi complex, thus highlighting a novel role for the GRASPs in membrane trafficking. PMID: 19840934
    9. GRASP65 is an important structural component required for maintenance of Golgi apparatus integrity PMID: 11815631
    10. MEK1/ERK regulation of GRASP55-mediated Golgi linking is a control point in cell cycle progression PMID: 18434598
    11. GRASP55 forms an effector complex for the small GTPase rab2, together with a conserved coiled-coil protein golgin-45 (JEM-1). PMID: 11739401

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus membrane; Lipid-anchor. Endoplasmic reticulum membrane. Golgi apparatus.
  • 蛋白家族:
    GORASP family
  • 數據庫鏈接:

    HGNC: 17500

    OMIM: 608693

    KEGG: hsa:26003

    STRING: 9606.ENSP00000234160

    UniGene: Hs.431317



主站蜘蛛池模板: 国产99视频精品免视看9| 国产精品户外野外| 中文字幕无码日韩专区免费| 日本国产网曝视频在线观看| 日本无卡码高清免费v| 亚洲成av人片一区二区梦乃| 亚洲乱亚洲乱妇小说网| 久久精品国产99久久6动漫| 国产亚洲精品自在久久蜜tv | 国产肉体xxxx裸体784大胆| 成人欧美一区二区三区黑人| 最新高清中文字幕免费mv| 亚洲精品第一国产综合国服瑶| 国产草草影院ccyycom| 色狠狠久久av五月综合| 中文字幕在线亚洲二区| 欧美35页视频在线观看| 熟妇人妻一区二区三区四区| 精品久久久久久久久久久国产字幕| 欧美亚洲另类 丝袜综合网| 中国美女牲交视频| 日本免费一区二区三区中文字幕| 国产亚洲日韩在线播放更多| 国产内射在线激情一区| 特黄熟妇丰满人妻无码| 精品久久久久久亚洲综合网| 国产精品主播一区二区三区| 国产 | 欧洲野花视频天堂视频p | 国产精品原创巨作av| 欧美阿v天堂视频在99线| 国产成人夜色高潮福利影视| 亚洲国产精品成人午夜在线观看| 都市激情 在线 亚洲 国产| 精品av中文字幕在线毛片| 极品新婚夜少妇真紧| 免费视频欧美无人区码| 末发育女av片一区二区| 亚洲欧美日韩v在线观看不卡| 久久精品中文字幕无码绿巨人| 国产又黄又爽又色的免费| 一区二区三区在线 | 日本|