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  4. GLIS2 Antibody

GLIS2 Antibody

  • 中文名稱：
    GLIS2兔多克隆抗體
  • 貨號：
    CSB-PA861185LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA861185LA01HU diluted at 1:350 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA861185LA01HU at 1:116, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GLIS2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GLIS2
  • 別名：
    FLJ38247 antibody; GLI similar 2 antibody; GLI-similar 2 antibody; GLIS 2 antibody; GLIS family zinc finger 2 antibody; glis2 antibody; GLIS2_HUMAN antibody; Kruppel like zinc finger protein GLIS2 antibody; Neuronal Krueppel-like protein antibody; Zinc finger protein GLIS2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein GLIS2 protein (332-505AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，GLIS2 Antibody (CSB-PA861185LA01HU)，的標記方式是Non-conjugated。對于GLIS2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA861185LB01HU GLIS2 Antibody, HRP conjugated ELISA
    FITC CSB-PA861185LC01HU GLIS2 Antibody, FITC conjugated
    Biotin CSB-PA861185LD01HU GLIS2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation.
  • 基因功能參考文獻：
    1. CBFA2T3-GLIS2 fusion is associated with acute megakaryoblastic leukemia in non-Down syndrome. PMID: 28063190
    2. specific interference with ETO2-GLIS2 oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia. PMID: 28292442
    3. Clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene are poor due to resistance to chemotherapies and SCT. New treatment strategies are necessary. PMID: 27094503
    4. Nephronophthisis 7-related mutation C175R affects both localization and function of GLIS2 protein. PMID: 26374130
    5. Glis2/NPHP7 is extensively modified by post-translational modifications PMID: 26083374
    6. Findings are unprecedented and indicate that the DHH-RHEBL1 fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2-positive childhood AML. PMID: 24127550
    7. BBS11 promotes accumulation of NPHP7, changing the properties of NPHP7. TRIM32 Modulates the Transcriptional Activities of Glis2 PMID: 24500717
    8. Recessive mutation in GLIS2 gene is associated with Caroli disease. PMID: 23559409
    9. Identification of a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of pediatric acute megakaryoblastic leukemia cases, which encodes a CBFA2T3-GLIS2 fusion protein. PMID: 23153540
    10. Glis2 can function as a transcriptional activator and that post-translational modification within its DNA-binding domain can regulate its transcriptional activity PMID: 21127075
    11. Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions PMID: 11741991
    12. Glis2 functions as a negative modulator of beta-catenin/TCF-mediated transcription. PMID: 17289029
    13. identification of Gli-similar 2 (Glis2) as a novel binding protein for p120 catenin PMID: 17344476
    14. Study identified Glis2 as a transcription factor mutated in Nephronophthisis and demonstrate its essential role for the maintenance of renal tissue architecture through prevention of apoptosis and fibrosis. PMID: 17618285

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  • 相關疾病：
    Nephronophthisis 7 (NPHP7)
  • 亞細胞定位：
    Nucleus speckle. Cytoplasm.
  • 蛋白家族：
    GLI C2H2-type zinc-finger protein family
  • 組織特異性：
    Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon.
  • 數據庫鏈接：

    HGNC: 29450

    OMIM: 608539

    KEGG: hsa:84662

    STRING: 9606.ENSP00000262366

    UniGene: Hs.592087



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