在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GLRX2 Antibody

  • 中文名稱:
    GLRX2兔多克隆抗體
  • 貨號:
    CSB-PA009522GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    GLRX2
  • 別名:
    bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2) antibody; bA101E13.1 antibody; CGI133 antibody; Glrx2 antibody; GLRX2_HUMAN antibody; Glutaredoxin-2 antibody; Glutaredoxin-2; mitochondrial antibody; GRX2 antibody; mitochondrial antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human GLRX2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
  • 基因功能參考文獻:
    1. GRX2 is important in the control of cardiac mitochondrial structure and function, and protects against human cardiac pathologies. PMID: 29101900
    2. Study shows that Grx2 detoxifies *NO in mature oligodendrocytes and oligodendroglial precursor cellsvia the formation of dinitrosyl-iron-complexes, inhibiting the formation of harmful peroxynitrite and reducing subsequent oligodendroglial damage. Findings link inorganic biochemistry to neuroinflammation and identify glutaredoxin 2 as a protective factor against neuroinflammation-mediated myelin damage. PMID: 28618115
    3. Grx2 and Trx1 contribute significantly to neuronal integrity and could be clinically relevant in neuronal damage following perinatal asphyxia and other neuronal disorders. PMID: 25735211
    4. These results suggest that Grx2a plays proliferative and anti-apoptotic roles under serum deprivation. PMID: 21735102
    5. Grx2 thiol redox regulation is essential for vertebrate embryonic development PMID: 22139372
    6. Studies indicate that the mechanism of Grx2 protection against H(2)O(2)-induced apoptosis is likely associated with its ability to preserve complex I. PMID: 20547138
    7. results suggest an important role for glutaredoxin 2 in protection and recovery from oxidative stress PMID: 14676218
    8. Grx1 and Grx2 were present in placenta extracts and in cell lysates prepared from tumor cell lines; however, the levels of Grx1 were at least 20 times higher than those of Grx2; Grx2 was not detected in plasma from healthy blood donors PMID: 15184054
    9. Lung cells can synthesize Grx2 mRNA and protein. PMID: 15297967
    10. characterization of Grx2 as an iron-sulfur center-containing member of the thioredoxin fold protein family PMID: 15917333
    11. Grx2 has a novel function as a peroxidase, accepting electrons both from GSH and TR. This unique property may play a role in protecting the mitochondria from oxidative damage. PMID: 17065220
    12. The iron-sulfur cluster is complexed by the two N-terminal active site thiols of two Grx2 monomers and two molecules of glutathione that are bound noncovalently to the proteins and in equilibrium with glutathione in solution. PMID: 17115894
    13. Eficence of an iron-sulfur cluster in which binding of the cluster inactivates the protein by sequestering active site residues and where loss of the cluster through changes in subcellular redox status creates a catalytically active protein. PMID: 17121859
    14. Human Grx2 is found to be a conserved feature within the deuterostomes and appears to be the only additional conserved intramolecular disulfide within the glutaredoxins. PMID: 17546662
    15. Grx2 is constitutively expressed in both neuron and glia in mouse and human brain including the neurons in human substantia nigra. PMID: 17961515
    16. Grx1 and Grx2 exhibit key catalytic similarities, including selectivity for protein-SSG substrates and a nucleophilic, double-displacement, monothiol mechanism exhibiting a strong commitment to catalysis. PMID: 18816065
    17. cluster signal of Grx2 is stable at positive potentials up to 0.5 V but that cluster destruction occurs readily when oxidative pulses in excess of this value are applied PMID: 19292455

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Mitochondrion.; [Isoform 2]: Nucleus.
  • 蛋白家族:
    Glutaredoxin family
  • 組織特異性:
    Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.
  • 數據庫鏈接:

    HGNC: 16065

    OMIM: 606820

    KEGG: hsa:51022

    UniGene: Hs.458283



主站蜘蛛池模板: 少妇久久久久久久久久| 麻豆国产av超爽剧情系列| 大肉大捧一进一出好爽| 精品人体无码一区二区三区| 日本久久高清一区二区三区毛片 | 午夜理论在线观看不卡大地影院| 亚洲亚洲人成无码网www| 国产av一区二区精品久久| 无码av免费一区二区三区| 精品久久久久久无码免费| 久久午夜色播影院| 大伊香蕉精品视频在线| 日本熟妇人妻中出| 国产a三级久久精品| 欧美国产日韩a欧美在线观看| 四虎永久在线精品免费一区二区| 国产精品天干天干有线观看| 久久超碰精品一夜七次郎| 在线 | 国产精品99传媒丿| 天天摸天天做天天爽水多| 欧美在线看片a免费观看| 亚洲国产天堂久久久久久| 久久久99精品成人片中文字幕 | 国产成人午夜福利在线播放| 西欧free性满足hd| 黑人强辱丰满的人妻熟女| 欧美国产综合欧美视频| 天堂8а√中文在线官网| 国产成人高清精品亚洲| 狠狠躁夜夜躁人人爽超碰97香蕉 | 无遮挡很爽很污很黄的网站| 国产精品a无线| 欧美 国产 日产 韩国 在线 | 亚洲成 人 综合 亚洲欧洲| 免费久久99精品国产自在现线| 国产区精品系列在线观看| 国产精品aⅴ视频在线播放| 国产偷窥熟妇高潮呻吟| 久久久无码人妻精品无码| 性av盈盈无码天堂| 色诱视频在线观看|